THE POSSIBLE ROLE OF <i>SHIGELLA</i> IN SPORADIC ENTERIC REACTIVE ARTHRITIS

Sieper, J.; Braun, Jürgen; Wu, Peng; Hauer, R.-W.; Laitko, S

doi:10.1093/rheumatology/32.7.582

Cited by 21 publications

(8 citation statements)

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“…Forms of ReA where bacteria have been shown to play a role include pathologic entities in association with Campylobacter (9), Salmonella (10), Chlamydia (11), Shigella (12) infections, Lyme disease (13) and Reiter 's syndrome (14).…”

Section: The Reactive Nature Of Acute Rheumatic Fever: Evidence From mentioning

confidence: 99%

The Reactive Nature of Acute Rheumatic Fever: Evidence From Streptococcal Cell Wall Antigen Detection by Immunotechnology

et al. 2008

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and Clinical Pathology 2 , EgyptAim: The life-threatening group A streptococcal (strep) infection and its sequelae, including acute rheumatic fever (ARF), re-emerged as a serious health problem. The fleeting arthritis of ARF is considered a form of reactive arthritis. However, no one has confirmed this by investigating its synovial fluid cells for a possible presence of strep cell wall antigens using western blot in humans. This is the aim of the current study.Methods: Synovial fluid-(SF) and peripheral blood-mononuclear cells (PB-MNCs) from 40 patients with ARF and 10 patients with rheumatoid arthritis (RA), who served as a control group, were examined for strep antigens by immunofluorescence (IF) and western blot (WB) techniques using rabbit polyclonal antiserum and mouse monoclonal antibodies.Results: Extensive bacterial cultures of SF, blood and throat were negative. By IF, a significant proportion (37.5%) of ARF samples (Chi-square=3.72, p=0.048) showed positive staining in SF-as well as PB-MNCs with both rabbit polyclonal antiserum and mouse monoclonal antibodies. Further, IF was significantly higher in ARF-than RA-patients (Mann-Whitney p=0.022) in whom we failed to observe any staining. By immunoblotting, 21 samples from ARF patients (52.2%) were positive with mouse monoclonal antibodies specific for strep peptideglycan-polysaccharide (PG-PS) complex in SF-Cs (a band with a molecular weight of 28 kD) and PB-MNCs (29kD) and its proportion was significant (p=0.0008). With rabbit polyclonal antiserum, significant blots (p=0.027) were noted in 27/40 ARF patients (67.5%) indicating strep PG-PS (24-29kD broad band) in SF-Cs and PB-MNCs. Blots by both monoand poly-clonal antibodies were significantly higher (p=0.003&=0.001, respectively) than control samples that were non-reactive using both types of antibodies. Conclusion:The reactive nature of acute rheumatic fever is suggested by the frequent detection of streptococcal cell wall antigen from affected joints using both, immunofluorescence and western blotting.

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Section: The Reactive Nature Of Acute Rheumatic Fever: Evidence From mentioning

confidence: 99%

The Reactive Nature of Acute Rheumatic Fever: Evidence From Streptococcal Cell Wall Antigen Detection by Immunotechnology

et al. 2008

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“…Furthermore, synovial uid T cells from reactive arthritis patients proliferate speci®cally when stimulated with salmonella antigens [18], whereas peripheral blood T-cell responses appear to be decreased [24]. Other studies have shown that LPS from Sh.¯exneri can be detected in synovial samples from patients with reactive arthritis [25] and synovial¯uid T-cell responses to shigella have also been observed in patients with reactive arthritis [26].…”

Section: Ankylosing Spondylitismentioning

confidence: 99%

HLA molecules, bacteria and autoimmunity

Ebringer

Wilson²

2000

Journal of Medical Microbiology

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“…The presence of HLA-B27 may influence the clinical course of ReA (91), but this is not always the case (86,88). B27 was found less frequently to be positive in enterogenic ReA after Salmonella infections (0-33%) (88,92,93) than after Yersinia, Campylobacter, or Shigella infections (85,94,95). Although bias may occur in the selection of infected individuals, HLA-B27-positive individuals with more severe disease are more easily referred for further evaluation (96)-It seems likely that a genuine difference exists with regard to an HLA-B27 association in patients infected with Salmonella or Shigella (97).…”

Section: "Enterogenic Reactive Arthritis"mentioning

confidence: 99%

Spondyloarthropathy and idiopathic inflammatory bowel diseases

Crusius¹,

Peña²,

Dekker-Saeys³

et al. 1997

Inflamm Bowel Dis

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: Spondyloarthropathy (SpA) as observed in patients with idiopathic inflammatory bowel diseases is categorized according to the recently developed criteria of the European Spondylarthropathy Group, and belongs to a large complex of rheumatic disorders, encompassing ankylosing spondylitis, Reiter's disease, psoriatic arthritis, and reactive arthritis. It has been recognized for many years that patients with ulcerative colitis or Crohn's disease frequently have arthritic complications. The gastroenterologist should therefore carefully evaluate any symptom of peripheral or axial arthritis, in an attempt to provide an accurate diagnosis, to define a realistic prognosis, and to establish adequate therapy at an early stage. In this review, clinical and etiopathogenic aspects are analyzed, not only of patients with inflammatory bowel diseases and SpA, but also of patients developing arthritic symptoms after gastrointestinal bacterial infections (reactive arthritis). The significance of ileal mucosal inflammation as observed frequently in patients with SpA is discussed; the contribution of immunogenetic factors in the development of SpA, such as HLA-B27, is briefly reviewed. Finally, analysis is made of the different therapeutic options that are available at present.

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THE POSSIBLE ROLE OF SHIGELLA IN SPORADIC ENTERIC REACTIVE ARTHRITIS

Cited by 21 publications

References 0 publications

The Reactive Nature of Acute Rheumatic Fever: Evidence From Streptococcal Cell Wall Antigen Detection by Immunotechnology

The Reactive Nature of Acute Rheumatic Fever: Evidence From Streptococcal Cell Wall Antigen Detection by Immunotechnology

HLA molecules, bacteria and autoimmunity

Spondyloarthropathy and idiopathic inflammatory bowel diseases

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