The Possible Role of Electrical Stimulation in Osteoporosis: A Narrative Review

Zhang, Weifei; Luo, Yuanrui; Xu, Jixuan; Guo, Chuan; Shi, Jing; Li, Lü; Sun, Xiao; Kong, Qingquan

doi:10.3390/medicina59010121

Cited by 12 publications

(5 citation statements)

References 76 publications

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“…The use of PEMFs is the treatment method with the greatest evidence of success. However, the specific treatment parameters of frequency and treatment time are not yet conclusive [65].…”

Section: Osteopenia and Osteoporosismentioning

confidence: 99%

Pulsed Electromagnetic Field Stimulation in Bone Healing and Joint Preservation: A Narrative Review of the Literature

Caruso,

Massari,

Lentini

et al. 2024

Applied Sciences

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Background: Biophysical stimulation therapy, Pulsed Electromagnetic Fields (PEMFs) and Capacitively Coupled Electric Fields (CCEFs) have significantly increased in the last twenty years. Due to this, it is necessary to have clear information regarding their efficacy, therapeutic indications and expected objectives. Application fields: There is a unanimous opinion regarding the usefulness of applying biophysical therapy on the bone compartment both in terms of the tissue-healing process and the symptoms associated with this situation. Differently, but no less important, positive results were observed in the joint compartment, especially with regard to the inhibition of the inflammatory process. Good results for chondroprotection were obtained in vitro and after a surgical procedure. New studies have shown the effectiveness also in cases of osteoporosis. Conclusions: The effectiveness of PEMFs and CCEFs on the bone-healing process and on joint preservation in the orthopedic and traumatology fields has consolidated evidence in the literature. We have also found positive results for symptoms and patient compliance with rehabilitation therapies. Therefore, their notable applications can be envisaged in the fields of prosthetic surgery and sports medicine.

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“…The use of PEMFs is the treatment method with the greatest evidence of success. However, the specific treatment parameters of frequency and treatment time are not yet conclusive [65].…”

Section: Osteopenia and Osteoporosismentioning

confidence: 99%

Pulsed Electromagnetic Field Stimulation in Bone Healing and Joint Preservation: A Narrative Review of the Literature

Caruso,

Massari,

Lentini

et al. 2024

Applied Sciences

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“…Another review on electrical stimulation in osteoporosis locates clinical evidence that PEMFs may alleviate osteoporosis-related pain [49], and that bone mass and, thus, osteoporosis could be favorably influenced by PEMF through a RANKL/OPG and Wnt/-catenin pathway. Although the FDA has not yet approved PEMF for the treatment of osteoporosis, based on the current experimental and clinical data, this non-invasive procedure could be an effective adjunct in this indication.…”

Section: Osteopeniamentioning

confidence: 99%

Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment

Flatscher,

Pavez Loriè,

Mittermayr

et al. 2023

IJMS

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Environmental biophysical interactions are recognized to play an essential part in the human biological processes associated with trauma recovery. Many studies over several decades have furthered our understanding of the effects that Pulsed Electromagnetic Fields (PEMF) have on the human body, as well as on cellular and biophysical systems. These investigations have been driven by the observed positive clinical effects of this non-invasive treatment on patients, mainly in orthopedics. Unfortunately, the diversity of the various study setups, with regard to physical parameters, molecular and cellular response, and clinical outcomes, has made it difficult to interpret and evaluate commonalities, which could, in turn, lead to finding an underlying mechanistic understanding of this treatment modality. In this review, we give a birds-eye view of the vast landscape of studies that have been published on PEMF, presenting the reader with a scaffolded summary of relevant literature starting from categorical literature reviews down to individual studies for future research studies and clinical use. We also highlight discrepancies within the many diverse study setups to find common reporting parameters that can lead to a better universal understanding of PEMF effects.

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“…As one of the most common orthopedic diseases, osteoporosis is mainly caused by bone resorption by osteoclasts being greater than bone formation by osteoblasts, resulting in a state of low bone mass, impaired bone tissue microstructure, increased bone fragility, and susceptibility to fracture. Numerous studies have shown that physical electrical stimulation, such as direct current, pulsed current, electric field, and electromagnetic field, can promote bone formation of osteoblasts [28,29], thus providing a certain alleviation and therapeutic effect on osteoporosis, and treatment through electrical stimulation has become a popular research topic.…”

Section: Wound Healing Osteoblast Proliferation and Differentiationmentioning

confidence: 99%

Recent Advance of Triboelectric Nanogenerator-Based Electrical Stimulation in Healthcare

Wang,

Nie

et al. 2023

Electronics

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Along with the continuous aging of the population, various diseases have brought a great threat to human health and a large economic burden. The development of advanced medical devices has gained global attention for disease treatment. Electrical stimulation refers to stimulation and treatment of cells by high output voltage, which is an important rehabilitation and therapeutic strategy in medical treatment. Triboelectric nanogenerators (TENGs), which are lightweight and feature high-voltage output and flexible structure, have drawn great attention in the field of disease treatment for health care. The conversion of the body’s mechanical energy into electrical pulses to stimulate cells for health treatment through TENG has promising applications. Using uniquely designed TENGs to convert human mechanical energy into electrical impulses to stimulate cells is considered a promising health treatment. Here, we review the recent progress of TENG-based electrical stimulation for disease treatments, focusing on the structure, materials, and performances of the TENGs used in diverse facets of healthcare. More importantly, we systematically discuss the application of TENG-based electrical stimulation in wound healing, osteoblast proliferation and differentiation, muscle stimulation, nerve stimulation, and pacemakers. Finally, several developmental challenges of and prospective solutions for TENG-based electrical stimulation are discussed and summarized in light of recent advances.

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The Possible Role of Electrical Stimulation in Osteoporosis: A Narrative Review

Cited by 12 publications

References 76 publications

Pulsed Electromagnetic Field Stimulation in Bone Healing and Joint Preservation: A Narrative Review of the Literature

Pulsed Electromagnetic Field Stimulation in Bone Healing and Joint Preservation: A Narrative Review of the Literature

Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment

Recent Advance of Triboelectric Nanogenerator-Based Electrical Stimulation in Healthcare

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