The Potential Effect of Silymarin Against Paracetamol-Induced Hepatotoxicity in Male Albino Rats

Abed, Noor Ahmed; Khalaf, Musab Mohammed; Alnori, Mohammed Khalid Jamaludeen

doi:10.5530/pj.2022.14.136

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…Oxidative stress occurs due to the disruption of the balance between oxidant agents and intracellular antioxidants (Kohnepoushi et al, 2020;Mohammadi et al, 2011;Omidifar et al, 2021). Herein, APAP significantly increased hepatic lipid peroxidation, which is in line with the findings of Al-Brakati et al (2019), Alvandi et al (2020) and Abed et al (2022). Moreover, APAP considerably reduced antioxidant reserves and thiol content in liver tissue.…”

Section: Discussionsupporting

confidence: 88%

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Therapeutic potentials of N‐acetylcysteine immobilized polyrhodanine nanoparticles toward acetaminophen‐induced acute hepatotoxicity in rat

Nili‐Ahmadabadi,

Abdpour,

Omidifar

et al. 2023

Chem Biol Drug Des

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N‐acetylcysteine (NAC) is a recommended drug for treating acetaminophen (APAP) intoxication. Due to NAC's low bioavailability, this study aimed to use polyrhodanine (PR) nanoparticles (NPs) as a drug carrier to improve the effectiveness of NAC. After preparation and characterization of NAC loaded on PR, 30 rats were randomly divided into five groups of six. The first group (control) received normal saline. Groups 2–5 were treated with normal saline, PR, NAC, and NAC loaded on PR, respectively. The treatments were started 4 h after oral administration of APAP (2000 mg kg−1). After 48 h, the animals were anesthetized, and liver function indices and oxidative stress were measured in tissue and serum samples. The APAP administration can increase aminotransferases and alkaline phosphatase enzymes in serum, decreasing the total antioxidant capacity and thiol groups and increasing lipid peroxidation in liver tissue. Administration of PR‐NAC could effectively improve the level of serum‐hepatic enzymes, total antioxidant capacity and thiol groups, lipid peroxidation, and pathological changes in liver tissue in animals poisoned with APAP. PR‐NAC has a significant therapeutic effect on preventing acute hepatotoxicity caused by APAP, and its effectiveness can be associated with an improvement in the oxidant/antioxidant balance of liver tissue.

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Section: Discussionsupporting

confidence: 88%

“…(2020) and Abed et al. (2022). Moreover, APAP considerably reduced antioxidant reserves and thiol content in liver tissue.…”

Section: Discussionmentioning

confidence: 94%

Therapeutic potentials of N‐acetylcysteine immobilized polyrhodanine nanoparticles toward acetaminophen‐induced acute hepatotoxicity in rat

Nili‐Ahmadabadi,

Abdpour,

Omidifar

et al. 2023

Chem Biol Drug Des

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The potential cardioprotective effect of Ganoderma lucidum against 5-fluorouracil cardiotoxicity

Ali,

Khalaf,

Ahmad

2024

Rev. Clin. Pharmacol. Pharmacokinet., Int. Ed.

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Background: 5-Fluorouracil (5-FU) is one of the commonly used anti-cancer drugs. However, it ranks as the second most common drug that causes cardiotoxicity. Ganoderma lucidum (G.L.) is a mushroom used for centuries for its different therapeutic properties. The aim of the study is to investigate the potential cardioprotective effect of G.L. against 5-FU cardiotoxicity, anti-inflammatory, and antioxidant properties. Material and methods: Thirty male Albino rats were divided into five groups. The control group was given normal saline orally for 14 days. The second group was treated as the control for 13 days and then 100 mg/kg 5-FU was administered intraperitoneally on day 14. The third group received G.L. 100 mg/kg orally for 13 days followed by a single 100 mg/kg 5-FU intraperitoneally on day 14. The fourth group was treated with 2 mg/kg enalapril orally for 13 days followed by a single 100 mg/kg 5-FU intraperi¬toneally on day 14. The last group received G.L. 100 mg/kg orally for 14 days. On day 15 the animals were eu¬thanized, and blood was collected for biochemical analysis of cardiac biomarkers (troponin (TNNI3) and heart-type fatty acid binding protein (H-FABP)), oxidative stress markers (total antioxidant capacity (TAC) and malondialdehyde (MDA)), and the pro-inflammatory marker (tumor necrosis factor-alpha (TNF-alpha)). The heart tissue was isolated for the histopathological investigation of cyclooxygenase-2 (COX-2) expression. Results: 5-FU administration has led to an increase in the level of H-FABP, TNNI3, MDA, TNF-alpha, and COX-2 expression while it has significantly reduced the level of TAC. G.L. could prevent the 5-FU-induced cardiotoxicity via its effect on all the measured parameters. Conclusion: G.L. can potentially offers cardioprotection against 5-FU-induced cardiotoxi¬city through its antioxidant and anti-inflammatory effects.

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The Potential Effect of Silymarin Against Paracetamol-Induced Hepatotoxicity in Male Albino Rats

Cited by 2 publications

References 32 publications

Therapeutic potentials of N‐acetylcysteine immobilized polyrhodanine nanoparticles toward acetaminophen‐induced acute hepatotoxicity in rat

Therapeutic potentials of N‐acetylcysteine immobilized polyrhodanine nanoparticles toward acetaminophen‐induced acute hepatotoxicity in rat

The potential cardioprotective effect of Ganoderma lucidum against 5-fluorouracil cardiotoxicity

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