The potential curative and hepatoprotective effects of platelet rich plasma on liver fibrosis in Schistosoma mansoni experimentally infected mice

Bayoumi, Angham M. A.; Ismail, Mousa A. M.; Mahmoud, Soheir; Soliman, Ahmed; Mousa, Amr Mousa Abdel Gawad; Yousof, Hebat Allah Salah A.

doi:10.1007/s12639-023-01576-9

Cited by 2 publications

(1 citation statement)

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“…The review would provide an updated synopsis of the intensively investigated role of various forms of PRP and its allied derivatives as therapeutics in treating tissue pathology and aiding in tissue regeneration via evidence-based assessment of the different isolation and characterization protocols. PRP [8][9][10] and PRF [11][12][13] are two major blood derivatives that have found application as potential biomaterials, patient-specific treatment strategy, alongside being used extensively in regenerative medicine for the past several decades or as a substitute for xenogeneic sera in cell-based therapies. This mitigates the risks and outrageous economic burden associated with the current non-steroidal anti-inflammatory drugs and surgical techniques for tissue repair.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in platelet-rich plasma and its derivatives: therapeutic agents for tissue engineering and regenerative medicine

Shome,

Kodieswaran,

Dadheech

et al. 2024

Prog. Biomed. Eng.

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Platelet rich plasma (PRP) is a suspension of bioactive factors and chemokine enriched plasma. Platelets are a distinctive source of membrane bound and soluble proteins that are released upon their activation. The higher count of platelets renders PRP with an array of tissue regenerative abilities. PRP can be employed in the form of platelet containing plasma, platelet lysate plasma, or in the form of a pre-gelled fibrin matrix. PRP has been an essential alternative source of growth factors in the healing and regeneration of various tissues, such as musculoskeletal, cardiovascular, and dermal tissue, with additional applications in other tissues, such as hepatic and neural. A wide range of preparative and isolation strategies have been developed for various forms of PRP at laboratory and commercial scales. Concomitantly, PRP has found its applicability as an active component in several tissue regenerative approaches, including 3D printed/bioprinted constructs, injectable hydrogels, and crosslinked scaffolds. This review focuses on the various forms of PRP and their preparation methods, the latest tissue engineering applications of PRP, and the various tissue-specific clinical trials and findings conducted using PRP. We have further discussed the optimizations required in the methods of preparation, delivery, and long-term storage of PRP. Therefore, this review seeks to benefit the scope of research on PRP-based therapeutic agents in tissue engineering by providing comprehensive insights into the widespread application. We believe PRP could be instrumental in future patient-specific tissue engineering applications in both pre-clinical and clinical settings.

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