The possible significance of hexosephosphoric esters in ossification

Robison, Robert; Soames, Katharine Marjorie

doi:10.1042/bj0241922

Cited by 54 publications

(45 citation statements)

References 5 publications

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“…The association of alkaline phosphatase wi th the pro cess of calcification in cartilage and bona has been confirmed by numerous workers since Robison (1923) first suggested it. It was shown that alkaline phosphatase was not present in cartilage which was not ossifying, but that at the stage of ossification which is represented by hypertrophy of the cells, the enzyme appeared.…”

mentioning

confidence: 77%

A histological and histochemical study of the development of the sternum in thalidomidetreated rats

Globus

Gibson

1968

Teratology

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The development of the sternum was studied in normal and thalidomide‐treated rat embryos and fetuses. Morphologically, the sternal abnormalities included: crowding of the sternocostal articulations, absence of sternebrae, “scrambled” sternebrae, paired sternebrae, torsion of the sternum, partially cleft sternums, and completely bifurcated sternums. These malformations were related to an abnormal rib pattern and to a delayed growth rate of the ribs and sternebral primordia. Histochemically, the distribution and relative amounts of glycogen, alkaline phosphatase, calcium, and ribonucleic acid were studied. In cartilage the degradation of glycogen and the activity of alkaline phosphatase were influenced by thalidomide. This resulted in increased storage of glycogen and a reduction or absence of alkaline phosphatase activity. These changes were reflected in the rate of deposition of the cartilage matrix, and were most notable at the hypertrophic cartilage stage. Calcification of the cartilage was delayed, indicating the retardation in matrix deposition. No changes were observed in the staining pattern of ribonucleic acid. The deposition and calcification of endochondral bone was delayed, possibly caused by the delay in chondrification rather than by a direct effect on the ossification mechanism. No changes were observed in the development of the intramembranous, subperiosteal bone.

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mentioning

confidence: 77%

A histological and histochemical study of the development of the sternum in thalidomidetreated rats

Globus

Gibson

1968

Teratology

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“…Earlier work indicated the importance in the matrix of alkaline phosphatase (Robison, 1932), collagen fibres (Glimcher & Krane, 1968), phospholipids (Irving & Wuthier, 1968) and protein-polysaccharides (Bowness, 1968), but there is as yet no unified concept that relates all these diverse participants in the mineralization process.…”

mentioning

confidence: 99%

The uptake of [45Ca]calcium ions by matrix vesicles isolated from calcifying cartilage (Short Communication)

Ali

Evans

1973

Biochemical Journal

136

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“…Paget's Disease, (4) Rickets, (5) Mult-iple Myeloma, (6) Jaundice due to Liver Metastases known (13). The phosphatase activity of involved bone in a case of multiple myeloma (Case 5) was within normal limits.…”

Section: Osteolytic Bone Metastases (3)mentioning

confidence: 96%

“…The role of bone phosphatase in the mechanism of normal bone formation, as elucidated by Robison and his collaborators (18), may be outlined as follows: the intercellular fluids bathing osteogenic cells contain salts of phosphoric esters, which are hydrolyzed by the phosphatase elaborated by those cells. In this manner, the concentration of phosphate ions is increased locally to a point exceeding the solubility product of calcium phosphate and of the related compounds composing bone.…”

Section: Relation Of Local Increases In Bone Phosphatase Activity To mentioning

confidence: 99%

Significance of Increased Phosphatase Activity of Bone at the Site of Osteoplastic Metastases Secondary to Carcinoma of the Prostate Gland

Gutman¹,

Sproul²,

Gutman³

1936

The American Journal of Cancer

305

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The possible significance of hexosephosphoric esters in ossification

Cited by 54 publications

References 5 publications

A histological and histochemical study of the development of the sternum in thalidomidetreated rats

A histological and histochemical study of the development of the sternum in thalidomidetreated rats

The uptake of [45Ca]calcium ions by matrix vesicles isolated from calcifying cartilage (Short Communication)

Significance of Increased Phosphatase Activity of Bone at the Site of Osteoplastic Metastases Secondary to Carcinoma of the Prostate Gland

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