The potential effect and delivery of piperine on breast cancer

Wihandani, Desak Made; Saputra, I Putu Gede Septiawan; Remitha, Ni Putu Sri Indrani; Indrakusuma, Anak Agung Bagus Putra; Adiputra, Putu Anda Tusta; Supadmanaba, I Gede Putu

doi:10.15562/bmj.v10i2.2247

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“…PD-L1 expression was elevated in individuals with high histological grades, according to the findings of this investigation, as well as positive lymph node status. There was no connection between PD-L1 overexpression and age, tumor size, estrogen receptors, progesterone receptors, HER2 expression, Ki67 index, tumor stage, chemotherapy, or radiation in this investigation (Rizka et al, 2021;Wihandani et al, 2021). A substantial correlation between high PD-L1, high histological grade and the presence of lymph node metastases was consistent with decreased patient survival.…”

Section: Discussionmentioning

confidence: 51%

Analysis of PD-L1 Expression in Breast Cancer: A Systematic Review and Meta-Analysis in Asian Population

Adiputra

Sudarsa

Wihandani

et al. 2023

Asian Pac J Cancer Prev

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Objective: This study aimed to investigate the level of PD-L1 protein expression in patients with BCs who were of Asian descent. Methods: Three databases were conducted on this article up to August 10th, 2022. The reference lists of the publications were examined for further studies, and in cases of duplicates, a study with a larger sample size was added. In survival analysis, the hazard ratio (HR) was applied to the circumstances characterized by the frequency of occurrences, and for the clinicopathological characteristic, the best-adjusted odds ratio (OR) with a 95% confidence interval (CI) was employed. The Newcastle-Ottawa Scale (NOS) was utilized to evaluate selection criteria, comparison, and exposure to establish the quality of the technique in the under-consideration studies. The Z test determined the association analysis of OS, DFS, and clinicopathological characteristics with PD-L1 expression. Result: All eight trials for OS and six for DFS were considered, with 4.111 and 3.071 participants, respectively. Overexpression of PD-L1 was linked to a reduced OS compared to individuals with undetectable expression (HR= 1.58, 95% CI 1.04–2.40; P=0.03). We analyzed clinicopathological features, and it elevated in individuals with histological grade III (OR=2.39, 95% CI 1.26-4.54; P=0.008) and positive node (OR=0.68, 95% CI 0.48-0.97; P<0.05). Conclusion: Overexpression of PD-L1 was associated with a shorter OS in BCs patients. High PDL1 was higher in persons with nodal positivity and histological grade III.

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Section: Discussionmentioning

confidence: 51%