The possible role of virus-specific CD8 + memory T cells in decidual tissue

Egmond, Angela van; Keur, Carin van der; Swings, Godelieve M.J.S.; Scherjon, Sicco A.; Claas, Frans H.J.

doi:10.1016/j.jri.2015.09.073

Cited by 55 publications

(48 citation statements)

References 46 publications

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“…Seropositive women during late pregnancy demonstrated an accumulation of highly differentiated HCMV-specific T-cells (139). Moreover, increased percentages of HCMV and EBV-specific CD8 + T cells were also found in decidual tissue compared with peripheral blood after uncomplicated pregnancy (142). These decidual virus-specific CD8 + memory T cells were able to produce IFNγ and were restricted to recognize viral peptides presented by HLA-A or HLA-B molecules.…”

Section: Hla-c-restricted Pathogen-specific Cd8 + T Cell Responsesmentioning

confidence: 99%

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

et al. 2019

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Section: Hla-c-restricted Pathogen-specific Cd8 + T Cell Responsesmentioning

confidence: 99%

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

et al. 2019

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“…Besides the studies of virus-specific CD8+ T cells in maternal blood, a recent study demonstrated increased percentages of HCMV and Epstein Bar virus (EBV)-specific CD8+ T cells in decidual tissue compared with peripheral blood after uncomplicated pregnancy. These virus-specific CD8+ memory T cells were able to produce IFNγ and were restricted to recognize viral peptides in HLA-A or HLA-B molecules (van Egmond et al, 2016). Thus, these CD8+ dT may provide cellular immunity for infected maternal cells that express HLA-A and HLA-B.…”

Section: Anti-viral and Bacterial Immunity By Cd8 T Cells In Pregnancymentioning

confidence: 99%

Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections

Crespo

Zwan

Ramalho‐Santos

et al. 2017

Journal of Reproductive Immunology

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To establish a healthy pregnancy the maternal immune system must tolerate fetal allo-antigens, yet remain competent to respond to infections. The ability of decidual NK cells (dNK) to promote migration of fetal extravillous trophoblasts (EVT) and placental growth as well as the capacity of EVT to promote immune tolerance are topics of high interest and extensive research. However, the problem of how dNK and decidual CD8+ T cells (CD8+ dT) provide immunity to infections of the placenta and the mechanisms that regulate their cytolytic function has thus far largely been ignored. Fetal EVT are the most invasive cells of the placenta and directly interact with maternal decidual immune cells at this maternal-fetal interface. Besides the expression of non-polymorphic HLA-E and HLA-G molecules that are associated with immune tolerance, EVT also express highly polymorphic HLA-C molecules that can serve as targets for maternal dNK and CD8+ dT responses. HLA-C expression by EVT has a dual role as the main molecule to which immune tolerance needs to be established and as the only molecule that can present pathogen-derived peptides and provide protective immunity when EVT are infected. The focus of this review is to address the regulation of cytotoxicity of dNK and CD8+ dT, which is essential for maternal-fetal immune tolerance as well as recent evidence that both cell types can provide immunity to infections at the maternal-fetal interface. A particular emphasis is given to the role of HLA-C expressed by EVT and its capacity to elicit dNK and CD8+ dT responses.

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“…In vitro studies have shown that trophoblasts produce a wide variety of anti-microbial substances 5, 10 and decidual NK cells are able to control cytomegalovirus (CMV) infections 11 . It has also been shown that memory CD8 + T cells specific for CMV and Epstein-Barr virus accumulate in decidual tissues 12 .…”

Section: Introductionmentioning

confidence: 99%

MAIT cells accumulate in placental intervillous space and display a highly cytotoxic phenotype upon bacterial stimulation

Solders

Gorchs

Erkers

et al. 2017

Sci Rep

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During pregnancy, the maternal immune system must tolerate the developing foetus, and yet retain a potent antimicrobial response to prevent infections. Mucosal associated invariant T (MAIT) cells recognize microbial-derived vitamin B metabolites presented on the MR1 molecule, but their presence and function at the foetal-maternal interface is not known. We here isolated mononuclear cells from paired samples of peripheral blood (PB), intervillous blood (IVB), and decidua parietalis (DP) following uncomplicated term pregnancies. Interestingly, MAIT cells were highly enriched in IVB compared to PB and DP. The activation status of IVB MAIT cells was similar to that of PB MAIT cells, except for a lower expression of PD-1. Both IVB MAIT cells and conventional T cells were more dominated by an effector memory phenotype compared to PB MAIT cells and T cells. IVB MAIT cells also responded more vigorously with expression of IFN-γ, granzyme B, and perforin in response to Escherichia coli stimulation compared to PB. MR1 was not expressed in syncytiotrophoblasts, but in placental villous and decidual macrophages. These data indicate that maternal MAIT cells accumulate in the intervillous space of the placenta and that they are highly armed to quickly respond if bacteria are encountered at the foetal-maternal interface.

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The possible role of virus-specific CD8 + memory T cells in decidual tissue

Cited by 55 publications

References 46 publications

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections

MAIT cells accumulate in placental intervillous space and display a highly cytotoxic phenotype upon bacterial stimulation

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