2020
DOI: 10.1016/j.abb.2019.108205
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The potential effect of methylseleninic acid (MSA) against γ-irradiation induced testicular damage in rats: Impact on JAK/STAT pathway

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Cited by 18 publications
(7 citation statements)
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“…Radiation with single doses of > 1 Gy might initiate inflammatory reactions associated with oxidative stress and reduced antioxidant capacity [ 7 ]. Inflammatory signaling associated with IR might induce testicular damage [ 8 ]. Thus, controlling inflammation and oxidative damage is a primary strategy for ameliorating testicular injury after IR exposure.…”
Section: Introductionmentioning
confidence: 99%
“…Radiation with single doses of > 1 Gy might initiate inflammatory reactions associated with oxidative stress and reduced antioxidant capacity [ 7 ]. Inflammatory signaling associated with IR might induce testicular damage [ 8 ]. Thus, controlling inflammation and oxidative damage is a primary strategy for ameliorating testicular injury after IR exposure.…”
Section: Introductionmentioning
confidence: 99%
“…However, it has been shown that PPARGC1A and PRKAR1A are changed in spermatozoa of type 2 diabetes mellitus patients [ 55 ]. Furthermore, an increase in Nrf2 diminished testicular inflammation [ 56 ], while TFAM gene expression positively correlates with abnormal forms, sperm DNA fragmentation, and mtDNA copy number [ 29 , 30 ]. TFAM is essential for mammalian mtDNA transcription in animals and humans.…”
Section: Discussionmentioning
confidence: 99%
“…Our results showed a circadian-like type of transcriptional profile of Ppargc1a/ PGC1 in spermatozoa from both unstressed and stressed rats. It was published that PPARGC1A is changed in spermatozoa from patients suffering from type 2 diabetes mellitus ( 60 ) and that increased expression of Nrf2 diminished testicular inflammation ( 61 ). Also, our preliminary results show protein interaction of PGC1 and NRF1 proteins in spermatozoa (data not shown).…”
Section: Discussionmentioning
confidence: 99%