The Postnatal Development of the Reproductive System of the Golden Hamster (Cricetus auratus) and Its Reactivity to Hormones

Ortiz, Evelina

doi:10.1086/physzool.20.1.30151938

Cited by 32 publications

(13 citation statements)

References 26 publications

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“…In hamsters, effects of several doses in jected postnatally [Brunner and Witschi, 1946;Ortiz, 1947: La Velle, 1951 are quite similar to those reported with a single dose [Alieva et ah, 1969: Justo et ah, 1974, The effects depend on the stages of differentiation of the female and the amounts of the injected hor mones [Brunner and Witschi, 1946;Ortiz, 1947;Alieva et ah, 1969: Justo et ah, 1974, Postnatal injection of a single dose of testo sterone propionate produces various degrees of perineal malformations [Brunner and Wit schi, 1946: La Velle, 1951: Alieva et ah, 1969Justo et ah, 1974], Details of external genitalia malformations have been reported [Justo et ah, 1974]: the clitoris is enlarged [Ortiz, 1947: La Velle, 1951: Justo et ah, 1974, the urogenital sinus is markedly masculinized [Brunner and Witschi. 1946;ha Velle, 1951], the upper vagina narrows caudally to join the urethra (at the level of the superior ridge of the symphysis) through a pinhole pore [Brunner andWitschi, 1946: La Velle, 1951].…”

Section: Discussionmentioning

confidence: 99%

“…In hamsters it takes place around the 30th day of life [Deanes!v, 1938;Ortiz, 1947;La Velle, 1951], so that one may infer that vaginal epithelium changes might be due to the ovarian hormone secretion.…”

Section: Discussionmentioning

confidence: 99%

“…Estradiol effects depend upon the age of the animals [Ortiz, 1947;White, 1949;Fors-berg el al.. 1968], the doses [Forsberg and Lannerstad, 1968] and the kind of drug used [Forsberg el ai, 1968;Forsberg and Lanner stad, 1968], As in testosterone-propionate-treated ani mals, estradiol benzoate injections in neo natal animals produce malformations of the clitoris in rats [Tramezzani el al., 1963] and are related to strain [Heinrich el al., 1964]; in mice 1964;Fors berg and Lannerstad, 1968] and hamsters [Justo et al, 1974] they are accompanied by hypospadia, with a common duct of urethra and vagina reaching to the exterior [Forsberg and Lannerstad, 1968] or urethral opening in the vagina [Dunn and Green, 1963]. In hamsters, the vagina opens to the exterior, forming a short common duct with the urethra.…”

Section: Discussionmentioning

confidence: 99%

“…In an earlier paper wc reported that in testosterone-propionate-administered hamsters va ginal opening occurs at the 9-IOth day of life (Jus to et al, 1974], Regarding the effects of estradiol benzoate: pre natal injections determine no changes when the autopsy is performed before birth [White, 1949]; postnatal injections produce external genitalia abnormalities [Jttstu et al, 1974], but Swanson [1966] reported no changes. Vaginal opening was recorded by Ortiz [1947] at 6 days and by Jttsto et al, [1974] at 9 days of life.…”

Section: Hisanomentioning

confidence: 99%

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Effects on hamster vaginal development of a single dose of testosterone or estradiol given neonatally

Hisano¹

1977

Cells Tissues Organs

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Postnatal injections of a single dose of testosterone propionate or estradiol benzoate to newborn female hamsters produce a precocious vaginal opening at 5 days of age. Vaginal postnatal development, histologically, has shown that in testosterone-propionate-injected animals sinusal vagina is absent. The Müllerian vagina presented a stimulated epithelium at early ages. After 40 days, the Müllerian epithelium was stratified keratinized, with zones of stratified cuboidal epithelium. In estradiol-benzoate-treated animals, the Müllerian epithelium rapidly changes to stratified keratinized epithelium (10 days), with zones of stratified cuboidal after 20 days of life. The sinusal epithelium was stratified squamous at 10 days, and after 40 days changes to stratified keratinized epithelium were seen. Probably, early changes are due to a direct effect of steroid action. Later effects are due to ovarian secretion. Histologically, no significant changes were observed in the preputial and urethral glands. The clitoris showed malformations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Hisanomentioning

confidence: 99%

See 2 more Smart Citations

Effects on hamster vaginal development of a single dose of testosterone or estradiol given neonatally

Hisano¹

1977

Cells Tissues Organs

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“…In the hamster, the vaginal opening is an early event, which takes place long before the first estrous. In this species the vagina opens on the 8-10th day of life [Deanesly, 1938: Ortiz, 1947La i'elle, 1951: Forsberg, I960;Jasto el at., 1974], whereas estrus and ovulation occur around the 30th day of life [Deanes!y, 1938;Ortiz, 1947],…”

Section: Introductionmentioning

confidence: 99%

Postnatal development of vagina, clitoris and urethral glands of the golden hamster

Hisano¹

1977

Cells Tissues Organs

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We have made a histological study of the postnatal development of the clitoris, preputial glands, urethral glands and vagina of the golden hamster. The ‘phallic groove’ of the clitoris is closed at 10 days of life, then the urethra has a cuboidal stratified, a stratified squamous and a stratified keratinized epithelium. The preputial glands are composed of branched saccular glands. These glands develop, with few changes during their maturation period. Formation of the urethral glands begins at 5 days and the alveoli are fully developed at puberty. The hamster vagina has two origins; the upper part is Müllerian, the caudal part is sinusal. The wall of the Müllerian vagina has a cylindrical epithelium at birth, which becomes ‘double epithelium’ at puberty and thereafter changes cyclically in connection with the estrous cycle. The sinusal vagina is solid at birth, its lumen being formed in the first 10 days of life and its wall having a cuboidal stratified epithelium. At 15 days it becomes a stratified keratinized epithelium, which will later line the vaginal pouch. At the 5th day, an ectodermic invagination (stratified keratinized epithelium) is observed in the zone of the future introitus. At the time of vaginal opening this zone forms the distal segment.

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Development of the flank organ (scent gland) of the Syrian hamster II. Postnatal development

1966

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In the first paper of this series, the prenatal development of the flank organ (scent gland) of the Syrian hamster was described. The present paper is concerned with the postnatal development of this organ. The embryology of the organ actually continues into postnatal life, until, during the fifth day, the organ attains the degree of development characteristic of general body skin at birth. Subsequently, an accelerated growth rate results in a conspicuous and characteristic hypertrophy of the gland relative to surrounding integument. During the acquisition of this hypertrophy two opposite developmental gradients are involved, i.e., a series of consecutive centripetal waves of hair cycling and a centrifugal gradient of sebaceous gland development. Maturation of the gland, including changes in its pigmentation and the onset of sexual dimorphism, is discussed in relation to pertinent literature.

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The Postnatal Development of the Reproductive System of the Golden Hamster (Cricetus auratus) and Its Reactivity to Hormones

Cited by 32 publications

References 26 publications

Effects on hamster vaginal development of a single dose of testosterone or estradiol given neonatally

Effects on hamster vaginal development of a single dose of testosterone or estradiol given neonatally

Postnatal development of vagina, clitoris and urethral glands of the golden hamster

Development of the flank organ (scent gland) of the Syrian hamster II. Postnatal development

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