The possibility of using magnetic nanoparticles to increase the therapeutic efficiency of Herceptin antibody

Rasaneh, Samira; Dadras, Maryam-Rahele

doi:10.1515/bmt-2014-0192

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…Such a carrier allows concentrating the drug, which can be driven to a defined target site by local application of an external direct current magnetic field. This approach offers also the possibility of monitoring drug delivery by magnetic resonance imaging (MRI) (Jain et al, ), improving drug release, or increasing the functionality of the grafted antitumor by magnetic hyperthermia (Bear et al, ; Rananeh and Dadras, ). Magnetic iron oxide NPs, that is, magnetite and maghemite, have attracted the most interest for these applications.…”

Section: Introductionmentioning

confidence: 99%

Coupling tumor necrosis factor‐related apoptosis‐inducing ligand to iron oxide nanoparticles increases its apoptotic activity on HCT116 and HepG2 malignant cells: effect of magnetic core size

Belkahla

Haque

Revzin

et al. 2019

J of Interdiscip Nanomed

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered as a potential anticancer agent owing to its selectivity for malignant cells. However, its clinical use remains limited because of its poor efficacy. Attempts to increase its antitumor activity include, among others, its functionalization by nanoparticles (NPs). In the present study, TRAIL was grafted onto magnetic spinel iron oxide NPs of defined core size, 10 and 100 nm on average, to see whether the size of the resulting nanovectors, NV10 and NV100, respectively, might affect TRAIL efficacy and selectivity. Apoptosis induced by NV10 and NV100 was higher than by TRAIL alone in both HCT116 and HepG2 cells. At equimolar concentrations, neither the nanovectors nor the corresponding NPs displayed cytotoxicity towards normal primary hepatocytes or TRAIL receptor-deficient HCT116 cells. NV100 exhibited superior proapoptotic activity than NV10, as evidenced by methylene blue and annexin V staining. Consistently, both caspase activation and TRAIL deathinduced signaling complex formation, as assessed by immunoblot analysis, were found to be increased in cells treated with NV100 as compared with NV10 or TRAIL alone. These results suggest that the size of NPs is important when TRAIL is vectorized for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Coupling tumor necrosis factor‐related apoptosis‐inducing ligand to iron oxide nanoparticles increases its apoptotic activity on HCT116 and HepG2 malignant cells: effect of magnetic core size

Belkahla

Haque

Revzin

et al. 2019

J of Interdiscip Nanomed

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“…Although antitumor drugs have the ability to inhibit the proliferation of cancer cells, the free spread of these small molecules to normal organs may result in serious systematic toxicity after long-term usage [ 1 , 2 , 3 , 4 ]. Different approaches have been employed to improve the therapeutic efficiency of anticancer drugs [ 5 , 6 , 7 ]. Among them, Glutathione (GSH)-sensitive polymeric nanoparticles for tumour-targeted delivery of anticancer drugs have attracted more and more attention in recent years due to several advantages, such as improving the stability and solubility of drugs, avoiding premature leaking in the blood stream and selective drug release enhancement in target tissues or cells, and increasing the circulation time in the physiological environment etc.…”

Section: Introductionmentioning

confidence: 99%

Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia

et al. 2018

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For enhanced intracellular accumulation of 6-mercaptopurine (6-MP) in leukemia, a folate receptor-targeted and glutathione (GSH)-responsive polymeric prodrug nanoparticle was made. The nanoparticles were prepared by conjugating 6-MP to carboxymethyl chitosan via a GSH-sensitive carbonyl vinyl sulfide linkage, ultrasonic self-assembly and surface decoration with folate. The TEM graphs shows that the as-synthesized nanoparticles are spherical with a particle size of 170~220 nm. In vitro drug release of nanoparticles demonstrated acceptable stability in PBS containing 20 μM GSH at pH 7.4. However, the cumulative drug release rate of the samples containing 20 mM and 10 mM GSH medium reached 78.9% and 64.8%, respectively, in pH 5.0 at 20 h. This indicated that this nano-sized system is highly sensitive to GSH. The inhibition ratio of folate-modified nanoparticles compared to unmodified nanoparticles was higher in cancer cells (human promyelocytic leukemia cells, HL-60) while their cytotoxicity was lower in normal cells (mouse fibroblast cell lines, L929). Furthermore, in vitro cancer cell incubation studies confirmed that folate-modified nanoparticles therapeutics were significantly more effective than unmodified nanoparticles therapeutics. Our results suggest that folate receptor-targeting and GSH-stimulation can significantly elevate tumour intracellular drug release. Therefore, folate-modified nanoparticles containing chemoradiotherapy is a potential treatment for leukemia therapy.

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“…First, they could be magnetically guided to the conducting airway surfaces to improve targeting and help the gene vector particles reside in the desired conducting airway regions; and secondly, the magnetic force may also assist the LV vector particles to move through the surface layers (mucus, secretions and ASL) to the cell layer 6 . MP have been extensively used in cancer therapy as a targeted drug-delivery vehicle when conjugated with antibodies, chemotherapeutics, or other small molecules that attach to cell membranes or bind to relevant cell surface receptors and accumulate at the tumor site in the presence of a static magnetic field 7 . Other “hyperthermic” techniques are designed to heat up the MP when exposed to an oscillating magnetic field, thereby destroying the tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging

Donnelley

Cmielewski

Morgan

et al. 2022

Sci Rep

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Gene vectors to treat cystic fibrosis lung disease should be targeted to the conducting airways, as peripheral lung transduction does not offer therapeutic benefit. Viral transduction efficiency is directly related to the vector residence time. However, delivered fluids such as gene vectors naturally spread to the alveoli during inspiration, and therapeutic particles of any form are rapidly cleared via mucociliary transit. Extending gene vector residence time within the conducting airways is important, but hard to achieve. Gene vector conjugated magnetic particles that can be guided to the conducting airway surfaces could improve regional targeting. Due to the challenges of in-vivo visualisation, the behaviour of such small magnetic particles on the airway surface in the presence of an applied magnetic field is poorly understood. The aim of this study was to use synchrotron imaging to visualise the in-vivo motion of a range of magnetic particles in the trachea of anaesthetised rats to examine the dynamics and patterns of individual and bulk particle behaviour in-vivo. We also then assessed whether lentiviral-magnetic particle delivery in the presence of a magnetic field increases transduction efficiency in the rat trachea. Synchrotron X-ray imaging revealed the behaviour of magnetic particles in stationary and moving magnetic fields, both in-vitro and in-vivo. Particles could not easily be dragged along the live airway surface with the magnet, but during delivery deposition was focussed within the field of view where the magnetic field was the strongest. Transduction efficiency was also improved six-fold when the lentiviral-magnetic particles were delivered in the presence of a magnetic field. Together these results show that lentiviral-magnetic particles and magnetic fields may be a valuable approach for improving gene vector targeting and increasing transduction levels in the conducting airways in-vivo.

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The possibility of using magnetic nanoparticles to increase the therapeutic efficiency of Herceptin antibody

Abstract: The good results in mice indicated that Herceptin-loaded iron oxide nanoparticles with external magnetic field have good potential for use in humans as a targeted drug delivery that needs more investigation.

Cited by 10 publications

References 22 publications

Coupling tumor necrosis factor‐related apoptosis‐inducing ligand to iron oxide nanoparticles increases its apoptotic activity on HCT116 and HepG2 malignant cells: effect of magnetic core size

Coupling tumor necrosis factor‐related apoptosis‐inducing ligand to iron oxide nanoparticles increases its apoptotic activity on HCT116 and HepG2 malignant cells: effect of magnetic core size

Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia

Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging

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