The Porcine Pulmonary Surfactant Protein A (pSP-A) Immunogenicity Evaluation in the Murine Model

Dias, Sandra de Cássia; Santos, Fernanda L.; Sakauchi, Dirce; Iourtov, Dmitri; Raw, Isaı́as; Kubrusly, Flávia Saldanha

doi:10.4236/pp.2010.11004

2010

DOI: 10.4236/pp.2010.11004

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The Porcine Pulmonary Surfactant Protein A (pSP-A) Immunogenicity Evaluation in the Murine Model

Sandra de Cássia Dias¹,

Fernanda L. Santos²,

Dirce Sakauchi³

et al.

Abstract: This paper investigated the porcine surfactant protein A (pSP-A

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2014

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Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome

Nacif

Andraus²,

Kubrusly³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome. METHODS:A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software ® . Differences were considered statistically significant when p<0.05. RESULTS:Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05). CONCLUSION:Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response.

show abstract

Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome

Nacif

Andraus²,

Kubrusly³

et al. 2014

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

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The Porcine Pulmonary Surfactant Protein A (pSP-A) Immunogenicity Evaluation in the Murine Model

Abstract: This paper investigated the porcine surfactant protein A (pSP-A

Cited by 1 publication

References 11 publications

Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome

Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome

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