The possible role of the seaweed<i>Sargassum vulgare</i>as a promising functional food ingredient minimizing aspartame-associated toxicity in rats

Ibrahim, Rasha Youssef Mohammed; Hammad, Huda Badr Ibrahim; Gaafar, Alaa A.; Saber, Abdullah A.

doi:10.1080/09603123.2020.1797642

Cited by 14 publications

(6 citation statements)

References 77 publications

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“…Our result for S. vulgare is comparable to that of the aqueous extract (27.15 mg GAE/g dry extract) of Sargassum siliquastrum (Cho et al, 2007). However, the TPC determined for S. vulgare is higher than the results noted for the same species harvested in the Red Sea, Egypt (4.99 ± 0.26 mg GAE/g dry extract) (Ibrahim et al, 2020). The author pointed out that the phenolic content of algae within the same species varies considerably from one study to another and depends on a wide variety of biotic and abiotic factors, including the condition of the specimens studied and the extraction solvent used.…”

Section: Total Phynolic Contentsupporting

confidence: 61%

“…This variation in total phenolic content could be attributed to differences in the polarity of the extraction solvents used. Ibrahim et al (2020) reported that the polar solvent "methanol" was more efficient than water and other non-polar solvents for extracting polyphenols. Furthermore, the phenolic compound amounts obtained in this study for C. amentacea and C. sedoides are lower than those of C. Barbata (Trifan et al, 2019).…”

Section: Total Phynolic Contentmentioning

confidence: 99%

“…Whereas, this result is in agreement with our data for C. amentacea. Climatic and environmental conditions could be at the origin of the fluctuation in flavonoid content in algae (Ibrahim et al, 2020).…”

Section: Total Flavonoid Contentmentioning

confidence: 99%

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Biochemical Composition and Toxicity Assessment of Seaweeds from the Algerian Coast: Implications for Human Consumption and Marine Pollution

Ousmer,

Madani,

Dahim

et al. 2024

Preprint

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Seaweeds are widely used as food and natural remedies among the Asian population. In this study, the biochemical composition of Cystoseeira amentacea, Cystoseira sedoides, and Sargassum vulgare from the Algerian coast was evaluated. The results indicated that the protein content ranged from 8.62–9.56%, whereas the lipid content varied from 0.77 to 2.35%. The most prevalent unsaturated fatty acid was oleic acid (14.47–18.64%). The seaweeds contain phenolic compounds in varying amounts, LC-MS-MS analysis showed the presence of catechin, p-coumaric acid, caffeic acid, and gallic acid. Moreover, the phaeophyta are rich in potassium and calcium. However, they accumulate high quantities of heavy metals including arsenic (403.92 ± 1.299 to 508.62 ± 1.364 mg/100g of dry matter). The results suggest that these algae are rich in primary and secondary metabolites, however, they cannot serve as human food, due to their toxicity. Consequently, they can used as bioindicators of marine pollution. Keyworlds : Seaweeds, Phenolic compounds, Fatty acids, Proteins, Flavonoids, Heavy metals.

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Section: Total Phynolic Contentsupporting

confidence: 61%

Section: Total Phynolic Contentmentioning

confidence: 99%

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Biochemical Composition and Toxicity Assessment of Seaweeds from the Algerian Coast: Implications for Human Consumption and Marine Pollution

Ousmer,

Madani,

Dahim

et al. 2024

Preprint

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“…Thallus ditutupi oleh cabang-cabang duri yang berasal dari cabang utama (Tarigan, 2020). Sargassum vulgare memiliki komponen bioaktif yang bertindak sebagai aktivitas antioksidan dan antivirus terhadap sulfoquinovosyldiacylglycerols (Khaled et al, 2012;Plouguerné et al, 2013;Ibrahim et al, 2022). Selanjutnya, Ibrahim et al (2022)…”

Section: Sargassum Vulgareunclassified

Identifikasi Makroalga yang Tersebar di Perairan Walakiri Sumba Timur

Meiyasa,

Rutung,

Amah

et al. 2023

J-Pendidikan Biologi

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This study aims to identify macroalgae scattered in Walakiri waters. The method used in this study was to explore the entire coast of Walakiri. The samples which were then identified visually and morphologically include: color, thallus shape, serrations on the stems of each macroalgae sample and then matched to AlgaeBase: http://www.algaebase.org. The results showed that there were 3 classes of macroalgae with a total of 10 species including red algae (Eucheuma cottonii, Eucheuma spinosum, Achanthopora spicifera), brown algae (Padina australis, Sargassum vulgare, Sargassum cristaefolium, Sargassum polycystum), and green algae (Ulva reticulata, Halimeda micronesica, Codium Fragile). In addition, the water quality of Walakiri is good for macroalgae growth.

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“…Seaweeds, also known as marine macroalgae, have been recently used in several industrial and pharmaceutical applications, such as novel food supplements (e.g., Alam et al 2016 ; Al Adham et al 2017 ; Leandro et al 2020 ; Ibrahim et al 2021 , 2022 ) as they contain abundant multifunctional bioactive compounds such as polysaccharides, carotenoids, polyphenolics, antioxidants, dietary fibers, polyunsaturated fatty acids, vitamins, and minerals (Devi et al 2011 ; Pereira 2020 ; Pradhan et al 2021 ; Semaida et al 2022 ). Several structurally diverse polysaccharides, such as alginates and fucoidan, found within the cell walls of brown seaweeds, are exploited for their powerful pharmaceutical and biomedical properties (Rashad and El-Chaghaby 2020 ; Rashedy et al 2021 ; Saeed et al 2021 ; Ismail et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin in rats

Samir

Hassan

Saber

et al. 2023

Environ Sci Pollut Res

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Doxorubicin (DOX) is a potent anticancer drug with adverse cardiotoxic effects. Alginates are multifunctional biopolymers and polyelectrolytes derived from the cell walls of brown seaweeds. They are nontoxic, biocompatible, and biodegradable, and hence, utilized in several biomedical and pharmaceutical applications. Here, we investigated the potential cardioprotective effect of thermally treated sodium alginate (TTSA), which was extracted and purified from the seaweed Sargassum aquifolium, in treating acute DOX cardiotoxicity and apoptotic pathways in rats. UV–visible spectroscopy, Fourier-transform infrared, and nuclear magnetic resonance (1H–NMR) spectroscopy techniques were used to characterize TTSA. CK-MB and AST levels in sera samples were determined. The expression levels of Erk-2 (MAPK-1) and iNOS genes were investigated by quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression levels of Erk-2, anti-apoptotic p53, and caspase-3 were analyzed using western blotting and ELISA. For the in vivo studies, sixty rats were randomly divided equally into six groups and treated with DOX, followed by TTSA. We revealed that treatment with TTSA, which has low molecular weight and enhanced antioxidant properties, improved DOX-mediated cardiac dysfunction and alleviated DOX-induced myocardial apoptosis. Furthermore, TTSA exhibited a cardioprotective effect against DOX-induced cardiac toxicity, indicated by the increased expression of MAPK-1 (Erk2) and iNOS genes, which are implicated in the adaptive responses regulating DOX-induced myocardial damage. Moreover, TTSA significantly (p < 0.05) suppressed caspase-3 and upregulated anti-apoptotic protein p53 expression. TTSA also rebalanced the cardiomyocyte redox potential by significantly (p < 0.05) increasing the levels of endogenous antioxidant enzymes, including catalase and superoxide dismutase. Our findings suggest that TTSA, particularly at a dose of 400 mg/kg b.w., is a potential prophylactic supplement for treating acute DOX-linked cardiotoxicity.

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The possible role of the seaweedSargassum vulgareas a promising functional food ingredient minimizing aspartame-associated toxicity in rats

Cited by 14 publications

References 77 publications

Biochemical Composition and Toxicity Assessment of Seaweeds from the Algerian Coast: Implications for Human Consumption and Marine Pollution

Biochemical Composition and Toxicity Assessment of Seaweeds from the Algerian Coast: Implications for Human Consumption and Marine Pollution

Identifikasi Makroalga yang Tersebar di Perairan Walakiri Sumba Timur

Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin in rats

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