The Possible Ameliorative Effect of Curcumin on Atrazine-Induced Oxidative Stress, DNA Damage, Mitochondrial Dysfunction, and Apoptosis in the Kidney of Adult Male Albino Rats

Abstract

All rights reserved. Introduction trazine (2-chloro-4-ethylamino-6isopropylamino-s-triazine) is a triazine herbicide used worldwide to control grasses and weeds in a variety of crop plantations, especially corn, maize and cereals, as well as different types of fruits (Lasserre, et al., 2009; Zhao, et al., 2014). Human exposure includes occupational and non occupational exposure. Occupational exposure occurs through both inhalation and dermal absorption during its manufacture, formulation as well as handling. Non occupational exposure may include consumption of contaminated fish as it bioaccumulates in fish (Ross, et al., 2009).

Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment

“…Pretreatment with curcumin in rats against ATZ toxicity showed positive results by improving the anti-oxidant effect in hepato-renal injury [ 77 ]. In male albino rats, curcumin and ATZ co-supplementation prevented DNA lysis, oxidative damage, apoptosis, and mitochondrial dysfunction [ 118 ]. Curcumin administration in rats prevented the ATZ exposure-induced alterations in reproductive hormones and testicular injury [ 119 ].…”