The Posterior Pituitary

Bichet, Daniel G.

doi:10.1016/b978-0-12-380926-1.10008-2

Cited by 8 publications

(8 citation statements)

References 243 publications

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“…Neurophysin II ensures the proper targeting, packing, and storage of vasopressin and functions as a carrier protein for the neuropeptide. 22,23 The exons and introns are cleaved within the Golgi complex of vasopressin synthesizing cells, for example, in the hypothalamic supraoptic nucleus and paraventricular nucleus (PVN), where neurosecretory granules containing the cleavage products are formed. They are passed down nerve axons for storage in the posterior pituitary, where they can be released from nerve terminals into the blood stream.…”

Section: The Vasopressin Genementioning

confidence: 99%

Brain vasopressin signaling modulates aspects of maternal behavior in lactating rats

Bayerl

Bosch

2018

Genes Brain and Behavior

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The brain vasopressin system mediates various social behaviors as has been studied mostly in males. Only recently, advances in social neuroscience revealed that central vasopressin signaling via its V1a and V1b receptors also facilitates female social behavior, including maternal behavior. In this review, we show how maternal care, maternal motivation and maternal aggression of lactating rat mothers are modulated in a V1 receptor subtype- and brain region-specific manner. Measuring local release pattern of vasopressin via intracerebral microdialysis in the behaving rat mother as well as using pharmacological approaches to activate or block vasopressin receptors with subsequent behavioral observation provide detailed insight into the functional role of the vasopressin system in maternal behavior. In this context, the complementary rat animal model of high (HAB) and low anxiety-related behavior (LAB) is particularly helpful due to the genetically determined high activity of the vasopressin gene in HAB rats, which also underlies their high levels of maternal behavior. Furthermore, first studies in humans indicate that the vasopressin system in general and the V1a receptor in more particular might mediate mothering.

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Section: The Vasopressin Genementioning

confidence: 99%

Brain vasopressin signaling modulates aspects of maternal behavior in lactating rats

Bayerl

Bosch

2018

Genes Brain and Behavior

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“…In X-linked disease, NDI is caused by mutations of the AVPR 2 gene, leading to absent signaling for AQP2 insertion into the apical membrane. It is possible to clinically possible to detect mutations in the V2R and the AQP2 genes with genetic sequencing [76]. There are 5 classes of V 2 receptor mutations leading to NDI [1,77]: (I) Abnormal mRNA that is untranslated or leads to aborted proteins (II) Translated proteins that are trapped in the endoplasmic reticulum (III) Proteins that are in the correct location but do not signal in response to ADH (IV) Proteins that are in the correct location but do not bind ADH (V) Proteins that are transported to improper organelles [77].…”

Section: Nephrogenic Diabetes Insipidus (Ndi)mentioning

confidence: 99%

Diabetes Insipidus: A Review

Shapiro¹

2013

J Diabetes Metab

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“…Vasopressin (VP) is a small, COOH-terminally amidated peptide chiefly synthesized by nerve cells, hence designated as a neuropeptide. Arginine-vasopressin is the most common form in mammals, but in some species Arg is replaced by Lys see review by Bichet (14). Vasopressin is elaborated upon the processing of a larger protein precursor—preprovasopressin (15), which is packaged and processed in dense-core secretory granules that are transported to sites of release along the axon as well as the dendrites (15, 16).…”

Section: Vasopressinmentioning

confidence: 99%

“…The neurohemal interface is comprised of the median eminence and the posterior lobe of the pituitary gland also referred to as the neurohypophysis. Magnocellular neurons constitute the classic antidiuretic system that is activated by hypernatremia or hypovolemia and releases VP into the systemic circulation (14). Subsequent work has shown that the axons of magnocellular neurons also release VP en-passant in the internal zone of the median eminence (22–24).…”

Section: Functional Neuroanatomy Of Vasopressinergic Neurons Of the Hmentioning

confidence: 99%

Magnocellular Vasopressin and the Mechanism of “Glucocorticoid Escape”

Antoni

2019

Front. Endocrinol.

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It is now widely accepted that magnocellular vasopressinergic neurons in the supraoptic and paraventricular nuclei participate in the control of adrenocorticotropin secretion by the anterior pituitary gland. However, it remains to be explored in further detail, when and how these multifunctional neurons are involved in the control of anterior pituitary function. This paper highlights the role of magnocellular vasopressin in the hypothalamic pituitary adrenocortical axis with special reference to escape from glucocorticoid feedback inhibition. The signaling mechanisms underlying glucocorticoid escape by pituitary corticotrope cells, as well as the wider physiologic and pathologic contexts in which escape is known to occur—namely strenuous exercise, and autoimmune inflammation will be considered. It is proposed that by inducing escape from glucocorticoid feedback inhibition at the pituitary level, magnocellular vasopressin is critically important for the anti-inflammatory, and immunosuppressant actions of endogenous corticosteroids.

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The Posterior Pituitary

Cited by 8 publications

References 243 publications

Brain vasopressin signaling modulates aspects of maternal behavior in lactating rats

Brain vasopressin signaling modulates aspects of maternal behavior in lactating rats

Diabetes Insipidus: A Review

Magnocellular Vasopressin and the Mechanism of “Glucocorticoid Escape”

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