The POSEIDON Trial: Will Secondary End Points Change Our Clinical Practice?

Remón, Jordi; Hendriks, Lizza; Reck, Martin

doi:10.1200/jco.22.01737

JCO

2023

DOI: 10.1200/jco.22.01737

|View full text |Cite

The POSEIDON Trial: Will Secondary End Points Change Our Clinical Practice?

Jordi Remón

Lizza Hendriks

Martin Reck

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Phase III Evaluation of Treatment Combinations in Three-Arm Trials

Korn,

Allegra,

Freidlin

2024

JCO

View full text Add to dashboard Cite

Phase III trials that randomly assign patients to a control treatment (C), an experimental treatment (A), or a combination treatment (AB) should be designed with the goal to recommend the best treatment: AB (if it is better than A and C), A (if it is better than C, and AB is not better than A), or C (if neither AB nor A is better than C). However, this goal can be challenging to achieve with statistical confidence. We performed a survey of cancer trials published in five journals from January 2018 to May 2024 to assess the trial designs being used in this setting and found that three quarters of them did not have a provision for a formal comparison of the AB treatment arm with the A treatment arm, a possible shortcoming. A limited simulation evaluates two analysis strategies that incorporate an AB versus A comparison and is used to formulate some recommendations for designing these types of trials.

show abstract

Phase III Evaluation of Treatment Combinations in Three-Arm Trials

Korn,

Allegra,

Freidlin

2024

JCO

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The POSEIDON Trial: Will Secondary End Points Change Our Clinical Practice?

Cited by 1 publication

References 24 publications

Phase III Evaluation of Treatment Combinations in Three-Arm Trials

Phase III Evaluation of Treatment Combinations in Three-Arm Trials

Contact Info

Product

Resources

About