The possible role of cardiac atrial stretch receptors in the induction of changes in urine flow

Henry, James P.; Pearce, J. W.

doi:10.1113/jphysiol.1956.sp005483

Cited by 224 publications

(107 citation statements)

References 15 publications

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“…The magnitude and characteristics of these responses are similar to those previously observed in response to stretching the pulmonary vein-left 26P PHYSIOLOGICAL SOCIETY, NOVEMBER 1972 atrial junctions (Ledsome & Linden, 1968), distending the atrial appendages (Kappagoda, Linden & Snow, 1972b), or distending the left atrium (Henry & Pearce, 1956). It is therefore concluded that distension of either the right atrium or the superior vena caval-right atrial junction results in a reflex increase in urine flow and that the afferent path of the reflex is at least partially in the right vagus.…”

Section: Psupporting

confidence: 67%

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Communications

1973

The Journal of Physiology

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6PAPROCEEDINGS OF THE digital computers have eliminated the need for this intermediate step of data preparation and, leaving aside the question of cost and the time spent in programming, have made it possible to view spectra within a few seconds.Recently, special purpose analysers have become available which are even faster and require no programming. The demonstration is intended to show the advantages of one type of instrument (SAI-51A, Signal Analysis Industries Corp., New York) in the analysis of physiological muscle tremor. The particular feature of this intrument is that it uses digital sampling combined with some analogue processing. This results in such an increase in speed that it is possible to display the spectrum apparently continuously updated. The examination of signals in the frequency domain now becomes almost as direct as their usual display in the time domain. The value of this has already become evident, as will be demonstrated, in gaining some insight into the origin ofthe [8][9][10] Hz peak, which can be seen in the frequency spectrum of muscle tremor recorded during the maintenance of steady voluntary isometric contractions.

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Section: Psupporting

confidence: 67%

“…(Henry & Pearce, 1956;Ledsome & Linden, 1968). This communication reports the results of two investigations undertaken to determine the effects on urine flow of either distending the superior vena caval-right atrial junction or part of the right atrium.…”

Section: Pmentioning

confidence: 99%

Communications

1973

The Journal of Physiology

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“…2 were sufficient to establish that inflation of the balloon did produce a diuresis, but its size and variability made detailed investigations difficult and attempts to explain the mechanisms involved must be largely speculative. and Henry & Pearce (1956) suggest that the first stage in the mechanism is the stimulation of receptors in the left atrium.…”

Section: Discussionmentioning

confidence: 99%

“…Receptors in the pulmonary arteries and left atrium presumably discharged more frequently when a balloon was inflated to obstruct the mitral opening; Henry & Pearce (1956) recorded the discharge from a receptor in the left atrium. Also Henry & Pearce (1956) observed no diuresis when the left atrium was obstructed with the vagi blocked by cold, and we were unable to produce a diuretic response to balloon inflation after vagal section (Fig. 7).…”

Section: Atrial Distension and Diuresismentioning

confidence: 99%

The mechanisms by which distension of the left atrium produces diuresis in anaesthetized dogs

Ledsome¹,

O’Connor²

1961

The Journal of Physiology

102

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Recent reviewers primarily interested in renal (Smith, 1957) and cardiovascular physiology (Neil, 1960) have accepted a theory that distension of the left atrium of the heart sets up afferent impulses in the vagus nerves which decrease the release of antidiuretic hormone from the neurohypophysis, and so cause diuresis. The theory is within the general conception that the renal excretion of water and electrolytes is partly governed by the volume in some fluid compartment of the body. Support for this role of atrial receptors has been derived from the experiments of Henry, , who found that in anaesthetized dogs inflation of a balloon in the left atrium caused an increase in urine flow with a time course and other characteristics which could be accounted for by a diminished release of antidiuretic hormone. The paper of contains little evidence to support this interpretation. In view of the theoretical importance attached to them the experiments have been repeated and extended in this paper; whilst the main results are confirmed, the small and variable size of the response is emphasized and additional observations make untenable the explanation that the diuresis is due to decreased release of antidiuretic hormone. A preliminary account has already been published (Ledsome, Linden & O'Connor, 1961). METHODSThe experiments were carried out as described by . Dogs of 10-15 kg were given 15 mg morphine sulphate by subcutaneous injection and 1 hr later were anaesthetized by the intravenous infusion of 1 % chloralose (British Drug Houses; 10 ml. = 0-1 g/kg) in sodium chloride solution 0-6 g/100 ml. Subsequently during the experimental procedures a steady state of light anaesthesia was maintained by the infusion every 10 min of either 1 or 0 5 % chloralose, about 1 ml./kg. Each ureter was catheterized through a flank incision into the peritoneal cavity, and urine volume was measured every 10 min collected urine from a urethral catheter). With the animal under positive-pressure ventilation from a Starling 'Ideal' Pump, the chest was opened in the left fifth intercostal space, and a balloon inserted into the left atrium through the appendage in which it was secured by a ligature. The chest was closed, air expelled through a drainage tube in the 7th intercostal space and normal respiration restored. The operative

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“…16 This experiment first led to the hypothesis that the heart has endocrine function and that the natriuresis seen was caused by a yet to be identified hormone secreted by the atrium. In 1984, this hormone was identified as atrial natriuretic factor, later renamed A-type natriuretic peptide (ANP).…”

Section: Physiology Of B-type Natriuretic Peptidementioning

confidence: 99%

B‐type natriuretic peptide measurement in heart failure

Spevack

Schwartzbard

2004

Clinical Cardiology

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SummarySerum testing for the hormone B-type natriuretic peptide (BNP) may have clinical utility in congestive heart failure (CHF). This hormone is secreted predominantly by the left ventricular myocardium in patients with CHF. Measurement of serum BNP may improve diagnosis of CHF and may also help guide therapy in patients with CHF. The literature regarding the clinical utility of BNP measurement in CHF is reviewed.

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The possible role of cardiac atrial stretch receptors in the induction of changes in urine flow

Cited by 224 publications

References 15 publications

Communications

Communications

The mechanisms by which distension of the left atrium produces diuresis in anaesthetized dogs

B‐type natriuretic peptide measurement in heart failure

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