The post‐mortem incidence of focal thyroiditis

Williams, E. D.; Doniach, I.

doi:10.1002/path.1700830127

Cited by 168 publications

(71 citation statements)

References 23 publications

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“…Also, lymphocytic infiltration was observed in tissue close to and distant from the tumour. In addition, the prevalence of TgAb and TPOAb in the group of patients we studied was similar to the prevalence observed in the general population with the same assay methods [9], and the prevalence of FLT in the group of patients is also similar to the prevalence of focal thyroiditis observed in post-mortem tissue [10,11]. The presence of serum TgAb and/or TPOAb has been found to be associated with FLT in post-mortem tissue specimens [4] and biopsy samples from patients with enlarged thyroid glands [5].…”

Section: Discussionsupporting

confidence: 79%

Measuring thyroglobulin autoantibodies by sensitive assay is important for assessing the presence of thyroid autoimmunity in areas with high iodine intake

Hamada¹,

Noh

Okamoto

et al. 2010

Endocr J

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Section: Discussionsupporting

confidence: 79%

Measuring thyroglobulin autoantibodies by sensitive assay is important for assessing the presence of thyroid autoimmunity in areas with high iodine intake

Hamada¹,

Noh

Okamoto

et al. 2010

Endocr J

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“…Williams and Doniach [1962] have emphasized the relation between these three conditions in their study of focal thyroiditis in patients with pernicious anaemia coming to post-mortem and in their summary of the literature on the incidence of focal thyroiditis in idiopathic adrenal insufficiency. The popular concept of auto-immunity as the consequence of the release of "hidden" antigen [Doniach and Roitt, 1957;Burnet, 1959;Hijmans et al, 1961] …”

Section: Disciussionmentioning

confidence: 99%

Gastric Antibodies Studied by Fluorescence Microscopy

Irvine

1963

Exp Physiol

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Antibody specific for the mucosa of the body of human stomach was detected by the method of complement-fixation in 62 per cent of patients with Addisonian pernicious anammia, in 20 per cent of patients with Hashimoto thyroiditis, in 25 per cent of patients with spontaneous hypothyroidism, and in 3 per cent of blood donors. Using the technique of fluorescence microscopy the specificity of this gastric antibody has been further defined to a particulate component of parietal cell cytoplasm. It is an auto-antibody that will react equally well with homologous gastric mucosa provided the mucosa contains a normal concentration of healthy parietal cells. The indirect fluorescent antibody technique is a more sensitive test for parietal cell antibody than the method of complementfixation and the incidence of positive results in Addisonian pernicious anoemia, Hashimoto thyroiditis, spontaneous hypothyroidism and blood donors is correspondingly higher at 78, 25, 32 and 4 per cent respectively. Complementfixing gastric antibody is distinct from antibody to intrinsic factor but the latter does not appear to stain any other cell type in the gastric body mucosa with the fluorescent antibody technique.The relationship between pernicious anaemia, chronic thyroiditis and idiopathic adrenal insufficiency is discussed and it is argued that one of the basic factors in the pathogenesis of these three conditions is a genetically determined defect in immunological tolerance.COMPLEMENT-FIXING antibodies to a saline extract of the mucosa of the stomach body were first described by Irvine et al. [1962] in their study of the immunological relationship between Addisonian pernicious anaemia and thyroid disease. The relevant gastric antigen could only be extracted from the body of stomach and not from the pyloric antrum nor from lower levels in the alimentary tract. The presence of gastric complement-fixing antibody in the serum of fourteen patients with spontaneous hypothyroidism was correlated with hypochlorhydria in response to an augmented histamine test. These two observations led to the conclusion that the occurrence of gastric antibodies could be either the result or the cause of damage to the parietal cell mass. The purpose of the present work was to study this gastric antigenantibody reaction in greater detail using the fluorescent antibody technique. MATERIALS AND METHODSThe sera studied were obtained from sixty-seven patients with proven Addisonian pernicious ansemia, 189 patients with either Hashimoto thyroiditis or spontaneous hypothyroidism and from 195 blood donors. While many of the patients with Addisonian pernicious an2emia or thyroid disease were newly diagnosed, others had received treatment for varying periods with parenteral cyanocobalamin or thyroxine.Both the direct and the indirect fluorescent antibody techniques of Coons and Kaplan [1950] have been employed. For the indirect method anti-human globulin conjugated with fluorescein (Progressive Laboratories, Baltimore) was used and for the direct method fluorescein iso...

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“…Further support for such a relationship is provided by the finding of an increased incidence of thyroiditis in patients with pernicious anaemia examined at necropsy (Bastenie, 1937;Williams and Doniach, 1962).…”

mentioning

confidence: 99%

Autoimmune Phenomena in Pernicious Anaemia

Doniach¹,

Roitt²,

Taylor³

1963

BMJ

157

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PARACERvICAL NERVE BLOCK MEDICAL JOURNAL was obvious that very substantial relief of pain was obtained in most cases. Each patient was also carefully questioned, but, in order that the results could be judged with the least possible bias, no comment was made to the patient at the time of the injection, save to explain that an examination was to be made. Ten minutes after the injection the result was assessed by asking the patient, " How are the pains ? " without giving any suggestion of 'expected relief. When recorded and analysed the answers indicated " complete" or " very good " relief of pain in 71%, "partial relief " in 25%, and "no relief " in 4%.These results may be compared with those of other workers, which for this purpose are expressed under similar headings, and on a percentage basis to the nearest unit.

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The post‐mortem incidence of focal thyroiditis

Cited by 168 publications

References 23 publications

Measuring thyroglobulin autoantibodies by sensitive assay is important for assessing the presence of thyroid autoimmunity in areas with high iodine intake

Measuring thyroglobulin autoantibodies by sensitive assay is important for assessing the presence of thyroid autoimmunity in areas with high iodine intake

Gastric Antibodies Studied by Fluorescence Microscopy

Autoimmune Phenomena in Pernicious Anaemia

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