The potency of KUL-7211, a selective ureteral relaxant, in isolated canine ureter: comparison with various spasmolytics

Wanajo, Isao; Tomiyama, Yoshitaka; Tadachi, Mariko; Kobayashi, Mamoru; Yamazaki, Yoshinobu; Kojima, Masami; Shibata, Nobuhiko

doi:10.1007/s00240-005-0475-5

Cited by 22 publications

(11 citation statements)

References 14 publications

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“…If after 24 hours there is no evidence of improvement based on imaging this is discontinued. Other medical considerations include amitriptyline, 37 α‐adrenergic blockade (prazosin or tamsulosin), 38 or glucagon therapy e . In cats only anecdotal evidence exists regarding the medical management strategies discussed.…”

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confidence: 99%

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Ureteral obstructions in dogs and cats: a review of traditional and new interventional diagnostic and therapeutic options

Berent

2011

J Vet Emergen Crit Care

129

162

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confidence: 99%

“…In cats only anecdotal evidence exists regarding the medical management strategies discussed. One study evaluated the response of normal canine ureters and compared various spasmolytics 38 . In people, α‐1 adrenergic antagonists, eg, tamsulosin (α‐1a/1d adrenergic antagonist), was the treatment of choice for the expulsion of small ureteral stones.…”

mentioning

confidence: 99%

Ureteral obstructions in dogs and cats: a review of traditional and new interventional diagnostic and therapeutic options

Berent

2011

J Vet Emergen Crit Care

129

162

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“…We have routinely been giving our patients 20 mg of intravenous butylscopolamine (a non-selective muscarinic antagonist) prior to ureteroscopy (unless contraindicated) to try and relax the ureteric smooth muscle and potentially reduce the need for an access sheath. Although we acknowledge the effect at low doses may be limited, there is evidence in the literature that butylscoplomine causes ureteric smooth muscle relaxation [6]. …”

Section: Discussionmentioning

confidence: 99%

The New Digital Flexible Ureteroscopes: ‘Size Does Matter’ – Increased Ureteric Access Sheath Use!

et al. 2012

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Objectives: To evaluate whether the use of sheaths to access the ureter has increased after the introduction of new digital ureterorenoscopes in patients undergoing flexible ureteroscopy. Methods: 140 patients with kidney stones were randomised to be scoped with either an old-generation fibre-optic flexible ureteroscope (DUR-8, Elite, ACMI; distal tip diameter = 6.75 Fr) or a new-generation digital LCD flexible ureteroscope (Invisio D-URD flexible ureteroscope; distal tip diameter = 8.7 Fr). We recorded the necessity to use a sheath to access the ureter, sheath-related and postoperative complications, and whether or not a JJ stent was left behind. Results: 157 (80 fibre-optic and 77 digital) ureterorenoscopies were performed. Ureteral access sheaths were used significantly more frequently with digital scopes (p = 0.00174). Two patients in the digital scope group had a small distal ureteric perforation from the introducer sheath compared with none in the fibre-optic scope group. Conclusions: A statistically significant increase in sheath use was observed in the new-generation digital flexible ureteroscopy group. Despite the improvement in image quality, better durability and improved stone clearance, there are some potential drawbacks of these scopes. The increased distal tip diameter can result in increased use of ureteric access sheaths and this may increase morbidity and expense.

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“…30 Prazosin has also been evaluated in dog ureters but was shown to have little effect and may even contribute to increased ureteral contractions at high levels. 31 If no movement of an obstructive ureterolith is seen on serial imaging performed over 48-72 h, or if azotemia and electrolyte disturbances worsen in the face of therapy, more aggressive treatment is indicated. Such interventions include RRT, placement of nephrostomy tubes, ureteral stenting ( Figure 3c) and/or ureterotomy or ureteroneocystotomy for relief of obstruction.…”

Section: Infectious Nephropathymentioning

confidence: 99%

Feline acute kidney injury

Monaghan

Nolan²,

Labato

2012

Journal of Feline Medicine and Surgery

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Practical relevance: Acute kidney injury (AKI) is a frequently recognized disease process in cats that requires immediate and aggressive intervention. A thorough understanding of the pathophysiologic processes underlying AKI and familiarity with the most common etiologies are essential for providing the most effective and timely therapy. Possessing this knowledge will also allow a more accurate prognosis to be given, and afford the best chance of a favorable outcome. Clinical challenges:Feline patients often present with vague signs of AKI, which may delay treatment and adversely affect the prognosis. Their response to injury and treatment is often different to that of other species.Audience: This two-part review article is directed at small animal practitioners as well as specialists. Part 1 reviews mechanisms underlying AKI in the cat, as well as etiologies and treatments related to some specific causes of AKI. New terminology -and a new emphasisAcute kidney injury (AKI) is a relatively new term in the nephrology literature that largely replaces the use of 'acute renal failure' (ARF). Originally introduced in the human literature, AKI allows for greater stratification of cases with regard to severity and prognosis. By suggesting that a patient has injury, rather than failure, one can recognize the potential for earlier treatment and recovery. In human medicine, the older term 'ARF' refers only to patients requiring renal replacement therapy (RRT). Additionally, the more common term 'kidney', rather than 'renal', facilitates communication with and understanding by clients of AKI. The incidence of AKI in cats is not known, but it is not uncommon and can be caused by a variety of different insults. A uniform definition for AKI does not exist in the veterinary literature and varies among publications. Generally accepted criteria include an abrupt reduction in kidney function resulting in alterations in glomerular filtration, urine production and tubular function. These alterations result in an inability to maintain fluid, electrolyte and acid-base balance, and may lead to azotemia. PathophysiologyThe pathophysiology of AKI is complex, but can be described by four stages: initiation, extension, maintenance and recovery.

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The potency of KUL-7211, a selective ureteral relaxant, in isolated canine ureter: comparison with various spasmolytics

Cited by 22 publications

References 14 publications

Ureteral obstructions in dogs and cats: a review of traditional and new interventional diagnostic and therapeutic options

Ureteral obstructions in dogs and cats: a review of traditional and new interventional diagnostic and therapeutic options

The New Digital Flexible Ureteroscopes: ‘Size Does Matter’ – Increased Ureteric Access Sheath Use!

Feline acute kidney injury

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