The possible protective effect of L-arginine against 5-fluorouracil-induced nephrotoxicity in male albino rats

Badawoud, Mohammed H.; Elshal, Eman B.; Zaki, Azza I.; Amin, Hanan A.

doi:10.5603/fm.a2017.0037

Cited by 17 publications

(16 citation statements)

References 37 publications

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“…In the present study, the administration of L-arginine protects the kidney function from Cd and Pb intoxication as indicated by significant restoration of serum urea, uric acid, and creatinine. This corroborates with the findings of Badawoud et al (2017) in which L-arginine has been reported to protect 5-fluorouracil-induced nephrotoxicity through its antioxidant capacity. Cd and Pb-induced kidney dysfunction was most likely attributed to oxidant/antioxidant imbalance in the kidney which manifested by a significant increase of the lipid peroxidation biomarker MDA and a significant decrease in the activities of the antioxidant enzymes (SOD, CAT) and GSH level.…”

Section: Discussionsupporting

confidence: 92%

Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats

Embaby

Marghani

Elghareeb

et al. 2020

Kafrelsheikh Veterinary Medical Journal

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Objective: This study was conducted to investigate the protective effect of L-arginine (L-Arg) on renal damage induced by cadmium (Cd) and lead (Pb) toxicities in rats. Methods: Thirty-six healthy mature male albino rats were allocated into six experimental groups (n=6/group): control group, L-arginine group (L-Arg) administered 200 mg/kg b.wt L-Arg, cadmium chloride group (Cd) received 5 mg/kg b.wt Cd chloride, lead acetate group (Pb) received 25 mg/kg b.wt Pb acetate, L-Arg + Cd chloride group (L-Arg + Cd) received L-Arg 30 minutes prior to Cd chloride, and L-Arg + Pb acetate group (L-Arg + Pb) received L-Arg 30 minutes prior to Pb acetate. All treatments were given orally once daily for 15 days. Results: The results revealed that exposure of rats to Cd chloride and Pb acetate resulted in a significant (p < 0.05) increase in serum creatinine, urea, uric acid, and renal malondialdehyde (MDA) levels and a significant (p < 0.05) decrease in superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) activities in kidney and induced histopathological alterations in kidney tissue. However, pretreatment with L-Arg attenuated all deleterious effects induced by Pb and Cd. Conclusion: The present results support the hypothesis that the amino acid, L-arginine, is an efficient antioxidant capable of minimizing the hazard effects of cadmium chloride and lead acetate on the kidney.

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Section: Discussionsupporting

confidence: 92%

Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats

Embaby

Marghani

Elghareeb

et al. 2020

Kafrelsheikh Veterinary Medical Journal

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“…It also prevents renal toxicity of ethanol as manifested by morphological and histological studies in male rats [35] . Similarity, Badawoud1 et al, [36] reported that L-arginine at dose level 378 mg/rat/day for 4 weeks has effective ability to improve biochemical and histological changes in 5-5-fluorouracil nephrotoxicity, as glomerulus sclerosis, degeneration of convoluted tubules and interstitial fibrosis.…”

Section: Introductionsupporting

confidence: 60%

Modulation of monosodium glutamate induced histological injuries, histomorphometrical alterations and DNA damage in the mice hepatic and renal tissues by oral administration Nano-cerium oxide and L-arginine and their combination

Hamad¹,

Hamad

2020

Egyptian Journal of Histology

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Background: Monosodium glutamate is widely used as flavor enhancer/food additive. Many studies confirmed toxicity of monosodium glutamate even if in low concentrations especially in hepatic and renal organs. Therefore, our study aimed to examine ameliorative role of Nano-cerium oxide and L-arginine and their combination on the hepatic and renal toxicity induced by monosodium glutamate. Materials and Methods: Fifty mice were divided into five groups; 1st group served as control group; 2nd group treated oral with monosodium glutamate; animals of the 3rd group were administrated with monosodium glutamate and L-arginine. The 4th group was treated with monosodium glutamate and Nano-cerium oxide; and mice of the 5th group were treated with monosodium glutamate, L-arginine and Nano-cerium oxide. After 14 days, hepatic and renal tissues were removed for histological and histomorphometrical examinations Results: Histological examination revealed hepatic and renal damages for animals treated with monosodium glutamate as well as highly significant declining of DNA content compared to control group. Administration of Nano-cerium oxide or L-argentine alone induced ameliorations of the hepatic and renal injuries induced by administration of monosodium glutamate but some pathological alterations still present. It also caused moderate improvement in the DNA content but still not reaches to normal value. Combined administration of Nano-cerium oxide and L-arginine caused marked ameliorations of the hepatic and renal changes induced by monosodium glutamate. Conclusions:The combined uses of L-arginine and Nano-cerium oxide more effective in preventing the hepatic and renal toxicity induced by monosodium glutamate in male albino rats than when they uses separately.

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“…Drug-induced renal injury is one of common causes of acute kidney injury and is characterized by high patient morbidity and mortality [18][19][20]. In this context, 5-FU induced glomeruloscelerosis, degeneration of convoluted tubules, and interstitial fibrosis with ultimate renal dysfunction [21].…”

Section: Introductionmentioning

confidence: 99%

Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and γ-GCS

et al. 2021

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The development of the field of nanotechnology has revolutionized various aspects in the fields of modern sciences. Nano-medicine is one of the primary fields for the application of nanotechnology techniques. The current study sheds light on the reno-protective impacts of gold nano-particles; nanoGold (AuNPs) against 5-flurouracil (5-FU)-induced renal toxicity. Indeed, the use of 5-FU has been associated with kidney injury which greatly curbs its therapeutic application. In the current study, 5-FU injection was associated with a significant escalation in the indices of renal injury, i.e., creatinine and urea. Alongside this, histopathological and ultra-histopathological changes confirmed the onset of renal injury. Both gene and/or protein expression of nuclear factor erythroid 2–related factor 2 (Nrf-2) and downstream antioxidant enzymes revealed consistent paralleled anomalies. AuNPs administration induced a significant renal protection on functional, biochemical, and structural levels. Renal expression of the major sensor of the cellular oxidative status Nrf-2 escalated with a paralleled reduction in the renal expression of the other contributor to this axis, known as Kelch-like ECH-associated protein 1 (Keap-1). On the level of the effector downstream targets, heme oxygenase 1 (HO-1) and gamma-glutamylcysteine synthetase (γ-GCS) AuNPs significantly restored their gene and protein expression. Additionally, combination of AuNPs with 5-FU showed better cytotoxic effect on MCF-7 cells compared to monotreatments. Thus, it can be inferred that AuNPs conferred reno-protective impact against 5-FU with an evident modulatory impact on Nrf-2/Keap-1 and its downstream effectors, HO-1 and γ-GCS, suggesting its potential use in 5-FU regimens to improve its therapeutic outcomes and minimize its underlying nephrotoxicity.

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The possible protective effect of L-arginine against 5-fluorouracil-induced nephrotoxicity in male albino rats

Cited by 17 publications

References 37 publications

Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats

Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats

Modulation of monosodium glutamate induced histological injuries, histomorphometrical alterations and DNA damage in the mice hepatic and renal tissues by oral administration Nano-cerium oxide and L-arginine and their combination

Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and γ-GCS

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