The Potential Effect of Citrus Sinensis Extract on Malondialdehyde (MDA) Levels in Rat Induced by Cigarette Smoke

Abstract

Cigarette smoke contains numerous substances containing free radicals and can prompt oxidative pressure. The buildup of free radicals cannot be neutralized by antioxidants for essential cancer prevention agent supplements from outside. In relation to that, the peel of citrus sinensis is expected to contain cell reinforcements that may eliminate free radicals. This study aims to determine the potential effect of Citrus sinensis peel extract on MDA levels in rats induced by cigarette smoke. This investigation is an experimental study with pre and post-test control groups. The 25 subjects of Rattus Norvergicus were divided into five groups: normal group, positive group, Treatment 1 (37.5 mg/kg BW Citrus sinensis peel extract), Treatment 2 (75 mg/kg BW Citrus sinensis peel extract) and Treatment 3 (112.5 mg/kg BW Citrus sinensis peel extract). Analysis of statistics resulted in a huge distinction between pre-test and post-test with p-value <0.05 (Wilcoxon test). Consequently, the Kruskal-Wallis was applied to distinguish the expansion of MDA levels pre-test and post-test. The investigation showed that the distinction was in the most significant levels in the positive group (7.71 nmol/mL), the least in the negative group (0.09 nmol/mL), and 37.5 mg/kg Citrus sinensis peel extract group (0.96 nmol/mL) was the most reduced among the treatment groups. There are huge contrasts in all treatment groups with p = 0.000 (p <0.05). The investigation inferred that the concentrate of Citrus sinensis could lessen levels of MDA in Rattus Norvergicus prompted by cigarette smoke.

Chrysophyllum albidum (African star apple) Fruit-Skin Attenuates Hyperglycemia-Mediated Oxidative Stress in Experimental Diabetic Rats

“…Food supplementation with CAFS to diabeticinduced rats in the present studies notably declined the levels of serum, hepatic as well as pancreatic lipid peroxides. This observation is consistent with Ochuko et al (2012) in tissues of the brain of diabetic rats was reported after treatment with a certain plant fiber and also Setyawati and Hidayati (2021), who reported decreased in MDA concentration after treating rat induced by cigarette smoke with orange peel (Citrus sinensis) extract. This effect could be traced to the free radical scavenging and antioxidant potentials of CAFS.…”