The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder

Rezaeimanesh, Nasim; Saeedi, Roghayyeh; Sahraian, Mohammad Ali; Jahromi, Soodeh Razeghi; Moghadasi, Abdorreza Naser

doi:10.1016/j.msard.2020.102132

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…Dietary risk factors associated with NMOSD progression have been identified in previous studies 6 , 14 , though the evidence was insufficient to establish causal roles. A cross-sectional study was conducted to determine the type of diet mostly associated with the incidence of NMOSD.…”

Section: Introductionmentioning

confidence: 96%

Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum disorders: a Mendelian-randomization study

Wang¹,

Lin²,

Wu³

et al. 2023

Sci Rep

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Neuromyelitis optica spectrum disorders (NMOSD) are severe inflammatory disorders of the central nervous system targeting aquaporin‐4 (AQP4). The risk factors for NMOSD remain to be determined, though they may be related to diet and nutrition. This study aimed to explore the possibility of a causal relationship between specific food intake and AQP4-positive NMOSD risk. The study followed a two-sample Mendelian randomization (MR) design. Genetic instruments and self-reported information on the intake of 29 types of food were obtained from a genome-wide association study (GWAS) on 445,779 UK Biobank participants. A total of 132 individuals with AQP4-positive NMOSD and 784 controls from this GWAS were included in our study. The associations were evaluated using inverse-variance-weighted meta-analysis, weighted-median analysis, and MR-Egger regression. A high consumption of oily fish and raw vegetables was associated with a decreased risk of AQP4-positive NMOSD (odds ratio [OR] = 1.78 × 10−16, 95% confidence interval [CI] = 2.60 × 10−25–1.22 × 10−7, p = 0.001; OR = 5.28 × 10−6, 95% CI = 4.67 × 10−11–0.598, p = 0.041, respectively). The results were consistent in the sensitivity analyses, and no evidence of directional pleiotropy was observed. Our study provides useful implications for the development of AQP4-positive NMOSD prevention strategies. Further research is needed to determine the exact causal relationship and mechanisms underlying the association between specific food intake and AQP4-positive NMOSD.

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Section: Introductionmentioning

confidence: 96%

Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum disorders: a Mendelian-randomization study

Wang¹,

Lin²,

Wu³

et al. 2023

Sci Rep

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Protective Role of Vitamin B6 Against Teratogenic Effects Induced by Lead in Chick Embryo

Ahmad,

Kanwal,

Inayat

et al. 2024

Birth Defects Research

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BackgroundHeavy metals like lead (Pb) have been used by humans for a very long time, but throughout the industrial revolution, their use expanded, increasing exposure to the metal. Lead, however, has no biological purpose in the human body and is hazardous when it gets into soft tissues and organs. Lead is still used in a variety of industries, including battery manufacturing and car maintenance, despite efforts to limit its usage.ObjectiveThis study investigates the teratogenic and morphometric effects of lead on chick embryos and the potential ameliorative effects of vitamin B6.MethodsTwo hundred fertilized eggs from the golden black chicken were divided into four groups: control, lead acetate, vitamin B6, and lead + vitamin B6.ResultsOn the 14th day, embryos were analyzed. Significant reductions in body weight and size were observed in the lead‐exposed group (33.93 ± 1.27 g) compared to the control (41.12 ± 0.97 g). Pronounced deformities included rudimentary beaks, protruding eyes, tridactyl limbs, hydrocephaly, and neck deformities. Appendicular deformities like phocomelia, amelia, and abnormal phalanges growth were also noted. Vitamin B6 demonstrated therapeutic benefits, significantly improving mean embryo weight in the Lead + Vitamin B6 group (42.37 ± 0.99 g). The lead‐exposed group showed a reduction in maxilla length (3.61 ± 1.30 mm) compared to the Lead + Vitamin B6 group (7.57 ± 0.79 mm). This group also showed reduced severity of muscular dystrophy and bone thinning, with signs of recovery in beak and bone sizes.ConclusionsThe study highlights vitamin B6's beneficial impact in mitigating lead's toxic effects on chick embryonic development.

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Protective role of vitamin B6 against mitochondria damage in Drosophila models of SCA3

Nan

Lin

Cui

et al. 2021

Neurochemistry International

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The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder

Cited by 4 publications

References 25 publications

Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum disorders: a Mendelian-randomization study

Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum disorders: a Mendelian-randomization study

Protective Role of Vitamin B6 Against Teratogenic Effects Induced by Lead in Chick Embryo

Protective role of vitamin B6 against mitochondria damage in Drosophila models of SCA3

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