The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s Adjuvant

Abstract

The using of herbal plants in Indonesia as medicine based on traditional knowledge. One of the herbal plants that believed has medication effect is bay leaves (Syzygiumpolyanthum). Bay leaves contain a flavonoid that can prevent inflammation. The study aims to prove the potency of bay leaves extract to prevent the inflammation, which is indicated by decreasing the paw edema thickness in rat induced with Complete Freund's Adjuvant (CFA). This study used 25 animal models of male rat (Rattus norvegicus) strain Wistar that divided into five groups, one group for a normal group (no treatment), one group for positive control which was injected with CFA sub plantar and given treatment with Na CMC and three test groups which is got three different doses of bay leaves extract peroral and the doses were 100 mg/kg BW, 300 mg/kg BW, 400 mg/kg BW, and injected with CFA into the sub plantar. Bay leaves extract was given one hour per oral before injected with CFA. The measurement of paw edema was done at 24 hours after CFA injection. The result of this study showed that bay leaves extract gave the anti-inflammation effect to the rats which were injected with CFA. It is concluded that bay leaves extract containing flavonoids plays a role in inhibit cytokines proinflammatory synthesis.

Production of bay leaf instant powder drink using different amounts of rock sugar to the level of preference and nutrient content (carbohydrates and flavonoids)

“…Glycosides and flavonoids in bay leaf have been proved to reduce hyperlipidemia [5]. In addition, bay leaf extract contains flavonoids that can inhibit NFB, which has an important role in the synthesis of proinflammatory cytokines such as TNF-and IL-1β [6]. Some of the vitamins contained in bay leaf include vitamin C, vitamin A, thiamin, riboflavin, niacin, vitamin B6, vitamin B12, and folate.…”

Aqueous extract of bay leaf (Laurus nobilis) ameliorates testicular toxicity induced by aluminum chloride in rats

“…L. nobilis, generally known as bay, is a native Mediterranean evergreen shrub that is widely grown in West Asia, South Europe, North Africa, and America [27]. The therapeutic potential of L. nobilis has been widely reported [28][29][30][31][32][33]. However, despite numerous studies on L. nobilis, there is a paucity of information regarding its protective role in male infertility induced by aluminum toxicity.…”