The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells???preliminary comparisons to paclitaxel

Balachandran, Raghavan; Haar, Ernst ter; Welsh, Manda J.; Grant, Stephen G.; Day, Billy W.

doi:10.1097/00001813-199801000-00008

Cited by 57 publications

(32 citation statements)

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“…An agent that blocks PSA production could thus be useful in cases where PSA levels are indicative of prostatic hyperplasia. Because A II initiates cell cycle perturbations and apoptosis in breast cancer epithelial cells [39,49,50] and the sites of its cellular actions are potential targets for anti-CaP chemotherapy, androgensensitive LNCaP, and androgen-independent PC-3 cell lines were used in this study to investigate the potential usefulness of Z-1,1-dichloro-2,3-diphenylcyclopropanes against CaP.…”

Section: Introductionmentioning

confidence: 99%

Z-1,1-Dichloro-2,3-diphenylcyclopropanes block human prostate carcinoma cell proliferation, inhibit prostate-specific antigen expression, and initiate apoptosis

et al. 2000

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Section: Introductionmentioning

confidence: 99%

Z-1,1-Dichloro-2,3-diphenylcyclopropanes block human prostate carcinoma cell proliferation, inhibit prostate-specific antigen expression, and initiate apoptosis

et al. 2000

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“…Many marine natural compounds affect microtubule dynamics (recently reviewed in Reference [33]) and can induce apoptosis as a result; examples include discodermolide [34] and leiodermatolide [35]. Discodermolide can also initiate caspase-independent cell death thought to be initiated by mitotic catastrophe in non-small cell lung cancer cells [36].…”

Section: Caspase Dependent Apoptosismentioning

confidence: 99%

Regulated Cell Death Signaling Pathways and Marine Natural Products That Target Them

Guzmán

2019

Marine Drugs

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Our understanding of cell death used to consist in necrosis, an unregulated form, and apoptosis, regulated cell death. That understanding expanded to acknowledge that apoptosis happens through the intrinsic or extrinsic pathways. Actually, many other regulated cell death processes exist, including necroptosis, a regulated form of necrosis, and autophagy-dependent cell death. We also understand that apoptosis occurs beyond the intrinsic and extrinsic pathways with caspase independent forms of apoptosis existing. Our knowledge of the signaling continues to grow, and with that, so does our ability to target different parts of the pathways with small molecules. Marine natural products co-evolve with their targets, and these unique molecules have complex structures with exquisite biological activities and specificities. This article offers a review of our current understanding of the signaling pathways regulating cell death, and highlights marine natural products that can affect these signaling pathways.

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“…The IC 50 s for discodermolide in breast, prostate, colon, lung and ovarian cell lines vary between below 2.5 and 50 nM [31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

The clinical development of new mitotic inhibitors that stabilize the microtubule

et al. 2004

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Microtubule-stabilizing agents are increasingly studied for cancer treatment based largely on the prior success of paclitaxel and docetaxel. In this review, we focus on the clinical development of epothilones and discodermolide, and we discuss salient preclinical and clinical highlights of these two novel natural products. These agents are distinguished by their biochemical features making them poor P-glycoprotein substrates and capable of inducing cytotoxicity in cell lines or in vivo tumor models harboring mutations in tubulin. There is now considerable data regarding the efficacy of the epothilones in human beings and discodermolide holds such promise, as well.

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The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells???preliminary comparisons to paclitaxel

Cited by 57 publications

References 0 publications

Z-1,1-Dichloro-2,3-diphenylcyclopropanes block human prostate carcinoma cell proliferation, inhibit prostate-specific antigen expression, and initiate apoptosis

Z-1,1-Dichloro-2,3-diphenylcyclopropanes block human prostate carcinoma cell proliferation, inhibit prostate-specific antigen expression, and initiate apoptosis

Regulated Cell Death Signaling Pathways and Marine Natural Products That Target Them

The clinical development of new mitotic inhibitors that stabilize the microtubule

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