The Possible Role of Adenosine Triphosphate in Chemical Transmission Between the Hypogastric Nerve Terminal and Seminal Vesicle in the Guinea-Pig

Nakanishi, Hironori; TAKEDA, Hiroshi

doi:10.1016/s0021-5198(19)31546-x

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…8 A later study showed that ATP was not only released from NANC nerves in the taenia coli but also from sympathetic nerves supplying smooth muscle. 19 These studies supported the concept of co-transmission of ATP with NA from sympathetic nerves. 20 The co-transmitter concept was initially resisted by the scientific community, but it is now wellestablished that every nerve in both the peripheral and central nervous systems utilizes ATP as a co-transmitter.…”

Section: The Adenosine and Purinergic Hypothesessupporting

confidence: 55%

“…Adenosine is broken down further by adenosine deaminase ( ADA ) to inosine and hypoxanthine and removed by the circulation 8 . A later study showed that ATP was not only released from NANC nerves in the taenia coli but also from sympathetic nerves supplying smooth muscle 19 . These studies supported the concept of co‐transmission of ATP with NA from sympathetic nerves 20 .…”

Section: More Than Just the Building Blocks Of Lifementioning

confidence: 86%

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Purinergic signaling and purine base metabolism at the crossroads between immunity, metabolism, and cancer: A review

et al. 2023

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In addition to its universally known role in transferring genetic material, DNA nucleotides and nucleosides are regarded as the most ancient form of extracellular signaling molecules. This unique signaling pathway was first reported by Dr. Albert Szent‐Györgyi in 1937 and established by Dr. Geoffrey Burnstock in 1972, who coined the term “purinergic signaling.” The significance of purinergic signaling is now recognized in various cellular processes, including immune responses. With an increased understanding of how changes in immunity impact cancer progression, the groundbreaking successes of immunotherapies, and emerging challenges facing patients receiving these treatments, in this review we revisit the history of purinergic signaling, provide a comprehensive summary of its impact on immune cells, and discuss the therapeutic potential of targeting this pathway for cancer treatment.

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Section: The Adenosine and Purinergic Hypothesessupporting

confidence: 55%

Section: More Than Just the Building Blocks Of Lifementioning

confidence: 86%

Purinergic signaling and purine base metabolism at the crossroads between immunity, metabolism, and cancer: A review

et al. 2023

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“…Present in all cells, ATP remains stored in vesicles at the synaptic endings and it is released after neuronal depolarization acting on the postsynaptic membrane at specific receptors, called purinoreceptors [54] , [55] , [56] . In addition, it can be released together with several neurotransmitters, such as acetylcholine (ACh), glutamate, norepinephrine, serotonin, and γ-amino butyric acid (GABA) [30] , [57] , [58] , [59] , [60] , [61] , [62] .…”

Section: Purinergic Systemmentioning

confidence: 99%

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

Simões

Basso

Kosvoski

et al. 2021

International Immunopharmacology

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The etiological agent of coronavirus disease (COVID-19) is the new member of the Coronaviridae family, a severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2), responsible for the pandemic that is plaguing the world. The single-stranded RNA virus is capable of infecting the respiratory tract, by binding the spike (S) protein on its viral surface to receptors for the angiotensin II-converting enzyme (ACE2), highly expressed in the pulmonary tissue, enabling the interaction of the virus with alveolar epithelial cells promoting endocytosis and replication of viral material. The infection triggers the activation of the immune system, increased purinergic signaling, and the release of cytokines as a defense mechanism, but the response can become exaggerated and prompt the so-called “cytokine storm”, developing cases such as severe acute respiratory syndrome (SARS). This is characterized by fever, cough, and difficulty breathing, which can progress to pneumonia, failure of different organs and death. Thus, the present review aims to compile and correlate the mechanisms involved between the immune and purinergic systems with COVID-19, since the modulation of purinergic receptors, such as A2A, A2B, and P2X7 expressed by immune cells, seems to be effective as a promising therapy, to reduce the severity of the disease, as well as aid in the treatment of acute lung diseases and other cases of generalized inflammation.

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Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses

Matsuoka

Yoshida

Ito

2022

Journal of Pharmacological Sciences

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The Possible Role of Adenosine Triphosphate in Chemical Transmission Between the Hypogastric Nerve Terminal and Seminal Vesicle in the Guinea-Pig

Cited by 8 publications

References 36 publications

Purinergic signaling and purine base metabolism at the crossroads between immunity, metabolism, and cancer: A review

Purinergic signaling and purine base metabolism at the crossroads between immunity, metabolism, and cancer: A review

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses

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