The Potential and Challenges of Creatine Supplementation for Cognition/Memory in Older Adults

Abstract

The following databases were searched: PubMed, PsychInfo, EBSCO, Medline, BioMed central, and Science Direct. Inclusion criteria specified peer-reviewed studies investigating creatine metabolism and/or creatine supplementation, and assessing cognition, and memory in old adults, and published between January, 2000 to September, 2022. Each author searched for articles separately based on the descriptors "creatine supplementation", "old people", "elderly", and "aging". After removing duplicate articles and abstracts that did not meet the inclusion criteria, only common articles selected by the authors were adopted.

Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults

“…This suggests that Cr has the ability to supply energy and help with functioning in the central nervous system (CNS). In line, Cr supplementation may promote better cognitive function during conditions characterized by fluctuating ATP turnover, such as hypoxia [ 9 ], mild traumatic brain injury [ 5 ], sleep deprivation [ 10 ], and complex cognitive tasks in older adults [ 11 ].…”

Role of creatine and creatine precursors supplementation on cardiovascular system physiology and pathophysiology

“…), leading several researchers to observe the relationship between dietary consumption and supplementation in different tissues and organs. 3,6 Hence, the relationship between the lack or reduction in creatine concentrations and the etiology of several diseases (main mutations in the genes Guanidinoacetate N-methyltransferase [GAMT], Arginine: glycine amidinotransferase[AGAT], and solute carrier family 6 member 8 [SLC6A8] and myodegenerative diseases), as well as the use of creatine supplementation as an adjuvant in the treatment of these as well as other diseases. 3,[7][8][9] Creatine supplementation started to be used with different levels of success in neurology, geriatrics and gerontology, orthopedics, physiatry, endocrinology, and other specialties.…”