The possible therapeutic role of ginger extract in the effect of chronic aluminum toxicity on rat periodontium (Histological and Immunohistochemical study)

Saad, Fatma Adel

doi:10.21608/ejh.2019.18936.1192

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…This could be attributed to the anti-inflammatory effect of both materials on the PDL, as established by Mortazavi and Baharvand [24] and Siddiqui et al [25]. Moreover, ginger has an antiosteoclastogenic effect that prevents bone resorption in periodontitis, as confirmed by Saad [26] and Kim et al [27]. They suggested the potential use of ginger as an antiresorptive strategy in periodontitis.…”

Section: Discussionmentioning

confidence: 83%

Effectiveness of Calcium Hydroxide and Gingerols Mixture as a Novel Obturation Material for Infected Root in Primary Teeth: A Randomized Clinical Trial

Qasem,

Awad,

Elagamy

2024

International Journal of Dentistry

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Introduction. The tendency to use dental materials of plant origin is one of the prevailing trends in dentistry to reduce exposure to materials that could have some toxic impact in the long term. Objective. To evaluate the efficacy of calcium hydroxide combined with gingerols (Ginge-Cal) as a novel obturation material for treating infected primary teeth and decreasing the recurrence of infection. Materials and Methods. The study was conducted on 30 lower primary molars with infected pulp for children aged 4–8 years. The sample was randomly divided into two groups depending on the tested obturation material: Ginge-Cal group and the Metapex group. The evaluation was done by different parameters clinically and radiographically at various intervals up to 12 months. Results. Based on chi-squared and McNamara’s test with a 5% significance level, the clinical results indicated that Ginge-Cal group was more effective than the Metapex group in reducing or eliminating pain (P=0.467) after 1 week, sensitivity to percussion (P=0.090) at 3 months of follow-up, purulent swelling (P=0.444) at 6 and 9 months of follow-up, fistula, and tooth mobility. The radiographic results, based on the periapical and furcation area radiolucency at 12 months of follow-up, favored Ginge-Cal group over the Metapex group (P=0.683), (P=0.456), respectively. There were no statistically significant differences in pathological root resorption and periodontal space. The differences within the Ginge-Cal group were directly influenced by the time intervals in a statistically significant manner, ranging from (P=0.004) to (P<0.001). The success percentage was 87.5% for Ginge-Cal group and 64.3% for Metapex group. Conclusions. Ginge-Cal can be considered a promising material for treating the infected root canal when used as an obturation material for the infected root canal. This trial is registered with NCT05181813.

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Section: Discussionmentioning

confidence: 83%

Effectiveness of Calcium Hydroxide and Gingerols Mixture as a Novel Obturation Material for Infected Root in Primary Teeth: A Randomized Clinical Trial

Qasem,

Awad,

Elagamy

2024

International Journal of Dentistry

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“…(2020) suggested that galangin, which is present in ginger, decreases the inflammatory response and the rate of apoptosis. Saad (2019) found that rats treated with 150 mg kg −1 day −1 of ginger oil extract orally for 4 weeks, after receiving 20 mg kg −1 day −1 of aluminum chloride, showed a significant decrease in the number of CD68‐positive cells in the periodontal ligament.…”

Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory activity of ginger modulates macrophage activation against the inflammatory pathway of monosodium glutamate

et al. 2021

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Monosodium glutamate (MSG) has been traditionally used as a flavor enhancer and is added to many foods. The chronic consumption of MSG has been suggested as causing toxicity, inflammation, obesity, type 2 diabetes, and pre‐malignant changes. The use of medicinal plants and their products, such as ginger, against the effects of MSG has been suggested to have a protective effect. To evaluate the anti‐inflammatory activity of ginger against the effects of MSG, we conducted a serial inflammatory analysis of MSG‐ and ginger‐treated rats, focusing particularly on liver pathology. The consumption of ginger as an unconventional therapy against the effects of MSG resulted in significant anti‐inflammatory activity. We found that it was possible to diagnose MSG‐associated inflammatory pathogenesis using inflammatory mediators. Ginger consumption produced protective effects on health, minimized adverse effects, and may be applicable for food development and the treatment of many inflammatory diseases. Practical applications The chronic administration of monosodium glutamate (MSG) as a flavor enhancer has been suggested to produce toxicity, inflammation, and pre‐malignant changes in organs. Ginger has protective effects, with potent anti‐inflammatory and anti‐fibrotic activity against MSG administration. This study is the first to report that ginger modulated the inflammatory and fibrotic effects of MSG and improved immunological indices reflecting the involvement of inflammatory and fibrotic markers and polysaccharide content in the activation of macrophages. These findings support the further use of ginger as a supplement for food enhancement and as an anti‐fibrotic, anti‐inflammatory, and therapeutic agent in pharmaceutical therapies against autoimmune and inflammatory diseases, such as rheumatoid arthritis, lupus, and ulcerative colitis, as well as MSG‐associated inflammatory diseases.

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The possible therapeutic role of ginger extract in the effect of chronic aluminum toxicity on rat periodontium (Histological and Immunohistochemical study)

Cited by 2 publications

References 33 publications

Effectiveness of Calcium Hydroxide and Gingerols Mixture as a Novel Obturation Material for Infected Root in Primary Teeth: A Randomized Clinical Trial

Effectiveness of Calcium Hydroxide and Gingerols Mixture as a Novel Obturation Material for Infected Root in Primary Teeth: A Randomized Clinical Trial

Anti‐inflammatory activity of ginger modulates macrophage activation against the inflammatory pathway of monosodium glutamate

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