The potential effect of garlic extract and curcumin nanoparticles against complication accompanied with experimentally induced diabetes in rats

Abdel‐Mageid, Afaf D.; Abou-Salem, M.E.; Salaam, Nancy M.H.A.; El-Garhy, Hoda A.S.

doi:10.1016/j.phymed.2018.04.039

Cited by 52 publications

(24 citation statements)

References 56 publications

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“…There were great variations among the type of polyphenol, the nanocarrier and nanoencapsulation technique used, the size of the nanomaterials, the drug delivery system, the dose of nanopolyphenol administered, the encapsulation efficiency and loading capacity of the resulting nanomaterials and the study duration. With these variations, superior anti-diabetic effects of the nanopolyphenols were still evident in all but 4 of the 33 included studies [68,78,101,106]. Of these 4 studies, 3 compared the efficacy of the nanodrug to its freeform while the other did a comparison with untreated diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

“…Comparison of the effect of the nanoencapsulated polyphenol was done with the polyphenol-void nanocarrier, other bioactives/pharmaceuticals, and also with its free-form. The biological effects and conditions assessed included anti-diabetic and antioxidant activity [63,97,98], diabetic neuropathic pain [99,100], diabetic cardiomyopathy [101,102], inflammation [103][104][105], and cataract in a diabetic rat model [106]. It was reported that nanoencapsulated curcumin produced anti-diabetic effects by increasing the number of insulin positive cells and the gene expression of insulin, alleviating STZ-induced β-cell damage and increasing the upregulation of the transcription factors pancreatic and duodenal homeobox 1 (Pdx-1), which play a critical role in pancreatic development, and NKx6.1 which is required for the development of β-cells [97,98].…”

Section: Diarylheptanoidmentioning

confidence: 99%

“…There were however non-significant effects on glucose and insulin compared to untreated diabetic rats [102]. Increases in the following parameters were also reported: hydrogen sulfide (H 2 S), CaSR, CSE and CaM [101]. Diabetic cardiomyopathy is a type of cardiovascular damage in diabetic patients that is independent of the coexistence of ischemic heart disease or hypertension.…”

Section: Diarylheptanoidmentioning

confidence: 99%

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Nanopolyphenols: a review of their encapsulation and anti-diabetic effects

Rambaran

2020

SN Appl. Sci.

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Polyphenols are believed to possess numerous health benefits and can be grouped as phenolic acids, flavonoids or non-flavonoids. Research involving the synthesis of nanopolyphenols has attracted interest in the areas of functional food, nutraceutical and pharmaceutical development. This is in an effort to overcome current challenges which limit the application of polyphenols such as their rapid elimination, low water-solubility, instability at low pH, and their particle size. In the synthesis of nanopolyphenols, the type of nanocarrier used, the nanoencapsulation technique employed and the type of polymers that constitute the drug delivery system are crucial. For this review, all mentioned factors which can influence the therapeutic efficacy of nanopolyphenols were assessed. Their efficacy as anti-diabetic agents was also evaluated in 33 publications. Among these were phenolic acid (1), flavonoids (13), non-flavonoids (17) and polyphenolrich extracts (2). The most researched polyphenols were quercetin and curcumin. Nanoparticles were the main nanocarrier and the size of the nanopolyphenols ranged from 15 to 333 nm with encapsulation efficiency and drug loading capacities of 56-97.7% and 4.2-53.2%, respectively. The quantity of nanomaterial administered orally ranged from 1 to 300 mg/kg/day with study durations of 1-70 days. Most studies compared the effect of the nanopolyphenol to its freeform and, in all but three cases, significantly greater effects of the former were reported. Assessment of the polyphenol to understand its properties and the subsequent synthesis of its nanoencapsulated form using suitable nanocarriers, polymers and encapsulation techniques can result in effective therapeutic agents for the treatment of diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Diarylheptanoidmentioning

confidence: 99%

Section: Diarylheptanoidmentioning

confidence: 99%

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Nanopolyphenols: a review of their encapsulation and anti-diabetic effects

Rambaran

2020

SN Appl. Sci.

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“…Although nano-curcumin upregulated the Mn-SOD and downregulated the AGEPs gene expressions, AGE was more potent. 103 Nisin, an antimicrobial peptide, induced cell cycle arrest and apoptosis while reducing the head and neck squamous cell carcinoma cells. 104 A nanoformulation of nisin and curcumin was used to improve their delivery, stability, bioavailability, and pharmacological activity for CVDs treatment.…”

Section: Dovepressmentioning

confidence: 99%

“…Although nano-curcumin upregulated the Mn-SOD and downregulated the AGEPs gene expressions, AGE was more potent. 103 …”

Section: Natural Product-based Nanoformulations For Cardiovascular Diseasesmentioning

confidence: 99%

Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases

Hesari¹,

Mohammadi²,

Khademi³

et al. 2021

IJN

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Considering the high prevalence of cardiovascular diseases (CVDs), the primary cause of death during the last several decades, it is necessary to develop proper strategies for the prevention and treatment of CVDs. Given the excessive side effects of current therapies, alternative therapeutic approaches like medicinal plants and natural products are preferred. Lower toxicity, chemical diversity, cost-effectiveness, and proven therapeutic potentials make natural products superior compared to other products. Nanoformulation methods improve the solubility, bioavailability, circulation time, surface area-to-volume ratio, systemic adverse side effects, and drug delivery efficiency of these medications. This study intended to review the functionality of the most recent nanoformulated medicinal plants and/ or natural products against various cardiovascular conditions such as hypertension, atherosclerosis, thrombosis, and myocardial infarction. Literature review revealed that curcumin, quercetin, and resveratrol were the most applied natural products, respectively. Combination therapy, conjugation, or fabrication of nanoparticles and nanocarriers improved the applications and therapeutic efficacy of herbal-or natural-based nanoformulations. In the context of CVDs prevention and/or treatment, available data suggest that natural-based nanoformulations are considerably efficient, alone or in blend with other herbal/synthetic medicines. However, clinical trials are mandatory to elucidate the safety, cardioprotective effect, and mechanism of actions of nanophytomedicines.

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Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Liu

Zeng

et al. 2021

Advanced Science

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Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long‐term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia‐induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.

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The potential effect of garlic extract and curcumin nanoparticles against complication accompanied with experimentally induced diabetes in rats

Cited by 52 publications

References 56 publications

Nanopolyphenols: a review of their encapsulation and anti-diabetic effects

Nanopolyphenols: a review of their encapsulation and anti-diabetic effects

Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

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