The positive effects of Mediterranean-neutropenic diet on nutritional status of acute myeloid leukemia patients under chemotherapy

The Effects of a Mediterranean Diet Intervention on Cancer-Related Fatigue for Patients Undergoing Chemotherapy: A Pilot Randomized Controlled Trial

“…Our data add to the growing body of literature that a MedDiet intervention is safe and feasible during active cancer treatment. Mediterranean-inspired diets have been conducted with success in other randomized controlled trials among patients undergoing chemotherapy including patients with lung cancer (inclusion criteria included patients on other active treatments as well) [ 45 ], breast cancer [ 46 ], and acute myeloid leukemia [ 47 ]. Gioxari et al [ 45 ] administered a resource-intensive 3-month intervention with personalized nutritional counseling, daily diet plans, and educational booklets, delivered by experienced dietitians.…”

“…They measured compliance using six 24-hour recalls and reported differences between the intervention and control groups for whole grains and legumes (higher in the intervention group, n = 47), as well as white bread and refined grains, sugar, dairy, and processed meat (higher in the control group, n = 47) [ 46 ]. Jalali et al [ 47 ] administered a 4-week personalized intervention under the direction of a nutritionist ( n = 25 in the MedDiet group and n = 25 in the control group), however, they did not report adherence [ 47 ]. None of these studies reported fatigue.…”

The Effects of a Mediterranean Diet Intervention on Cancer-Related Fatigue for Patients undergoing Chemotherapy: A Pilot Randomized Controlled Trial

“…Our data add to the growing body of literature that a MedDiet intervention is safe and feasible during active cancer treatment. Mediterranean-inspired diets have been conducted with success in other randomized controlled trials among patients undergoing chemotherapy including patients with lung cancer (inclusion criteria included patients on other active treatments as well) [44], breast cancer [45], and acute myeloid leukemia [46]. Gioxari et al [44] administered a resource-intensive 3-month intervention with personalized nutritional counseling, daily diet plans, and educational booklets, delivered by experienced dietitians.…”

“…They measured compliance using six 24-hour recalls and reported differences between the intervention and control groups for whole grains and legumes (higher in the intervention group, n=47), as well as white bread and refined grains, sugar, dairy, and processed meat (higher in the control group, n=47) [45]. Jalali et al [46] administered a 4-week personalized intervention under the direction of a nutritionist (n=25 in the MedDiet group and n=25 in the control group), however they did not report adherence [46]. Our intervention was also intensive, with weekly food provision, weekly phone calls, educational handouts, and a custom cookbook.…”

“…While our frozen meal supplier was local and had a limited shipping radius, larger studies could utilize nationwide food delivery and shipping services. It was not tailored to the individual for calorie or macronutrient intake as in other studies (e.g., [45,46]), thereby reducing resources of a registered dietitian. This study employed patient-reported outcomes and objective metabolic measures at the same time points, allowing us to directly probe underlying metabolic mechanisms of fatigue and how diet affected these measures.…”