The possibility of evidence-based psychiatry: depression as a case

Stojanov, Drozdstoy; Korf, Jakob; Jonge, Peter de; Popov, Georgi

doi:10.1007/s13148-010-0014-2

Cited by 36 publications

(23 citation statements)

References 49 publications

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“…All data acquired externally to the domain of clinical psychopathology are regarded as irrelevant to diagnosis. This refers to most recent and current studies in basic neuroscience, which are supposed to be involved in translation [e.g., genetics, immunology, electroencephalography (EEG), and functional neuroimaging (e.g., focus on functional magnetic resonance imaging, fMRI)] ( 6 ). In reality, triangulation is performed within one and the same realm of knowledge, and it is the realm of narrative, either professional (interviews) or patient’s (self-assessment), whereby both converge into the quantitative measures, named scales.…”

Section: Atypical Case: Depressionmentioning

confidence: 99%

Translational Functional Neuroimaging in the Explanation of Depression

Stoyanov¹,

Kandilarova²,

Borgwardt³

2017

Balkan Med J

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Translation as a notion and procedure is deeply embodied in medical science and education. Translation includes the possibility to translate data across disciplines to improve diagnosis and treatment procedures. The evidence accumulated using translation serves as a vehicle for reification of medical diagnoses. There are promising, established post hoc correlations between the different types of clinical tools (interviews and inventories) and neuroscience. The various measures represent statistical correlations that must now be integrated into diagnostic standards and procedures but this, as a whole, is a step forward towards a better understanding of the mechanisms underlying psychopathology in general and depression in particular. Here, we focus on functional magnetic resonance imaging studies using a trans-disciplinary approach and attempt to establish bridges between the different fields. We will selectively highlight research areas such as imaging genetics, imaging immunology and multimodal imaging, as related to the diagnosis and management of depression.

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Section: Atypical Case: Depressionmentioning

confidence: 99%

Translational Functional Neuroimaging in the Explanation of Depression

Stoyanov¹,

Kandilarova²,

Borgwardt³

2017

Balkan Med J

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“…Korf has illuminated that the signal detected via neuro-imaging techniques (like PET or fMRI) is actually the restorative iso-energetic response of the neural networks after performance of certain mental activity, i.e. it comes as an effect from, not as a cause for the psychic phenomena (17,18) .…”

Section: Ruling Out Epiphenomenalismmentioning

confidence: 99%

A linkage of mind and brain: towards translational validity between neurobiology and psychiatry

Stoyanov

2014

Biomedical Reviews

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Aim: There are prominent discrepancies in the general approaches of psychology and psychiatry, many of them due to diverse and incompatible tacit positions on the mind-brain debate (MBD). For this reason we need to enhance the dialogue with neurosciences and other human sciences relevant to the problems of psychopathology. To achieve such goal we can reduce the level of diversity of mind-brain problem project-solutions as implied in different theoretical models and practices. Arguments: I shall trace the MBD to the one of the most relevant for the modern psychopathology areas: the group of neurosciences. We seek the interference of the philosophical assumptions, the evidence of neuroscience and the development of psychopathology. We prove by a post rem analysis that the reduced group of predominant project-solutions of MBD excludes genuine forms of dualism and extreme forms of physicalism (like epiphenomenalism or eliminative materialism). Conclusion: A predominant group of project-solutions is adopted including complementary combination of contemporary forms of physicalism: identity theory of mind applied to mental events and brain processes; supervenience principle applied to other mental phenomena. Biomed Rev 2011; 22: 65-76.

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“…The mechanism of action of the class of small regulatory RNA molecules makes them appropriate for investigation as a potential therapeutical tool in patients suffering from such disturbances. 2 There is a growing body of evidence that DNA methylation profi le can be linked with specifi c alels associated with affective disorders. For example T polimorfi sm of C677T in methylhydrofolat reductase gene (MTHFR), recently associated with depressive illness.…”

Section: Microrna and Psychiatric Disordersmentioning

confidence: 99%

Epigenetic aspects in schizophrenia etiology and pathogenesis

Popov¹,

Stoyanova²,

Madzhirova³

et al. 2012

Folia Medica

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Epidemiological evidence suggests that etiology of schizophrenia may involve both the influence of genetic factors specific for the individual and the impact of the environment. It is quite likely that a crucial role in the disease development is played by molecular mechanisms mediating the interaction between genes and environment. Modern research have shown that epigenetic mechanisms or chemical modifications of deoxyribonucleic acids (DNA) and histone proteins remain unstable throughout life and can be changed by environmental factors. Thus the epigenetic mechanisms outline an attractive molecular hypothesis of the environment modelling role and the environmental contribution to schizophrenia progression. We give in the present study a general outline of schizophrenia as a pathological entity and discuss the role and involvement of environment versus genetic determinant (nature versus nurture) in the pathophysiolgical processes. Additionally, we focus on DNA methylation discussing the evidence for the role of that process in schizophrenia. Thirdly, we review the post-translational histone modifications and their role in schizophrenia. These investigations might surely lead further to the development of epigenetic therapy that looks promising in regard to symptom alleviation and the disease-associated cognitive deficit.

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The possibility of evidence-based psychiatry: depression as a case

Cited by 36 publications

References 49 publications

Translational Functional Neuroimaging in the Explanation of Depression

Translational Functional Neuroimaging in the Explanation of Depression

A linkage of mind and brain: towards translational validity between neurobiology and psychiatry

Epigenetic aspects in schizophrenia etiology and pathogenesis

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