The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats

Abdel-Aziz, Nahed; Badawy, Ahmad; Elgamal, Ahmad Abdallah Elsayed; El‐Belely, Ehab F.; Hammad, Aly; Zakria, Abeer

doi:10.21608/ajnsa.2022.125836.1558

Cited by 3 publications

(5 citation statements)

References 24 publications

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“…On the other hand, Khattab et al [30] didn't notice any significant differences in the levels of ALT and AST in blood serum of Barkhiya ewes that were treated with spirulina powder for 8 weeks. Our results also contradicted the study of Badawy et al [31], who observed a significant decrease in level of ALT enzyme without affecting the level of AST in animals treated with SP for a week. Also, Alghonaim et al [32] didn't find any significant effect of SP on liver enzymes on day 90 of the experiment.…”

Section: Alanine Aminotransferase (Alt)contrasting

confidence: 99%

Effect of Lipid Profile and Liver Enzymes by Adding Spirulina Platensis to Feed with Different Levels of Protein in Local Male Sheep

Yas Khudair,

Alwan Hamad

2024

IOP Conf. Ser.: Earth Environ. Sci.

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This study was carried out in the animal field of the College of Veterinary Medicine at Tikrit University, and continued for 90 days from 10/2/2022 to 12/31/2022, using two levels of spirulina platensis (SP), 8 and 12%, to raise the value of the diet with low protein (LP) content, as well as reducing the harmful effect of high protein (HP) on the other hand in lamb diets and to investigate the effect of two levels using some lipid profile and liver enzymes in the blood of Iraqi lambs. 24 local lambs were used, purchased from the markets of Saladin Governorate - Iraq, and their ages ranged between 3 and 4 months, with an average starting weight of 20.5 ± 0.9 kg, by randomly distributing them into 6 treatments / 4 lambs for each treatment. As follows: The first treatment was HP (control 1). The second treatment was HP + 8 g SP/1 kg concentrated feed. The third treatment was HP + 12 g SP/1 kg concentrated feed. The fourth treatment was LP (control 2) and the fifth treatment was LP + 8 g SP/1 kg feed. Concentrate and the sixth treatment, LP + 12 g SP/1 kg concentrated feed. The results of the study indicated that adding HP to the diet significantly (P<0.05) affected the level of aspartate aminotransferase (AST) on day 45, while on day 90 it affected the level of cholesterol (CHOL) and low-density lipoprotein (LDL). Adding LP also led to a significant (P<0.05) effect on high-density lipoprotein (HDL) levels on day 90 of the experiment. The interaction between HP and SP at a level of 12 g showed significant (P<0.05) differences in the levels of CHOL, triglycerides (TG), very low-density lipoprotein (VLDL) and AST on day 45, while on day 90 only CHOL and LDL had an effect. Supplementing both LP and 8g SP helped with the effects on HDL at day 90.

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Section: Alanine Aminotransferase (Alt)contrasting

confidence: 99%

Effect of Lipid Profile and Liver Enzymes by Adding Spirulina Platensis to Feed with Different Levels of Protein in Local Male Sheep

Yas Khudair,

Alwan Hamad

2024

IOP Conf. Ser.: Earth Environ. Sci.

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“…The histological investigations of C. vulgaris and/or Orange peels supplementation in irradiated rats showed amelioration in liver fibrosis progression in accordance with the finding obtained by Abdel-Aziz et al 88 It could be attributed to amelioration of oxidative stress status and targeting TGF-β1 signaling pathway. 89…”

Section: Histopathological Observationsupporting

confidence: 89%

“…A high dose of ionizing radiation caused a significant (p ≤ 0.05) rise in ALT, AST, Urea, and Creatinine (the increased percentages recorded were 43.1%, 35.4%, 156.6%, and 183%, respectively as compared with the control group), in agreement with the data obtained by Darwish et al 53 and Ahmad et al 54 This increase could be attributed to the interaction of cellular membranes with the free radicals produced by gamma rays directly or indirectly which cause change in tissue permeability and enhancement of enzyme movement from its subcellular production sites to the extracellular fluid and consequently to blood. 55 However supplementation with orange peels and C. vulgaris cause a remarkable improvement (the percentages recorded were −7.5%, −7.1%, 33.2%, and 18.6%, respectively as compared with the control group), as shown in Table 2; in accordance with the data obtained by Badawya et al 56,57 and Ahmed et al 58 This effect may be due to the high quantities of phenolic compounds and their antioxidant capacities. 59…”

Section: The Effects On Liver and Kidney Functionssupporting

confidence: 86%

“…Thrall et al 72 found decrease in PLT with exposure to ionizing radiation due to consumption of coagulation factors and platelets throughout the body's blood vessels. Whereas, supplementation with orange peels and C. vulgaris induced a notable amelioration (the decreased percentages recorded were −51.2%,−15.3%, −4.0%, and −13.7% respectively as compared with the control group), as shown in Table 4; the recorded improvement was in accordance with Badawya et al 56 and Abd El-Gwaad et al 57 It could be attributed to the antioxidant contents of C. vulgaris and orange peels. 13,73 3.1.4 | The effects on TGF-β1 and NOX2/NOX4 signaling pathways A high dosage of ionizing radiation (2 Gy twice per week for up to 2 weeks for total fractionated 8 Gy) resulted in a significant (p ≤ 0.05) increase in the expression of the TGF-β1 and NOX2/NOX4 Signaling Pathways (TGF-β1: 5.3 fold, NOX2: 8 fold, and NOX4: 6.4 fold in comparison to normal control).…”

Section: The Effects On Hematological Parameterssupporting

confidence: 86%

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Orange peels and Chlorella vulgaris supplementation ameliorate gamma radiation‐induced oxidative stress by regulating TGF‐β and NOX2/NOX4 signaling pathways

Abdelrahman,

Mohammed,

Badawy

et al. 2023

Cell Biochemistry & Function

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Numerous studies revealed that Chlorella vulgaris and orange peels are potential sources for many valuable compounds such as flavonoids, which are natural polyphenols with antioxidant capacities that lessen oxidative stress via suppressing ROS levels. Thus, this study was designed to investigate their radioprotective efficiency either alone or in combination as natural food supplements. Sixty‐four male Albino rats were divided into eight groups (n = 8) as follows: control, orange peel (10% in diet), C. vulgaris (1% in diet), orange peel + C. vulgaris, gamma irradiated (2Gy twice per week up to 8Gy), orange peel + gamma irradiation, C. vulgaris + gamma irradiation, and orange peel + C. vulgaris + gamma irradiation. After the experiment, blood serums were collected for biochemical analysis, whole bloods were collected for blood picture, bone marrows were collected for GSH, MDA, TGF‐β, NOX2 and NOX4, and liver tissues were collected for histopathological evaluation. Current study revealed that exposure to gamma irradiation induced a significant disturbance in liver function markers (ALT and AST), kidney function markers (urea and creatinine), cholesterol and triglycerides levels in serum. In addition, a significant decrease in WBCs, RBCs, PLT, and Hb in blood of irradiated rats. Moreover, a significant elevation in TGF‐β, NOX2, NOX4 activities, and MDA level, while showed a marked decrease in GSH concentration. Furthermore, hepatic inflammation appeared in the histopathological examination. Orange peels or C. vulgaris treatments showed acceptable amelioration in all measured parameters, combination between orange peels and C. vulgaris showed statistically significant additive amelioration in radiation induced disturbance.

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“…This was agreed with (Abd el-Aziz et al, 2022) who reported that oral administration of Chlorella vulgaris and Spirulina platensis increased RBCs, Hb, hematocrit and platelet count. This may be attributed to spirulina playing an important role in the erythropoiesis process (Badawy et al, 2022) and on the same side, Chlorella vulgaris improved heamato-biochemical parameters (Sayed et al, 2021) and also may attribute to feed with protein can improve the number of RBCs. CV and SP are rich in proteins and other nutrients, similar to that reported by Siman Juntak et al (2022).…”

Section: Discussionmentioning

confidence: 97%

Protective Effect of Chlorella vulgaris and Spirulina platensis against ThioacetamideInduced Hepatorenal Toxicity in Male Rats

Elmeleh,

Attia,

Elgendy

2023

Journal of Current Veterinary Research

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The present inquiry evaluated the possible pharmacological effects of Chlorella vulgaris (CV) and Spirulina platensis (SP) with special reference to their hepatorenal protective effect as well as their antioxidant activities against thioacetamide (TAA) acute toxicity. Thirty-six male Wister albino rats, weighing from 100 to 120 gm were applied in the present study. Rats were randomly allocated into 6groups each of 6 animals. Group I was maintained as the control healthy group. It was administrated distilled water orally for one month and normal saline at a dose of 1 ml IP. On the last two days of the experiment. The other groups were allocated into 5 groups including A, B, C, D and E. Group A was used as a control intoxicated with thioacetamide at a dose of 300 mg/ kg b.wt. IP for two days with 24 hrs intervals before the end of the experiment. Group B was stated as a standard protected group and it was treated with silymarin at a dose of 100 mg/kg b.wt. orally for one month. Group C was given Chlorella vulgaris orally at a quantity of 400 mg/kg b.wt. daily, for one month. Group D was given Spirulina platensis at a dose of 400 mg /kg b.wt. Orally daily for one month. Group E was given CV &SP at doses of 400 mg /kg b.wt each orally daily for one month. Groups B, C, D, and E were intoxicated with thioacetamide (TAA), at an amount of 300mg/kg b.wt. IP for two days with 24 hrs intervals at the end of the month. Toxicity of rats with thioacetamide substantially elevated the levels of alanine transferase and aspartate aminotransferase, serum urea, creatinine, and uric acid in addition to increased malon-di-aldehyde concentration. However, it significantly decreased total proteins, and total antioxidant capacity concentrations and decreased blood parameters. As well as it induced histopathological alterations in hepatic and renal tissue designs (delete). On the other hand, oral administration of Chlorella vulgaris and Spirulina platensis ameliorated TAA-induced biochemical, pathological, and histopathological changes in hepatic tissues and renal tissues. This study stated that these algae attenuate thioacetamide and protect against hepatorenal toxicity, via their antioxidant properties.

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The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats

Cited by 3 publications

References 24 publications

Effect of Lipid Profile and Liver Enzymes by Adding Spirulina Platensis to Feed with Different Levels of Protein in Local Male Sheep

Effect of Lipid Profile and Liver Enzymes by Adding Spirulina Platensis to Feed with Different Levels of Protein in Local Male Sheep

Orange peels and Chlorella vulgaris supplementation ameliorate gamma radiation‐induced oxidative stress by regulating TGF‐β and NOX2/NOX4 signaling pathways

Protective Effect of Chlorella vulgaris and Spirulina platensis against ThioacetamideInduced Hepatorenal Toxicity in Male Rats

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