The Possible Effect of Vitamin D on Uric Acid Levels in Diabetic Patients

Atalay, Eray; Korlaelçi, Fırat; Gürsoy, Gül; Karabağ, Yavuz; Yıldız, Mehmet; Erdoğdu, Halil İbrahim; Kıvrak, Yüksel

doi:10.5336/worldclin.2017-55375

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Uric acid has been known as an independent risk factor for the development of cardiovascular and renal diseases, as well as a predictor of renal injury [30,31] . One study has reported the association between vitamin D insufficiency and high uric acid level in many diseases, including type 2 diabetes mellitus [32] . Another study has disclosed that vitamin D insufficiency was significantly related to elevated uric acid among postmenopausal, but not premenopausal Chinese Han Women [25] .…”

Section: Discussionmentioning

confidence: 99%

Calcitriol Treatment Attenuates Uric Acid-Induced Kidney Injury via Super Oxide Dismutase-1 (SOD-1) Upregulation and Fibrosis Reduction

Romi

Arefian

Setyaningsih

et al. 2021

ibj

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Section: Discussionmentioning

confidence: 99%

Calcitriol Treatment Attenuates Uric Acid-Induced Kidney Injury via Super Oxide Dismutase-1 (SOD-1) Upregulation and Fibrosis Reduction

Romi

Arefian

Setyaningsih

et al. 2021

ibj

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“…There is evidence from studies by Sipahi (2017) and Atalay (2017) that in the kidneys vitamin D affects the phosphate ion reabsorption, increasing it and increasing its blood concentration (hyperphosphatemia) in the course of phosphorous exchange, and this effect is also opposed to the parathormone effect (24,25).…”

Section: Vitamin D: Role Effect Physiological Importancementioning

confidence: 99%

Effects of vitamin D on the renin-angiotensin system

Toleкova¹

2019

TJS

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The renin-angiotensin-aldosterone system (RAAS) is a complex endocrine system of enzymes, proteins and peptides that occupies a key position in the regulation of a number of important physiological processes, such as arterial pressure, water and electrolyte homeostasis. Its activity, flow and regulation are affected by a large number of mediators, substances and diseases one of which is vitamin D. Vitamin D is involved in the regulation of many physiological processes with great importance. Vitamin D deficiency is associated with an increased risk of impaired renal function, cardiovascular disease, diabetes mellitus, metabolic disorders, affecting RAAS and other pathways

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“…This is supported by the findings of Atalay et al, who reported that 25 (OH) vitamin D deficiency was associated with higher levels of serum UA in a cross-section of 100 T2DM patients in Turkey. [28] Intriguingly, an interventional study on seventy-one individuals with prediabetes showed that vitamin D supplementation reduced serum UA levels in participants with hyperuricemia. [29] The exact mechanism that explains the negative correlation between vitamin D and UA levels is not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Reduces the Activity of Adenosine Deaminase and Oxidative Stress in Patients with Type Two Diabetes Mellitus

Alfaqih,

Ababneh,

Mhedat

et al. 2024

Molecular Nutrition Food Res

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ScopePatients with Type 2 diabetes mellitus (T2DM) have lower levels of vitamin D. An elevation in uric acid (UA) contributes to T2DM via an increase in oxidative stress. Adenosine deaminase (ADA) is an enzyme of the purine degradation pathway. It is hypothesized that a reduction of ADA activity via vitamin D supplementation reduces UA and oxidative stress.Methods and resultsA total of 162 participants (81 with T2DM and 81 controls) are enrolled in a case–control study. A follow‐up interventional study is performed on 30 patients with vitamin D deficiency. These patients receive 50 000 IU (international units) of vitamin D3 on a weekly basis for 12 weeks. This intervention is followed by the measurement of several markers. T2DM patients has higher ADA activity, UA, and lipid peroxidation but lower 25‐hydroxy‐vitamin D (25 (OH) vitamin D) and GSH/GSSG ratio (p < 0.05). Vitamin D supplementation results in a reduction of ADA activity and UA levels (p < 0.05) along with an increase in GSH/GSSG ratio (p < 0.05).ConclusionThe results highlight the presence of an axis in T2DM patients between ADA, UA, and oxidative stress. Modulation of this axis can be achieved by clinically approved vitamin D supplementation protocols.

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The Possible Effect of Vitamin D on Uric Acid Levels in Diabetic Patients

Cited by 5 publications

References 37 publications

Calcitriol Treatment Attenuates Uric Acid-Induced Kidney Injury via Super Oxide Dismutase-1 (SOD-1) Upregulation and Fibrosis Reduction

Calcitriol Treatment Attenuates Uric Acid-Induced Kidney Injury via Super Oxide Dismutase-1 (SOD-1) Upregulation and Fibrosis Reduction

Effects of vitamin D on the renin-angiotensin system

Vitamin D Reduces the Activity of Adenosine Deaminase and Oxidative Stress in Patients with Type Two Diabetes Mellitus

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