The positivity of estrogen receptor and progesterone receptor may not be associated with metastasis and recurrence in epithelial ovarian cancer

Chen, Shouzhen; Dai, Xujing; Gao, Yifei; Shen, Fang; Ding, Jianxun; Chen, Qi

doi:10.1038/s41598-017-17265-6

Cited by 37 publications

(24 citation statements)

References 37 publications

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“…In their study of sex steroid hormone receptors expressed in ovarian carcinomas, Gomora MJ 12 . However, other studies confirmed ER positivity in these tumors, associated with recurrent disease and peritoneal metastasis 13 . Also, other studies stated that LG tumors have higher ER and PR expression compared to HG tumors and that estrogen receptor expression was associated with increased risk of lympho-vascular space invasion 14,15 .…”

Section: Resultsmentioning

confidence: 82%

High-grade versus low-grade serous carcinoma of the ovary – current differential diagnosis and perspectives

Popa¹,

COROBEA²,

Munteanu³

et al. 2018

Arch Balk Med Union

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Comparaison entre les deux types de carcinome séreux de l'ovaire, à haut et à bas degré-diagnostic différentiel courant et perspectives Introduction. Le carcinome séreux est responsable de 47% de tous les cancers de l'ovaire. Parmi ces cas, 5% seulement sont représentés par un carcinome séreux à bas degré, le reste d'entre eux représentant un carcinome séreux à haut degré. Objectifs. Le but de cette étude est une approche observationnelle des différences et des similitudes entre les deux types de carcinome séreux de l'ovaire, qui doivent être considérés comme des formes différentes de cancer et traités avec précaution. Méthodes. Nous avons réalisé une étude rétrospective utilisant trois cas de carcinome séreux ovarien à haut degré et trois cas de carcinome séreux à bas degré ovarien, diagnostiqués à l'Hôpital Universitaire d'Urgence de Bucarest. Nous avons analysé l'âge des patients, les symptômes cliniques, les caractéristiques ABSTRACT Introduction. Serous carcinoma is responsible for 47% of all ovarian cancers, and from these cases, only 5% are represented by low-grade serous carcinoma, the rest of them accounting for high-grade serous carcinoma. Objective. The aim of this study is an observational approach of the differences and similarities of the two types of serous carcinoma of the ovary, that must be seen as different forms of cancer and rendered with care. Methods. We performed a retrospective study using three cases of ovarian high-grade serous carcinoma and three cases of ovarian low-grade serous carcinoma, diagnosed at the University Emergency Hospital Bucharest. We analyzed patients' age, clinical symptoms, macroscopic and microscopic features together with immunohistochemistry tests. Results. Mean age for HG carcinoma was 71.3 years old and for LG carcinoma 47.6 years old. Average tumor diameter was with 5.67 cm higher for LG carcinoma. The most encountered stage for HG tumors was pT2a and for LG tumors was pT1a. Mean value

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Section: Resultsmentioning

confidence: 82%

High-grade versus low-grade serous carcinoma of the ovary – current differential diagnosis and perspectives

Popa¹,

COROBEA²,

Munteanu³

et al. 2018

Arch Balk Med Union

View full text Add to dashboard Cite

show abstract

“…The difference in the incidence of endometrial and ovarian cancers may result in differences in clinical characteristics and pathological parameters by ethnicities. Our previous studies reported that endometrial and ovarian cancers occur more frequently in Chinese women before menopause [22][23][24], whilst 75% of endometrial and ovarian cancers occur after menopause in Caucasians [25]. Our recent unpublished data also showed differences in clinical characteristics and pathological parameters in breast cancer between Chinese and New Zealand Europeans.…”

Section: Ivyspringmentioning

confidence: 68%

Association of benign gynaecological diseases and risk of endometrial and ovarian cancers

Shen¹,

Liu

Lin

et al. 2020

J. Cancer

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Objective: Gynaecologic benign diseases such uterine fibroids share similar pathogeneses with endometrial and ovarian cancers. Whether a history of uterine fibroids increases the risk of developing endometrial or ovarian cancers is controversial, due to uterine fibroids was self-reported in those studies. Methods: In our current case-control study, 268 women with endometrial cancer and 108 women with ovarian cancer were included. In addition, 500 women without gynaecological cancers were randomly selected as a control group. Uterine fibroids in both groups were clinically diagnosed by pelvic examination and ultrasound. Data on age, parity, gravida, stages of cancers and history of uterine fibroids, endometriosis and adenomyosis were collected from hospital database. Results: After adjusted age and parity, the odds of women with history of uterine fibroids or endometriosis were lower in women with endometrial cancer than controls (odds ratio: 0.148, 95% CI: 0.097, 0.225, or 0.360, 95% CI: 0094, 1.381, respectively). The odds of women with a history of uterine fibroids or endometriosis were lower in women with ovarian cancer than controls (odds ratio: 0.141, 95% CI: 0.085, 0.235, or 1.057, 95% CI: 0.377, 2.963, respectively). However, the odds of women with a history of adenomyosis were higher in women with endometrial or ovarian cancers than controls (odd ratio: 3.757, 95% CI: 1.858, 7.599 or 2.341, 95% CI: 1.086, 5.045, respectively). Conclusion: Our observational data suggested that uterine fibroids or endometriosis may be not associated with the increased risk of developing endometrial or ovarian cancer. However, a history of adenomyosis may do.

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“…GPR30 expression is higher in EAOC than in benign OE (96). The upregulation of ESR expression is associated with a better clinical outcome in ovarian cancer (95) and CCC (14), suggesting the role of ESR in tumor initiation or the early development of primary EC, but not in EC progression.…”

Section: Similar Epigenetic Modifications: Gene-environment Interactimentioning

confidence: 96%

“…There are two types of estrogen receptors (ESRs), ESR1 (also known as ERα) and ESR2 (ERβ). The ESR expression level has been shown to be higher in EC and high-grade serous than in CCC and mucinous carcinoma (95). Among EAOC, ESR positivity has been shown to be significantly higher in EC (91%), but lower in CCC (8%) (60).…”

Section: Similar Epigenetic Modifications: Gene-environment Interactimentioning

confidence: 99%

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Integrating modern approaches to pathogenetic concepts of malignant transformation of endometriosis

et al. 2018

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In the present study, we summarize the role of the shared and independent (epi)genetic background between endometrioid carcinoma (EC) and clear cell carcinoma (CCC), two histological subtypes of endometriosis-associated ovarian cancer (EAOC). Using the PubMed database, we conducted a literature review of various studies related to the malignant transformation of endometriosis. Both endometriosis and EAOC face potential environmental hazards, including hemoglobin (Hb), heme and free iron, which induces DNA damage and mutations. Although EC is distinguished from CCC due to different morphologies, both represent common environmental profiles and maintain the similar (epi)genomic abnormalities with multiple overlaps and share similar molecular signatures. By contrast, EAOC also has diseasespecific gene signatures corresponding with each histological subtype: Estrogen receptor promotes EC cell proliferation ('go') and hepatocyte nuclear factor-1β (HNF-1β) induces CCC cell cycle arrest ('stop') under oxidative stress conditions. This model underscores a subtype-dependent 'go or stop' dichotomy, possibly through better ability to adapt in a changing environment. It was found that cyst fluid Hb and iron concentrations were significantly lower in EAOC when compared to benign ovarian endometrioma (OE), supporting the hypothesis that the redox imbalance plays a key role in the pathogenesis of EAOC. There are at least two phases of iron carcinogenesis and tumor progression: The initial wave of iron-induced oxidative stress and DNA mutations would be followed by the second big wave of subsequent synthesis of the antioxidants, which diminishes cellular oxidative stress capacity, increases apoptosis resistance and promotes tumor initiation and progression. Special emphasis is given to novel pathophysiological concepts of malignant transformation of endometriosis.

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The positivity of estrogen receptor and progesterone receptor may not be associated with metastasis and recurrence in epithelial ovarian cancer

Cited by 37 publications

References 37 publications

High-grade versus low-grade serous carcinoma of the ovary – current differential diagnosis and perspectives

High-grade versus low-grade serous carcinoma of the ovary – current differential diagnosis and perspectives

Association of benign gynaecological diseases and risk of endometrial and ovarian cancers

Integrating modern approaches to pathogenetic concepts of malignant transformation of endometriosis

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