The pore size of PLGA bone implants determines the de novo formation of bone tissue in tibial head defects in rats

Abstract

Our analysis showed that the structure and dynamics of the regenerated extracellular matrix was very similar to that of the native bone, suggesting that biomineralization was significantly enhanced by the choice of the most appropriate implant material.

Water scaffolding in collagen: Implications on protein dynamics as revealed by solid‐state NMR

“…In line with previous reports, [11][12][13][14][17][18][19][20]59-62 our solid-state NMR studies of collagen samples of various origin confirm that the amplitude of collagen backbone and sidechain motions increases significantly on increasing the water content. This conclusion is supported by the changes observed in three different in nature NMR observables: (i) the linewidth dependence on the 1 H decoupling frequency; (ii) 13 C CSA changes for the peptide carbonyl groups, and (iii) 1 H- 13 C dipolar dephasing rates.…”

“…Despite the simplicity of the model considered, these results suggest that the increase of the water content could lead to significant increase of the internal restricted rotations (i.e., librations) about C-C a or N-C a bonds of the collagen backbone. Overall, the observed dependence of collagen dynamics on the water content is in agreement with the previous reports, [11][12][13][17][18][19][20][59][60][61][62] as well as the results of studies on the effect of hydration of the molecular mobility of collagen in bone and cartilage. [18][19][20][59][60][61][62] The dependence of collagen dynamics on the water surrounding appears to be its intrinsic property, which is retained in different environments in the presence of lipids, calcium phosphate, glycosaminoglycans, and other species.…”

“…backbone dynamics collagen from bovine Achilles tendon (CBAT) and in parchments are significantly restricted compared to collagens studied previously, but similar to the mineralized collagen 13,[17][18][19][20] ; ii. addition of water (either H 2 O or D 2 O) to parchments leads to a significant increase of backbone motional amplitudes of collagen molecules.…”

“…[17][18][19][20] Studies of FIGURE 1 An example of the collagen structural analog (PDB entry 1BKV), 9 showing water surrounding of a triple helix in the solid state. Red dots indicate oxygen atoms of water molecules.…”

Morphological and mechanical characterization of chitosan-calcium phosphate composites for potential application as bone-graft substitutes

“…In this regard, the use of biodegradable polymers, such as CS, associated to more-soluble forms of CP as bone substitutes allows the composite to initially support the mechanical stress and be re-absorbed over the time, opening space for new bone deposition (Penk et al, 2013). On the other hand, extremely high porosity and fast degradation may result in the loss of the surface that is needed for facilitation of bone formation (Bongio et al, 2010;Penk et al, 2013).…”