The Portrait of an Adult Liver Transplant Recipient in the United States From 1987 to 2013

Stepanova, Maria; Wai, Homan; Saab, Sammy; Mishra, Alita; Venkatesan, Chapy; Younossi, Zobair M.

doi:10.1001/jamainternmed.2014.2903

Cited by 39 publications

(46 citation statements)

References 7 publications

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“…Approximately 20 to 30% of primary LTs are performed for patients with ALD (Erim et al, 2007; Adam et al, 2012; Stepanova et al, 2014). Alcohol use disorders are the second common indication for LTs in the US and Europe (Burra et al, 2010; Rice et al, 2013; Singal et al, 2013).…”

Section: The Link Between Depression and Cldmentioning

confidence: 99%

Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?

Huang

Liu

2017

Front. Mol. Neurosci.

102

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The occurrence of depression is higher in patients with chronic liver disease (CLD) than that in the general population. The mechanism described in previous studies mainly focused on inflammation and stress, which not only exists in CLD, but also emerges in common chronic diseases, leaving the specific mechanism unknown. This review was to summarize the prevalence and risk factors of depression in CLD including chronic hepatitis B, chronic hepatitis, alcoholic liver disease, and non-alcoholic fatty liver disease, and to point out the possible underlying mechanism of this potential link. Clarifying the origins of this common comorbidity (depression and CLD) may provide more information to understand both diseases.

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Section: The Link Between Depression and Cldmentioning

confidence: 99%

Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?

Huang

Liu

2017

Front. Mol. Neurosci.

102

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“…[7] Subsequently, the MELD score was thoroughly validated in patients with a broad spectrum of liver diseases showing an excellent discriminatory power for prediction of short-term mortality. [4,6,8] Interestingly, the etiology of liver disease was not found to be a relevant predictor of mortality. [9] …”

Section: Introductionmentioning

confidence: 99%

MELD score as a predictor of mortality, length of hospital stay, and disease burden

Roth

Chrobak

Schädelin³

et al. 2017

Medicine

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“…Chronic hepatitis C infection is currently the most common indication for liver transplantation in the U.S. [1]. After the disease progresses to its most advanced stages which include hepatocellular carcinoma and liver failure, the only alternative to liver-related death is receiving a liver transplant.…”

Section: Introductionmentioning

confidence: 99%

Long-term outcomes of liver transplantation in patients with hepatitis C infection are not affected by HCV positivity of a donor

et al. 2016

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BackgroundThe use of HCV-positive livers for HCV-positive recipients is becoming more common. Our aim is to evaluate long-term outcomes in liver transplant recipients transplanted with HCV antibody-positive organs.MethodsFrom the Scientific Registry of Transplant Recipients (1995–2013), we selected all adult liver transplant recipients with HCV, and cross-sectionally compared long-term graft loss and mortality rates between those who were transplanted from HCV antibody-positive (HCV+) vs. HCV antibody-negative donors.ResultsWe included 33,668 HCV+ liver transplant recipients (54.0 ± 7.7 years old, 74.1% male, 71.0% white, 23.6% with liver malignancy). Of those, 5.7% (N = 1930) were transplanted from HCV+ donors; the proportion gradually increased from 2.9% in 1995 to 9.4% in 2013. Patients who were transplanted from HCV+ positive donors were more likely to be discharged alive after transplantation (95.4% vs. 93.9%, p = 0.006), but this difference was completely accounted for by a greater proportion of HCV+ donors in more recent study years (p = 0.10 after adjustment for the transplant year). After transplantation, both mortality in HCV patients transplanted from HCV+ donors (12.5% in 1 year, 24.2% in 3 years, 33.0% in 5 years) and the graft loss rate (2.2% in 1 year, 4.8% in 3 years, 7.5% in 5 years) were similar to those in HCV patients transplanted from HCV-negative donors (all p > 0.05).ConclusionsOver the past two decades, the use of HCV+ organs for liver transplantation has tripled. Despite this, the long-term outcomes of HCV+ liver transplant recipients transplanted from HCV+ donors were not different from those who were transplanted with HCV-negative organs.Electronic supplementary materialThe online version of this article (doi:10.1186/s12876-016-0551-z) contains supplementary material, which is available to authorized users.

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The Portrait of an Adult Liver Transplant Recipient in the United States From 1987 to 2013

Cited by 39 publications

References 7 publications

Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?

Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?

MELD score as a predictor of mortality, length of hospital stay, and disease burden

Long-term outcomes of liver transplantation in patients with hepatitis C infection are not affected by HCV positivity of a donor

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