The portrait of neem leaves-based high performance wound healing activity on zebrafish

Athiroh, Nour; Hayati, Ari; Pudjiwati, Istirochah; Taufiq, Achmad; Mubarakati, Nurul Jadid

doi:10.23869/bphjbr.27.1.20214

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Both types of saponins are soluble in water and ethanol. Flavonoids are compounds that are soluble in water and can be extracted with 70% ethanol and hydrolyzed tannins dissolve in water (especially hot water) to form colloids [69,70,71]. Meanwhile, gotu kola has water-soluble compounds, namely flavonoids and polyphenols [72].…”

Section: Total Water Soluble Ingredientsmentioning

confidence: 99%

Physicochemical Properties of Herbal Tea Bags from Belimbing Wuluh Leaves (Averrhoa bilimbi) and Gotu Kola Leaves (Centella asiatica) with the Addition of Cinnamon Powder (Cinnamomun burmanii)

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Rozi

et al. 2022

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This study aims to study the characteristics of herbal teabags from belimbing wuluh leaves and gotu kola leaves with the addition of cinnamon powder. This study used a completely randomized design with 5 treatments, namely differences in the addition of cinnamon powder 0%, 1%, 2%, 3% and 4% with 3 replications. The data obtained were analyzed statistically using ANOVA (Analysis Of Variance) and if they were significantly different, then continued with the DNMRT (Duncan's News Multiple Range Test) test at 5% level. The results showed that the level of addition of cinnamon powder had a significant effect on antioxidant activity, total water soluble ingredients, total polyphenols, color, taste, and flavor. Differences in the substitution level of cinnamon powder had no significant effect on water content and pH. The best treatment in this study was treatment E with the addition of 4% cinnamon powder, the organoleptic results obtained were the average value of color preference 3.95 (like), taste 3.65 (like), and flavor 4 (like). The results of chemical analysis on tea products are water content 7.88%, total polyphenols 109.32 mg GAE/g, IC50 value 96.71, total water soluble ingredients 19.66% and in steeped tea pH value is 6.13, and activity antioxidant 36.93%.

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Section: Total Water Soluble Ingredientsmentioning

confidence: 99%

Physicochemical Properties of Herbal Tea Bags from Belimbing Wuluh Leaves (Averrhoa bilimbi) and Gotu Kola Leaves (Centella asiatica) with the Addition of Cinnamon Powder (Cinnamomun burmanii)

Sylvi

Syukri

Rozi

et al. 2022

EKSAKTA

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“…The effect of neem leaves on wound closure of an injured Zebrafish was studied by Athiroh et al 32 .…”

Section: Percentage Wound Contraction Over Timementioning

confidence: 99%

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2022

IJPSR

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Cutaneous wound healing starts with an acute inflammatory phase marked by secretion of pro-inflammatory mediators that enhance infiltration of leukocytes with a peak in the first 24 to 48 h. This resolves to enable the continuation of other phases in series, namely, the proliferative, re-epithelialization, vascularisation, and tissue remodelling phases. The study uses a mechanical device, for the first time, to create a mechanical cutaneous wound in adult Zebrafish to simulate mammalian cutaneous wound. Topical application of 0.5% ointment of a fraction from hexane leaf extract of Vernonia arborea, accelerated wound healing in the developed model. The phytocompound in the fraction modulates the inflammation kinetics, increasing initial inflammation at 24 hrs by expediting neutrophil infiltration, three folds more than the untreated model. The resolution of inflammation was rapid in the experimental group after 3 dpw compared to the untreated control resulting in speedy proliferation and migration of keratinocytes and three times faster wound closure, measuring up to 92.3% as compared to 95.3% in the positive control group. The fraction also exhibited an anti-oxidant role and prevented the oxidative damage of wound tissue, with 30-40% higher granulation tissue weight than the povidone-iodine standard treatment. The extracellular matrix formation was found to be enhanced, marked by a two-fold increase in the expression of tissue markers like hexuronic acid, hydroxyproline, and hexosamine. The results were analogous to the wound healing process in mammals, making the phytocompound a potent topical wound-healing agent that may be tested in preclinical and clinical trials.INTRODUCTION: Among the wounds that result in lack of structural and functional communication between the cells forming the tissue, those that result in significant blood loss and those that do not heal with time need a clinical intervention 1 . The delay in healing is influenced by a lot of factors like depth of the wound, diabetic condition, microbial colonization of the wound, immunecompromised conditions, malnutrition, and others 2 .

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The portrait of neem leaves-based high performance wound healing activity on zebrafish

Cited by 2 publications

References 8 publications

Physicochemical Properties of Herbal Tea Bags from Belimbing Wuluh Leaves (Averrhoa bilimbi) and Gotu Kola Leaves (Centella asiatica) with the Addition of Cinnamon Powder (Cinnamomun burmanii)

Physicochemical Properties of Herbal Tea Bags from Belimbing Wuluh Leaves (Averrhoa bilimbi) and Gotu Kola Leaves (Centella asiatica) with the Addition of Cinnamon Powder (Cinnamomun burmanii)

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