The positive effects of dietary inositol on juvenile hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu) fed high-lipid diets: Growthperformance, antioxidant capacity and immunity

Pan, Simiao; Yan, Xiaobo; Dong, Xiaohui; Li, Tao; Suo, Xiangxiang; Tan, Beiping; Zhang, Shuang; Li, Zhihao; Yang, Yefeng; Zhang, Haitao

doi:10.1016/j.fsi.2022.05.016

Cited by 22 publications

(10 citation statements)

References 112 publications

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“…Our results also revealed that MI supplementation resulted in not only a significant increase in serum antioxidants, GPX, and SOD but also a significant reduction in NO biomarkers (Table 6 ) . Our findings are consistent with other studies (Jamilian et al., 2018 ; Lee et al., 2019 ; Pan et al., 2022 ) reporting the effectiveness of inositol supplementation on antioxidant indices. Inositol derivatives appear to play a protective role against OS caused by cell metabolism (Bizzarri et al., 2016 ).…”

Section: Discussionsupporting

confidence: 94%

“…Inositol derivatives appear to play a protective role against OS caused by cell metabolism (Bizzarri et al, 2016). Pan et al (Pan et al, 2022) showed that dietary inositol can significantly increase the activities of SOD, CAT, GPX, and TAC contents and reduce the content MI supplementation improved liver enzymes, which is consistent with the results of the studies conducted by Zhao et al (Zhao et al, 2018), Lee et al (Lee et al, 2019), and also Pan et al (Pan et al, 2022). Moreover, we found that MI supplementation for 8 weeks could reduce at least one degree of liver steatosis severity in patients with NAFLD, which is in line with the results of an animal study conducted by Zhao et al after DCI supplementation (150 mg/kg for 2 weeks) in rats (Zhao et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Pan et al. (Pan et al., 2022 ) showed that dietary inositol can significantly increase the activities of SOD, CAT, GPX, and TAC contents and reduce the content of MDA as well as ROS. MI supplementation also increases the activity of glucose in the pentose phosphate pathway through more production of NADPH, increasing the ratio of NADPH to NADP + and the activity of the antioxidant system, and maintaining cell health.…”

Section: Discussionmentioning

confidence: 99%

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Does myo‐inositol supplementation influence oxidative stress biomarkers in patients with non‐alcoholic fatty liver disease?

Rostami,

Arefhosseini,

Tutunchi

et al. 2023

Food Science & Nutrition

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Myo‐inositol (MI) is a carbocyclic sugar polyalcohol. MI has known to exert anti‐inflammatory, anti‐oxidant, and anti‐diabetic activities. This study aimed to investigate the effects of MI supplementation on oxidative stress biomarkers in obese patients with non‐alcoholic fatty liver disease (NAFLD). In this double‐blinded placebo‐controlled randomized clinical trial, 51 newly diagnosed obese patients with NAFLD were randomly assigned to receive either MI (4 g/day) or placebo supplements accompanied by dietary recommendations for 8 weeks. Oxidative stress biomarkers, nutritional status, as well as liver enzymes and obesity indices were assessed pre‐ and post‐intervention. A total of 48 patients completed the trial. Although anthropometric measures and obesity indices decreased significantly in both groups, the between‐group differences adjusted for confounders were non‐significant for these parameters, except for weight (p = .049); greater decrease was observed in the MI group. Iron and zinc intakes decreased significantly in both groups; however, between‐group differences were non‐significant at the end of the study. No significant between‐group differences were revealed for other antioxidant micronutrients at the study endpoint. Sense of hunger, feeling to eat, desire to eat sweet and fatty foods reduced significantly in both groups (p < .05), while the feeling of satiety increased significantly in the placebo group (p = .002). No significant between‐group differences were observed for these parameters, except for desire to eat fatty foods; a greater decrease was observed in the MI group (p = .034). Serum levels of glutathione peroxidase (GPx) and superoxide dismutase (SOD) significantly increased in both study groups (p < .05); however, the between‐group differences were non‐significant at the end of the study. Furthermore, the between‐group differences were non‐significant for other oxidative stress biomarkers, except for serum nitric oxide (NO) level; a greater decrease was observed in the MI group. MI supplementation could significantly improve weight, desire to eat fatty foods, serum levels of NO, as well as the aspartate aminotransferase (AST)/ALT ratio.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Does myo‐inositol supplementation influence oxidative stress biomarkers in patients with non‐alcoholic fatty liver disease?

Rostami,

Arefhosseini,

Tutunchi

et al. 2023

Food Science & Nutrition

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“…Although the appropriate dietary lipid level for hybrid groupers was 10% [ 17 , 23 , 24 ], a higher lipid level in the diet was used in the practical feed in order to realize the protein-saving effect. However, excessive dietary lipids would cause lipid accumulation, inflammation and decreased PER and PDR in hybrid groupers, hybrid yellow catfish ( Pelteobagrus fulvidraco × P. vachelli ) and yellow croakers ( Larimichthys crocea ), inhibiting fish growth [ 25 , 26 , 27 ]. In this experiment, when 0.1% steroidal saponins was added to the diet with 14% crude lipids, more PER and PDR were obtained, but when steroidal saponins was up to 0.2%, fish growth was significantly inhibited.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Steroid Saponins on Growth Performance, Serum and Liver Glucose, Lipid Metabolism and Immune Molecules of Hybrid Groupers (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatu) Fed High-Lipid Diets

et al. 2023

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High-lipid diets are attributed to excessive lipid deposition and metabolic disturbances in fish. The aim of this experiment was to investigate the effects of steroidal saponins on growth performance, immune molecules and metabolism of glucose and lipids in hybrid groupers (initial weight 22.71 ± 0.12 g) fed high-lipid diets. steroidal saponins (0%, 0.1% and 0.2%) were added to the basal diet (crude lipid, 14%) to produce three experimental diets, designated S0, S0.1 and S0.2, respectively. After an 8-week feeding trial, no significant differences were found between the S0 and S0.1 groups in percent weight gain, specific growth rate, feed conversion ratio, protein efficiency ratio and protein deposition rate (p > 0.05). All those in the S0.2 group were significantly decreased (p < 0.05). Compared to the S0 group, fish in the S0.1 group had lower contents of serum triglyceride and low-density lipoprotein cholesterol and higher high-density lipoprotein cholesterol and glucose (p < 0.05). The activities of superoxide dismutase, catalase and glutathione peroxidase were significantly higher, and malondialdehyde contents were significantly lower in the S0.1 group than in the S0 group (p < 0.05). Hepatic triglyceride, total cholesterol and glycogen were significantly lower in the S0.1 group than in the S0 group (p < 0.05). Activities of lipoprotein lipase, total lipase, glucokinase and pyruvate kinase, and gene expression of lipoprotein lipase, triglyceride lipase and glucokinase, were significantly higher in the S0.1 group than in the S0 group. Interleukin-10 mRNA expression in the S0.1 group was significantly higher than that in the S0 group, while the expression of interleukin-6 and tumor necrosis factor-α genes were significantly lower than those in the S0 group. In summary, adding 0.1% steroidal saponins to a high-lipid diet not only promoted lipolysis in fish livers, but also activated glycolysis pathways, thus enhancing the utilization of the dietary energy of the groupers, as well as supporting the fish’s nonspecial immune-defense mechanism.

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“…Oxidative damage is an unavoidable part of the physiological activity of aerobic organisms, due to the continuous production of oxygen radicals during their physiological metabolism [ 44 ]. The scavenging of oxygen radicals is accomplished by the antioxidant system, including antioxidant enzymes and antioxidant active substances [ 45 ]. Therefore, the antioxidant capacity is commonly used to evaluate the health status of fish.…”

Section: Discussionmentioning

confidence: 99%

High Dietary Histamine Induces Digestive Tract Oxidative Damage in Juvenile Striped Catfish (Pangasianodon hypophthalmus)

Liu

Huang

et al. 2022

Antioxidants

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A 56-day feeding trial investigated the effects of dietary histamine on the antioxidant capacity, gastric and intestinal barrier functions, and growth performance of striped catfish (Pangasianodon hypophthalmus). Seven isonitrogenous (34.0% crude protein) and isolipidic (10.5% crude lipid) diets were formulated with supplemental 0, 15, 30, 60, 120, 240, and 480 mg/kg of histamine, named H0, H15, H30, H60, H120, H240, and H480 group, respectively. Results showed that the weight gain rate, specific growth rate, relative intestinal length in the H240 and H480 groups, and the condition factors in the H480 group were significantly lower than those in the H0 group. Intestinal total antioxidant capacity, peroxidase, catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase activities in the H480 group were significantly lower than those in the H0 group, whereas intestinal malondialdehyde content exhibited the opposite trend. Intestinal complement 3, complement 4, immunoglobulin M, and Recombinant Mucin 2 in the H480 group were significantly lower than those in the H0 group, in contrast to intestinal lipopolysaccharide content. Intestinal IL-10 gene expression in the H480 group was significantly lower than that in the H0 group, whereas the TNF-α, IL-1, IL-6, and IL-8 gene expression exhibited opposite results. Scanning and transmission electron microscopic observation of the gastrointestinal tract revealed severe damage to the gastric mucosa and intestinal epithelium in the H480 group. The abundance of Treponema in the histamine groups was significantly higher than that in the H0 group. These results indicated that high dietary histamine decreases intestinal immunity and antioxidant capacity, inducing digestive tract oxidative damage and ultimately decreasing the growth of striped catfish.

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The positive effects of dietary inositol on juvenile hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu) fed high-lipid diets: Growthperformance, antioxidant capacity and immunity

Cited by 22 publications

References 112 publications

Does myo‐inositol supplementation influence oxidative stress biomarkers in patients with non‐alcoholic fatty liver disease?

Does myo‐inositol supplementation influence oxidative stress biomarkers in patients with non‐alcoholic fatty liver disease?

Effects of Dietary Steroid Saponins on Growth Performance, Serum and Liver Glucose, Lipid Metabolism and Immune Molecules of Hybrid Groupers (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatu) Fed High-Lipid Diets

High Dietary Histamine Induces Digestive Tract Oxidative Damage in Juvenile Striped Catfish (Pangasianodon hypophthalmus)

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