The Possible Role of Glucose-6-Phosphate Dehydrogenase in the SARS-CoV-2 Infection

Pérez-Torres, Israel; Soto, María Elena; Guarner-Lans, Verónica; Manzano-Pech, Linaloe; Soria-Castro, Elizabeth

doi:10.3390/cells11131982

Cited by 7 publications

(4 citation statements)

References 71 publications

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“…This process is pivotal in anabolism and serves as a metabolic biomarker for viral pathogenesis [55]. However, the role of the pentose phosphate pathway varies with viral species, probably due to their difference in sensitivity to oxidative stress; for example, it promotes influenza virus but inhibits DENV and SARS-CoV-2 viral replications [56][57][58].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic landscape of macrophage discloses an anabolic signature of dengue virus infection and antibody-dependent enhancement of viral infection

Xu,

Li,

Zhang

et al. 2024

PLoS Negl Trop Dis

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Dengue virus (DENV) infection causes dengue fever, the most prevalent arthropod-transmitted viral disease worldwide. Viruses are acellular parasites and obligately rely on host cell machinery for reproduction. Previous studies have indicated metabolomic changes in endothelial cell models and sera of animal models and patients with dengue fever. To probe the immunometabolic mechanism of DENV infection, here, we report the metabolomic landscape of a human macrophage cell model of DENV infection and its antibody-dependent enhancement. DENV infection of THP-1-derived macrophages caused 202 metabolic variants, of which amino acids occupied 23.7%, fatty acids 21.78%, carbohydrates 10.4%, organic acids 13.37%, and carnitines 10.4%. These metabolomic changes indicated an overall anabolic signature, which was characterized by the global exhaustion of amino acids, increases of cellular fatty acids, carbohydrates and pentoses, but decreases of acylcarnitine. Significant activation of metabolic pathways of glycolysis, pentose phosphate, amino acid metabolism, and tricarboxylic acid cycle collectively support the overall anabolism to meet metabolic demands of DENV replication and immune activation by viral infection. Totally 88 of 202 metabolic variants were significantly changed by DENV infection, 36 of which met the statistical standard (P<0.05, VIP>1.5) of differentially expressed metabolites, which were the predominantly decreased variants of acylcarnitine and the increased variants of fatty acids and carbohydrates. Remarkably, 11 differentially expressed metabolites were significantly distinct between DENV only infection and antibody-dependent enhancement of viral infection. Our data suggested that the anabolic activation by DENV infection integrates the viral replication and anti-viral immune activation.

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Section: Discussionmentioning

confidence: 99%

Metabolomic landscape of macrophage discloses an anabolic signature of dengue virus infection and antibody-dependent enhancement of viral infection

Xu,

Li,

Zhang

et al. 2024

PLoS Negl Trop Dis

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“…Although the exact mechanisms are still unknown, a possible association between COVID-19 and G6PD deficiency has been suggested [32] [33] [34]. Risk of hemolysis and thrombosis may be elevated among G6PD-deficient patient infected with COVID-19 [35].…”

Section: Possible Association Between Covid-19 and G6pd Deficiencymentioning

confidence: 99%

G6PD Deficiency and COVID-19 in Burkina Faso: A Possible Link?

Ouattara¹,

Traoré²,

Compaoré³

et al. 2023

JBM

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Burkina Faso is a malaria-endemic country, with a high incidence of G6PD deficiency (G6PDd), which recorded its first case of COVID-19 in March 2020. G6PDd leads to a decrease in the efficiency of erythrocytes to combat oxidative stress, while SARS-CoV-2 infection induces massive production of Reactive Oxygen Species (ROS) in patients. In the present review, we discuss a possible link between G6PDd and SARS-CoV-2 infection. The mean prevalence of G6PDd in Burkina Faso is estimated at 16.6% among males and 6.5% among females. A total of 21,128 cases of COVID-19 have been recorded in Burkina Faso with 387 deaths reported (with a mortality rate of 1.15% among diagnosed cases) as of August 30, 2022. To our knowledge, no association study between G6PDd and SARS-CoV-2 infection has been conducted to date in Burkina Faso. However, several case reports around the world have described elevated risks of hemolysis and thrombosis, and other complications among G6PD-deficient patients infected with SARS-CoV-2. The use of Hydroxychloroquine (HCQ) has also been deemed unsafe by some authors for the treatment of COVID-19 among patients with G6PDd. Although HCQ has been shown to be well tolerated in COVID-19 patients in Burkina Faso, the drug could induce hemolytic crises in people with G6PD deficiency. G6PD is important in regulating ROS and maintaining erythrocyte homeostasis. In view of its high prevalence in Burkina Faso, determination of the G6PD status is required in COVID-19 patients for adequate management such as identifying a subset of COVID-19 patients for whom close monitoring and supportive care may be essential and to restrict treatment with HCQ.

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“…The transformation of Ang II to Ang 1–7, catalyzed by ACE-2, mitigates oxidative stress as it inhibits NADPH oxidase, and therefore, also limits ROS/RNS accumulation ( Kim et al, 2012 ). Interestingly, the ☐-glutamyl-tripeptide glutathione (GSH) is a protagonist of the thiol-dependent antioxidant defenses in mostly all biological systems, and its reduced/oxidized ratio (GSH/GSSG) is fully dependent on NADPH levels and the Pentose Phosphate Pathway activity in cells ( Perez-Torres et al, 2022 ). All these mechanisms shed light on the key participation of the renin-angiotensin-aldosterone system (RAAS) in the redox imbalances associated with viral respiratory diseases ( Morris et al, 2020 ).…”

Section: Potential Mechanisms Involved In Metabolic Modulationmentioning

confidence: 99%

Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2

et al. 2022

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Coronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated with cell damage or tissue injury, but the mechanisms involved are not yet fully elucidated. Some potential mechanisms involved in the COVID-19-induced tissue dysfunction are proposed, such as: (a) High expression and levels of proinflammatory cytokines, including TNF-α IL-6, IL-1β, INF-α and INF-β, increasing the systemic and tissue inflammatory state; (b) Induction of oxidative stress due to redox imbalance, resulting in cell injury or death induced by elevated production of reactive oxygen species; and (c) Deregulation of the renin-angiotensin-aldosterone system, exacerbating the inflammatory and oxidative stress responses. In this review, we discuss the main metabolic disturbances observed in different target tissues of SARS-CoV-2 and the potential mechanisms involved in these changes associated with the tissue dysfunction.

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The Possible Role of Glucose-6-Phosphate Dehydrogenase in the SARS-CoV-2 Infection

Cited by 7 publications

References 71 publications

Metabolomic landscape of macrophage discloses an anabolic signature of dengue virus infection and antibody-dependent enhancement of viral infection

Metabolomic landscape of macrophage discloses an anabolic signature of dengue virus infection and antibody-dependent enhancement of viral infection

G6PD Deficiency and COVID-19 in Burkina Faso: A Possible Link?

Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2

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