The Possible Ultra Structural Ameliorative Effect of Taurine in Rat`s Liver Treated with Monosodium Glutamate (MSG)~!2009-06-12~!2009-11-22~!2010-05-04~!

El-Agouza, Ibrahim M. A.; Nashar, Dalia E. El; Eissa, Saad

doi:10.2174/1876517301002010001

Cited by 7 publications

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“…ALT and AST are also elevated in cases of injury to other organs like kidney, heart, and muscle (Ortiz et al 2006) and AST in particular for myocardial infarction (Singh et al 2011). Our results are also in accordance with the previous studies carried out by Elagouza et al (2010) where the gradual increase in the serum levels of liver enzymes and bilirubin was observed when administered at an oral dose of 400 mg/kg body weight for 8 weeks. Not only the increase in the activity of liver enzymes was observed but also hydropic degeneration of hepatocyte, focal hepatic necrosis, and fibrosis of bile ducts were observed.…”

Section: Discussionsupporting

confidence: 92%

“…Also, the results obtained by many other coworkers confirmed our findings in which vitamin C prevented kidney, brain, and thymocyte toxicity . In a similar study by Elagouza et al (2010), similar hepatotoxic effects of different doses of MSG were reported and taurine was successfully used as an ameliorating agent. In the present study, vitamin C was successful in significantly decreasing (P<0.05) the AST and ALT activity by 124 and 153 %, respectively, compared to the MSG-treated group.…”

Section: Discussionmentioning

confidence: 64%

“…It is reported that excess glutamate causes overstimulation in the brain, prolongs migraine attacks, and causes neuronal death due to overstimulation. It has been linked to diseases such as obesity (Dolnikoff et al 2001), type 2 diabetes (Nagata et al 2006), and neurotoxicity (Singh et al 2003;Park et al 2000), primarily affecting the liver Diniz et al 2004;Egbuonu et al 2009;Elagouza et al 2010). Since the liver is the central organ of detoxification, it is therefore susceptible to damage through different oxidative processes.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary study on the protective effect of vitamin C on monosodium glutamate-induced hepatotoxicity in rats

et al. 2014

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Monosodium glutamate (MSG) is a food additive with a wide range of biological effects but its high dose and prolonged use can cause a toxic effect on the liver. Therefore, the present study was aimed at investigating the role of vitamin C in MSG-induced hepatotoxicity in rats. MSG was administered to rats (by gavage) at a dose of 6 mg/g body weight for 10 days to induce hepatotoxicity, and vitamin C at a dose of 500 mg/kg body weight was coadministered to evaluate its ameliorating effect by measuring alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in serum; superoxide dismutase (SOD) and catalase activities in liver fraction; lipid peroxidation; and liver weight. It was found that MSG significantly (P<0.05) induced lipid peroxidation (LPO), increased liver weight, and increased activity of SOD and catalase in the liver of animals. The activity of ALT and AST was also increased in the serum on MSG administration. Vitamin C (500 mg/kg) coadministered with MSG significantly reduced LPO and liver weight and decreased the hepatic activity of catalase, but the activity of SOD was not reduced significantly. Also, a significant reduction in ALT and AST activity was observed. MSG induced oxidative stress and hepatic toxicity in the experimental animals at a dose of 6 mg/g body weight. Vitamin C significantly reduced the oxidative stress and hepatic toxicity induced by MSG, thereby providing a protective effect against the MSGinduced hepatotoxicity. The protective effect is associated with decreased LPO and liver weight and decreased activities of catalase, ALT, and AST.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

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Preliminary study on the protective effect of vitamin C on monosodium glutamate-induced hepatotoxicity in rats

et al. 2014

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“…In 21 days old rats, the recorded alterations were represented by nuclear pyknosis, swollen mitochondria with degenerated cristae, dilated rough endoplasmic reticulum, remarkable fat droplets and cytoplasmic vacuolation. Similar results were found in the liver of Albino rats that received MSG for 8 weeks (ElAgouza et al, 2010). Furthermore, the same ultrastructural changes were recorded in the liver cells of MSG treated mothers in addition to obvious dispersed fibrotic areas, fragmented microvilli of bile canaliculi and increased aggregation of glycogen granules.…”

Section: Discussionsupporting

confidence: 82%

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

2016

Res. Opin. Anim. Vet. Sci.

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Monosodium glutamate (MSG) is one of the most widely used food additives as a flavour enhancer but its high dose can induce toxic effects on the liver. Melatonin is a potent antioxidant, could ameliorate acute and chronic hepatic injury. The present work was essentially designed to evaluate the ameliorating role of melatonin on the liver of pregnant female Albino rats and their pups induced by MSG. In the present research, twenty four pregnant Albino rats were divided into four groups (n=6). The control group received saline solution, the melatonin group received 100 mg/kg b.wt, MSG treated group received 400 mg/kg b.wt and ameliorative group received MSG 400 mg/kg b.wt simultaneously with melatonin 100 mg/kg b.wt. All groups were received their corresponding dose from the 4 th day of gestation till the end of weaning period. The histological study of the current work revealed that MSG could induce damage of hepatocytes with cytoplasmic vacuolation, dilation of central vein and blood sinusoids, prominent Kupffer cells, infiltration cells around the portal area, variable degree of fibrosis, and scattered fatty cells. Furthermore, MSG consumption is also associated with ultrastructural alterations that varied considerably from mild structural changes to cytoplasmic lysis and degradation of some cellular organelles. Such alterations were represented by undifferentiated cytoplasm with dispersed vacuoles, nuclear pyknosis, swollen and vacuolated mitochondria, manifested dilated rough endoplasmic reticulum, remarkable aggregation of glycogen granules and fat droplets and obvious dispersion of collagenous fibers. Supplementation of melatonin ameliorated MSG-induced histopathological and ultrastrucural changes in liver cells. Keywords: MSG, Liver, Melatonin, Histopathlology, Fibrosis, TEM, HepatocytesTo cite this article: Abd El-Fattah BM El-Beltagy, 2016. Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate. Res. Opin. Anim. Vet. Sci., 6(2): 59-68.

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“…There is no doubt that taurine is considered as powerful hepatoprotective substance that can protect the hepatocyte through different mechanisms [31,48,49].…”

Section: Discussionmentioning

confidence: 99%

Comparison between Fibroscan and Serum Taurine for Early Diagnosis of Liver Fibrosis in Egyptian Patients Infected with HCV

Agouza¹,

Fouad²,

Ahmed³

et al. 2017

Clin Med Biochemistry

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Aim: The aim is to evaluate the role of measuring serum taurine level as an early biomarker for detection and staging of hepatic fibrosis in comparison to Fibroscan. Patients and methods:70 patients who are positive HCV are classified into five groups according to the scoring of Fibroscan. 10 healthy subjects were also enrolled as control group. Full clinical examination and complete biochemical analysis in addition to fibroscan and serum taurine as new marker are performed for all the selected patients and volunteers. Results:Results showed non-significant changes in the most Analytical data between the five groups of patients and control group, but a significant Increment in the serum level of ALT and AST in F4 Stage is noticed and marked decrease in platelets also found in F4. The most interesting point recorded is that Serum taurine levels were exhibited a value markedly lower than that recorded in control group and its decline was related to the severity of the diseases. Conclusion:It is suggested that the assessment of taurine level in sera of all hepatic patients beside fibroscan are of great value in the early diagnosis of any fibrotic changes in liver.

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The Possible Ultra Structural Ameliorative Effect of Taurine in Rat`s Liver Treated with Monosodium Glutamate (MSG)~!2009-06-12~!2009-11-22~!2010-05-04~!

Cited by 7 publications

References 0 publications

Preliminary study on the protective effect of vitamin C on monosodium glutamate-induced hepatotoxicity in rats

Preliminary study on the protective effect of vitamin C on monosodium glutamate-induced hepatotoxicity in rats

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

Comparison between Fibroscan and Serum Taurine for Early Diagnosis of Liver Fibrosis in Egyptian Patients Infected with HCV

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