The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish

Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka (Oryzias sinensis): A Study from Laboratory to Field

“…21 Jin et al found that zebrafish embryos exposed to 1500 nM and higher concentrations of BHPF exhibited obvious phenotypic defects, such as bent spines, pericardial edema, yolk sac malformation, absence of a swimming bladder, small eyes, tail malformation, and double heads, and the malformation rates were significantly increased in a dose-dependent manner. 18 These previous findings, as well as our data in this study, demonstrated the teratogenicity of BHPF on fishes. Considering that the defects and malformations in embryos and larvae would be induced at low concentrations of BHPF close to some of that detected in real environments (Table S3), we also investigated the developments of embryos and larvae collected from wild fish and found similar defects and malformations (Figure S4).…”

“…Subsequently, Mi et al found that acute BHPF exposure (1, 2, 5, 10, and 20 μM) could retard the early embryonic development before 24 hpf and resulted in a morphological phenotype, including the decreased body length and the decreased head area and eye area at 72 hpf . Jin et al found that zebrafish embryos exposed to 1500 nM and higher concentrations of BHPF exhibited obvious phenotypic defects, such as bent spines, pericardial edema, yolk sac malformation, absence of a swimming bladder, small eyes, tail malformation, and double heads, and the malformation rates were significantly increased in a dose-dependent manner . These previous findings, as well as our data in this study, demonstrated the teratogenicity of BHPF on fishes.…”

Species Differences in Response to Binding Interactions of Bisphenol A and its Analogs with the Modeled Estrogen Receptor 1 and In Vitro Reporter Gene Assay in Human and Zebrafish

“…These chemicals have been reported to have endocrine disruptor potential by exhibiting anti‐ or estrogenic activities in humans (Keminer et al, 2020). In addition, BPFL showed an anti‐estrogenic effect in mice and zebrafish, and hormetic effects on regulating the hypothalamic–pituitary–thyroid axis in zebrafish (Jin et al, 2021; Mi et al, 2019; Zhang et al, 2017). However, there is still a lack of studies on their estrogenic disruptive activities and their modes of action in aquatic species.…”

Contaminants of emerging concern and aquatic organisms: the need to consider hormetic responses in effect evaluations

“…A further survey of the literature for the purpose of this study revealed ample evidence suggestive of hormesis for numerous aquatic organisms and various pollutants and emerging contaminants in dozens of publications, of which only a few selected examples are cited here (older examples can also be traced in the therein references). These examples include a plethora of species, such as of algae (microphytes) [38][39][40][41][42][43][44][45][46][47][48][49] , aquatic flowering plants [50] , organism-attached biofilms [51] , crustaceans [52][53][54][55][56][57] , cyanobacteria [49,[58][59][60][61] , fishes [62][63][64][65][66][67][68][69] , macrophytes [70][71][72][73][74][75] , marine polychaete [76] , mollusks (e.g., clams and mussels) [77,78] , periphyton [79] , phytoplankton [80] , sea anemones [81,82] , and snails [83] . Responses suggestive of hormesis were found for molecular (molecules...…”

“…Responses suggestive of hormesis were found for molecular (molecules involved in oxidative stress), cellular (e.g., growth and density), and whole-organism (e.g., growth and body mass) endpoints, as well as endpoints suggesting potential sub-NOAEL effects on organismic interactions, such as via altered feeding activity [83] . Such responses were induced by chemicals such as antibiotics/antifungals [38,39,42,45,50,51,67,70,71,75] , steroid hormones [41,83] , and other human drugs [63,69] , bisphenol A and its substitutes [66] , chemical leached from disposed light sticks [55] , electroplating processemitted particulate matter [40] , effluents from textile-dyeing wastewater treatment plants [46] , fullerene crystals (nC 60 ) [57] , metals and ionic liquids [62,77,81,82] , micro/nanoplastics and their leachates [43,44,47,53,60,64,80,84] , engineered nanomaterials [58,59,61,65] , pesticides [48,49,52,56,[72][73][74]79,84] , phthalic acid esters ...…”