The potential application of encapsulated exosomes: A new approach to increase exosomes therapeutic efficacy

Hazrati, A.; Mirsanei, Zahra; Heidari, N.; Malekpour, Kosar; Rahmani-Kukia, Nasim; Abbasi, Ardeshir; Soudi, Sara

doi:10.1016/j.biopha.2023.114615

Cited by 15 publications

(8 citation statements)

References 132 publications

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“…However, the customization of release kinetics, loading efficiency, and storage stability necessitate additional material engineering upgrades. In addition, functional measurements of exosome bioactivity in clinically relevant in vivo models are needed 79 - 82 . Innovative strategies for biomaterial design and cell-free therapeutic methods reveal the possibilities of exosomes in the realm of tissue regeneration.…”

Section: Fabrication Of Exosome-loaded Biomaterialsmentioning

confidence: 99%

Engineered exosomes and composite biomaterials for tissue regeneration

Hu,

Wang,

Chen

et al. 2024

Theranostics

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Exosomes, which are small vesicles enclosed by a lipid bilayer and released by many cell types, are widely dispersed and have garnered increased attention in the field of regenerative medicine due to their ability to serve as indicators of diseases and agents with therapeutic potential. Exosomes play a crucial role in mediating intercellular communication through the transfer of many biomolecules, including proteins, lipids, RNA, and other molecular constituents, between cells. The targeted transport of proteins and nucleic acids to specific cells has the potential to enhance or impair specific biological functions. Exosomes have many applications, and they can be used alone or in combination with other therapeutic approaches. The examination of the unique attributes and many functions of these factors has emerged as a prominent field of study in the realm of biomedical research. This manuscript summarizes the origins and properties of exosomes, including their structural, biological, physical, and chemical aspects. This paper offers a complete examination of recent progress in tissue repair and regenerative medicine, emphasizing the possible implications of these methods in forthcoming tissue regeneration attempts.

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Section: Fabrication Of Exosome-loaded Biomaterialsmentioning

confidence: 99%

Engineered exosomes and composite biomaterials for tissue regeneration

Hu,

Wang,

Chen

et al. 2024

Theranostics

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“…Mesenchymal stem cell-derived exosomes (MSC-Exos) have been used as a new strategy for the therapy of ulcerative colitis. , Compared with traditional treatment methods, MSC-Exos have excellent biocompatibility, active targeting ability, the ability to aggregate at specific lesion sites for effect, and no toxic side effects . However, intravenous therapy for ulcerative colitis may cause some exosomes to remain in the liver and lungs, resulting in poor therapeutic effect.…”

Section: Application Of Engineered Exosomesmentioning

confidence: 99%

“…138,139 Compared with traditional treatment methods, MSC-Exos have excellent biocompatibility, active targeting ability, the ability to aggregate at specific lesion sites for effect, and no toxic side effects. 140 However, intravenous therapy for ulcerative colitis may cause some exosomes to remain in the liver and lungs, resulting in poor therapeutic effect. For instance, Deng et al have used a layer-by-layer (LbL) selfassembly technique to construct an efficient LbL-Exos exosome, which could be released in colitis and alleviate ulcerative colitis by controlling the MAPK/NF-ΚB signaling pathway.…”

Section: Application Of Engineered Exosomesmentioning

confidence: 99%

Research Advances of Engineered Exosomes as Drug Delivery Carrier

Huang,

Wu,

Liao

et al. 2023

ACS Omega

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Exosomes are nanoscale vesicles secreted by living cells that have similar membrane composition to parental cells and carry a variety of proteins, lipids, and nucleic acids. Therefore, exosomes have certain biological activities and play an important role in intercellular communication. On the basis of its potential as a carrier for drug delivery systems, exosomes have been engineered to compensate for the shortage of natural exosomes through various engineering strategies for improving drug delivery efficiency, enhancing targeting to tissues and organs, and extending the circulating half-life of exosomes. This review focuses on the engineered exosomes loading drugs through different strategies, discussions on exosome surface modification strategies, and summarizes the advantages and disadvantages of different strategies. In addition, this review provides an overview of the recent applications of engineered exosomes in a number of refractory and relapsable diseases. This review has the potential to provide a reference for further research and development of engineered exosomes.

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“…An increasing body of evidence suggests that exosomes can promote the proliferation, metastasis and angiogenesis of pancreatic cancer cells(PCCs), and also show great potential value in the early diagnosis, treatment and other clinical applications of PC ( 7 ). For example, engineered exosomes for targeted delivery of drugs and various miRs lead to better tumor regression than intact exosome applications ( 8 , 9 ). Therefore, it is particularly important to reveal the role of exosomes in PC, which can lead to a better orientation of researchers toward early diagnosis and new treatment of PC based on exosomes.…”

Section: Introductionmentioning

confidence: 99%

Knowledge mapping and research trends of exosomes in pancreatic cancer: a bibliometric analysis and review (2013-2023)

Zhou,

Feng,

Wang

et al. 2024

Front. Oncol.

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ObjectiveThis review aims to provide a quantitative and qualitative bibliometric analysis of literature from 2013 to 2023 on the role of exosomes in PC, with the goal of identifying current trends and predicting future hotspots.MethodsWe retrieved relevant publications concerning exosomes in PC, published between 2013 and 2023, from the Web of Science Core Collection. Bibliometric analyses were conducted using VOSviewer(1.6.19), CiteSpace(6.2.R4), and Microsoft Excel (2019).ResultsA total of 624 papers were analyzed, authored by 4017 researchers from 55 countries/regions and 855 institutions, published in 258 academic journals. China (n=285, 34.42%) and the United States (n=183, 24.87%) were the most frequent contributors and collaborated closely. However, publications from China had a relatively low average number of citations (41.45 times per paper). The output of Shanghai Jiao Tong University ranked first, with 28 papers (accounting for 4.5% of the total publications). Cancers (n=31, 4.9%); published the most papers in this field. Researcher Margot Zoeller published the most papers (n=12) on this topic. Research hotspots mainly focused on the mechanisms of exosomes in PC onset and progression, the role of exosomes in PC early diagnosis and prognosis, exosomes promote the development of PC chemoresistance, and potential applications of exosomes as drug carriers for PC therapies. We observed a shift in research trends, from mechanistic studies toward clinical trials, suggesting that clinical applications will be the focus of future attention. Emerging topics were pancreatic stellate cells, diagnostic biomarkers, mesenchymal stem cells, extracellular vesicles.ConclusionOur scientometric and visual analysis provides a comprehensive overview of the literature on the role of exosomes in PC published during 2013–2023. This review identifies the frontiers and future directions in this area over the past decade, and is expected to provide a useful reference for researchers in this field.

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The potential application of encapsulated exosomes: A new approach to increase exosomes therapeutic efficacy

Cited by 15 publications

References 132 publications

Engineered exosomes and composite biomaterials for tissue regeneration

Engineered exosomes and composite biomaterials for tissue regeneration

Research Advances of Engineered Exosomes as Drug Delivery Carrier

Knowledge mapping and research trends of exosomes in pancreatic cancer: a bibliometric analysis and review (2013-2023)

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