The possibility of angiogenesis inhibition in cutaneous melanoma by bevacizumab-loaded lipid-chitosan nanoparticles

Abdi, Fereshteh; Arkan, Elham; Eidizadeh, Mojtaba; Valipour, Elahe; Naseriyeh, Tahereh; Gamizgy, Younes Hossainy; Mansouri, Kamran

doi:10.1007/s13346-022-01215-5

Cited by 6 publications

(2 citation statements)

References 48 publications

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“…Thus, the application of bevacizumab in nanomedicine has been highly researched to investigate how to alleviate the side effects. Abdi et al [ 94 ] reported the synthesis of lipid-coated chitosan nanoparticles for the local administration of bevacizumab (BEV). This resulted in enhanced antitumor activity by suppressing proliferation and ECs angiogenesis.…”

Section: Nanomedicines For Targeting Tme: Application Of Natural and ...mentioning

confidence: 99%

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Avgoustakis,

Angelopoulou

2024

Pharmaceutics

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Solid tumors are composed of a highly complex and heterogenic microenvironment, with increasing metabolic status. This environment plays a crucial role in the clinical therapeutic outcome of conventional treatments and innovative antitumor nanomedicines. Scientists have devoted great efforts to conquering the challenges of the tumor microenvironment (TME), in respect of effective drug accumulation and activity at the tumor site. The main focus is to overcome the obstacles of abnormal vasculature, dense stroma, extracellular matrix, hypoxia, and pH gradient acidosis. In this endeavor, nanomedicines that are targeting distinct features of TME have flourished; these aim to increase site specificity and achieve deep tumor penetration. Recently, research efforts have focused on the immune reprograming of TME in order to promote suppression of cancer stem cells and prevention of metastasis. Thereby, several nanomedicine therapeutics which have shown promise in preclinical studies have entered clinical trials or are already in clinical practice. Various novel strategies were employed in preclinical studies and clinical trials. Among them, nanomedicines based on biomaterials show great promise in improving the therapeutic efficacy, reducing side effects, and promoting synergistic activity for TME responsive targeting. In this review, we focused on the targeting mechanisms of nanomedicines in response to the microenvironment of solid tumors. We describe responsive nanomedicines which take advantage of biomaterials’ properties to exploit the features of TME or overcome the obstacles posed by TME. The development of such systems has significantly advanced the application of biomaterials in combinational therapies and in immunotherapies for improved anticancer effectiveness.

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Section: Nanomedicines For Targeting Tme: Application Of Natural and ...mentioning

confidence: 99%

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Avgoustakis,

Angelopoulou

2024

Pharmaceutics

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“…Processes such as angiogenesis and epithelial-mesenchymal transition (EMT) play a key role in tumor proliferation, migration, and invasion [6][7][8][9]. Numerous studies have reported that tumor cells can in uence the cytological behavior of vascular endothelial cells and epithelial cells to achieve proliferation, migration and invasion by altering the immune microenvironment [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Multiomics reveals the role of macrophage-vascular endothelial cell interactions in the hepatoblastoma tumor microenvironment

Zhu

Xie

Kang

et al. 2023

Preprint

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Background Hepatoblastoma is a common tumor in childhood, characterized by immature histology and diverse cell lineages. The purpose of this study is to identify the genes that are abnormally expressed in hepatoblastoma, and to explore and verify the targets of intercellular communication that affect the tumor immune microenvironment. Methods Through comprehensive analysis of gene expression from GSE133039 and GSE180664 data sets, the differentially expressed genes in cancer tissues and adjacent tissues were obtained. GO and KEGG enrichment analysis is used to predict the biological function and signal transduction pathway of differential expression gene enrichment. Use cytoscape to build PPI network to filter hubgene; Construct correlation analysis of immune cell infiltration to infer the correlation between immune cells. Combined with single-cell transcriptome data, further reveal the relationship between cells and signal targets of cell communication. Results 58 differentially expressed genes with high expression and 94 differentially expressed genes with low expression were obtained from the two data sets of hepatoblastoma. They were mainly involved in the signal transduction related to metastasis. PPI network screened 50 hubgenes. The correlation analysis of immune cell infiltration of different genes showed that macrophages were significantly correlated with endothelial cells. Combined with the analysis of single-cell transcriptome data, hepatoblastoma was divided into 11 cell subpopulations, and 16 genes in hubgene were expressed in different cell subpopulations, in which LFNG was highly expressed in macrophages and monocytes, which served as the target of intercellular communication to promote the development of hepatoblastoma. Conclusion In this study, we identified the genes that were abnormally expressed in hepatoblastoma, and affected the cellular communication of hepatoblastoma through LFNG target, thus affecting the progress of tumor. Therefore, LFNG may become a therapeutic target for hepatoblastoma.

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Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma treatment

Xu,

2023

Cancer Letters

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The possibility of angiogenesis inhibition in cutaneous melanoma by bevacizumab-loaded lipid-chitosan nanoparticles

Cited by 6 publications

References 48 publications

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Multiomics reveals the role of macrophage-vascular endothelial cell interactions in the hepatoblastoma tumor microenvironment

Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma treatment

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