2021
DOI: 10.3390/ijerph18105365
|View full text |Cite
|
Sign up to set email alerts
|

The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

Abstract: Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2021
2021
2021
2021

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(2 citation statements)
references
References 46 publications
(96 reference statements)
0
2
0
Order By: Relevance
“…Constable et al [1] examined whether the relationship between moderate-to-vigorous physical activity and total body less head bone mineral content (TBLH-BMC) is mediated by the free leptin index in prepubertal children. In this cross-sectional study, the authors used a four-way decomposition mediation analysis method, which showed that moderate-to-vigorous physical activity had a positive controlled direct effect on TBLH-BMC, independent of free leptin and possibly through mechanical loading, in both girls and boys [1]. However, since their participants were predominantly of normal weight, these observations may not apply to overweight and obese children at different stages of puberty [1].…”
Section: Physical Activity and Skeletal Developmentmentioning
confidence: 99%
See 1 more Smart Citation
“…Constable et al [1] examined whether the relationship between moderate-to-vigorous physical activity and total body less head bone mineral content (TBLH-BMC) is mediated by the free leptin index in prepubertal children. In this cross-sectional study, the authors used a four-way decomposition mediation analysis method, which showed that moderate-to-vigorous physical activity had a positive controlled direct effect on TBLH-BMC, independent of free leptin and possibly through mechanical loading, in both girls and boys [1]. However, since their participants were predominantly of normal weight, these observations may not apply to overweight and obese children at different stages of puberty [1].…”
Section: Physical Activity and Skeletal Developmentmentioning
confidence: 99%
“…In this cross-sectional study, the authors used a four-way decomposition mediation analysis method, which showed that moderate-to-vigorous physical activity had a positive controlled direct effect on TBLH-BMC, independent of free leptin and possibly through mechanical loading, in both girls and boys [1]. However, since their participants were predominantly of normal weight, these observations may not apply to overweight and obese children at different stages of puberty [1]. In the same spirit, the longitudinal study by Ludwa et al [2] followed a diverse sample of 180 children, aged 8-16 years, for 3 years, and showed that physical activity and BMI had a significant direct impact on bone properties and an additional indirect effect on muscle strength, which was the strongest predictor of bone speed with sound measurements.…”
Section: Physical Activity and Skeletal Developmentmentioning
confidence: 99%