The possible role of milk thistle extract on titanium dioxide nanoparticles-induced lung toxicity in male albino rat

Elhaliem, Nesreen G. Abd

doi:10.1097/01.ehx.0000490004.09559.3a

“…Previous researchers [47][48][49][50][51] found similar changes in lung tissues in their studies and attributed these changes to free radicals produced by TiO2-Nps, which exert a strong oxidizing abilityand produce epithelial injury and oxidative stress in rodents.…”

Section: Discussionmentioning

confidence: 61%

“…In addition TiO2-Nps injected group showed blood vessels injuries and hemorrhage that appeared in alveoli wall and alveolar space. Previous researches [18,51] supposed that ROS could attach to the endothelial cells of vessel wall causing their damage and increase blood air barrier permeability, lead to extravasation into the septa.…”

Section: Discussionmentioning

confidence: 99%

CEffect of Silver Nanoparticles Versus Titanium Dioxide Nanoparticles on the Lung of Adult Male Albino Rats: A histological and immunohistochemical study

Gawish

¹

,

Shaban

²

,

Aal

³

et al. 2019

Journal of Medical Histology

2

0

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Background: Silver nanoparticles (Ag-Nps) and Titanium dioxide nanoparticles (TiO2-Nps) are well-known nanoproducts. Both of them have many industrial applications. Lung is one of the major target organs for prolonged nanoparticles exposure. Objective: This study was designed to investigate and compare the possible histopathological toxic effect of Ag-Nps & TiO2-Nps on lung and which of them is safer for future using. Materials & methods: 54 adult male albino rats were divided into 3 equal groups; GroupI (control group), Group II that subdivided into two subgroups; Subgroup IIa: Ag-Nps group with (100 mg/kg/day) daily for 4 successive weeks and Subgroup IIb recovery group left for 4 weeks without injection, Group III that subdivided into two subgroups; Subgroup IIIa: TiO2-Nps group with (150 mg/kg/day) for 4 successive weeks and Subgroup IIIb recovery group left for 4 weeks without injection. Lung specimens were processed for light and electron microscope and immunohistochemical expression of caspase-3 and CD-68. Morphometric and statistical analysis were performed. Results: Group IIa showed collapsed alveoli, others showed ballooned distension and marked thickening of inter-alveolar septa. Extensive cellular infiltration was detected. Group IIIa showed focal areas of collapsed alveoli and thick inter-alveolar septa. Mild cellular infiltrations were observed. Areas of extravasation were detected in the interstitium. Group IIIb showed signs of improvement which is more than group IIb. Conclusion: exposure to Ag-Nps showed marked alterations on histological structure of lung, which is more than the alteration caused by TiO2-Nps; in addition, recovery period was proved to ameliorate these changes better in TiO2-Nps.

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“…Many reports have indicated that when the size of the nanoparticles is low, their ability to destroy the cancer cells is greater. In detail, it has been reported that nanoparticles with a size lower than 50 nm have the best condition for anticancer effects [13][14][15][16][17][18]. As shown in the FE-SEM figure, the size of nanoparticles is less than 40 nm.…”

Section: Anti-human Breast Carcinoma Effects Of the Titanium Nanoparticlesmentioning

confidence: 99%

“…TiNPs have exhibited optical, dielectric, and photo-catalytic properties. TiNPs also show biological activ-ity such as anticancer, antibacterial, and antifungal activity [13][14][15][16][17]. These properties depend on various factors such as surface area, morphology, crystallinity, and crystal phase effect on the operational performance of TiNPs [18].…”

Section: Introductionmentioning

confidence: 99%

Novel Alhagi maurorum leaves mediated synthesis of titanium nanoparticles for human breast carcinoma applications: a preclinical trial study

Ye

¹

,

Shi

²

,

Zhang

³

et al. 2021

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IntroductionIn this study, titanium nanoparticles (TiNPs) were synthesized in an aqueous medium using Alhagi maurorum extract as stabilizing and reducing agents.Material and methodsUltraviolet–visible spectrophotometry (UV-Vis), fourier-transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), and Energy Dispersive X-ray Spectrometry (EDS) were the techniques to characterize the biosynthetic of TiNPs. According to the XRD analysis. To survey the anti-human breast cancer effects of TiNPs, MTT assay was used on the common breast cancer cell lines i.e., breast cancer (Breast adenocarcinoma (MCF7), infiltrating ductal cell carcinoma (Hs 319.T), inflammatory carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453) cell lines.Results16.08 nm was measured for TiNPs crystal size. SEM images exhibited a uniform spherical morphology in range size of 12.16 to 43.46 nm for the biosynthesized nanoparticles respectively. The cell viability of breast carcinoma cells decreased dose-dependently in the titanium nanoparticles presence. The IC50 of A. maurorum and titanium particles on MCF7 cell line were 680 and 359 µg/mL, on Hs 319.T cell line were 507 and 191 µg/mL, on UACC-732 cell line were 477 and 217 µg/mL, and on MDA-MB-453cell line were 507 and 191 µg/mL, respectively. TiNPs had high anti-breast cancer activities dose-dependently against MCF7, Hs 319.T, UACC-732, and MDA-MB-453 cell lines.ConclusionsThe best result of anti-breast cancer effects was seen in the case of the Hs 319.T cell line.

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“…TiNPs have exhibited optical, dielectric, photo-catalytic properties. TiNPs also show biological activity such as anticancer, antibacterial, and antifungal activity [9][10][11][12][13] . These properties depend on different factors such as surface area, morphology, crystallinity, and crystal phase effect on the operational performance of TiNPs 14 .…”

Section: P R E P R I N Tmentioning

confidence: 99%

Novel Alhagi maurorum leaves mediated synthesis of titanium nanoparticles for human breast carcinoma applications: a preclinical trial

Ye

¹

,

Shi

²

,

Zhang

³

et al. 2021

Arch Med Sci

1

0

View full text Add to dashboard Cite

IntroductionIn this study, titanium nanoparticles (TiNPs) were synthesized in an aqueous medium using Alhagi maurorum extract as stabilizing and reducing agents.Material and methodsUltraviolet–visible spectrophotometry (UV-Vis), fourier-transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), and Energy Dispersive X-ray Spectrometry (EDS) were the techniques to characterize the biosynthetic of TiNPs. According to the XRD analysis. To survey the anti-human breast cancer effects of TiNPs, MTT assay was used on the common breast cancer cell lines i.e., breast cancer (Breast adenocarcinoma (MCF7), infiltrating ductal cell carcinoma (Hs 319.T), inflammatory carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453) cell lines.Results16.08 nm was measured for TiNPs crystal size. SEM images exhibited a uniform spherical morphology in range size of 12.16 to 43.46 nm for the biosynthesized nanoparticles respectively. The cell viability of breast carcinoma cells decreased dose-dependently in the titanium nanoparticles presence. The IC50 of A. maurorum and titanium particles on MCF7 cell line were 680 and 359 µg/mL, on Hs 319.T cell line were 507 and 191 µg/mL, on UACC-732 cell line were 477 and 217 µg/mL, and on MDA-MB-453cell line were 507 and 191 µg/mL, respectively. TiNPs had high anti-breast cancer activities dose-dependently against MCF7, Hs 319.T, UACC-732, and MDA-MB-453 cell lines.ConclusionsThe best result of anti-breast cancer effects was seen in the case of the Hs 319.T cell line.

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The possible role of milk thistle extract on titanium dioxide nanoparticles-induced lung toxicity in male albino rat

Cited by 4 publications

References 42 publications

CEffect of Silver Nanoparticles Versus Titanium Dioxide Nanoparticles on the Lung of Adult Male Albino Rats: A histological and immunohistochemical study

CEffect of Silver Nanoparticles Versus Titanium Dioxide Nanoparticles on the Lung of Adult Male Albino Rats: A histological and immunohistochemical study

Novel Alhagi maurorum leaves mediated synthesis of titanium nanoparticles for human breast carcinoma applications: a preclinical trial study

Novel Alhagi maurorum leaves mediated synthesis of titanium nanoparticles for human breast carcinoma applications: a preclinical trial

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