The Potential Efficacy of Stevia Extract, Glimepiride and Their Combination in Treating Diabetic Rats: A Novel Strategy in Therapy of Type 2 Diabetes Mellitus

Assi, Abdel-Azim; El-hamid, Doaa H Abd; Abdelrahman, Mahmoud A. E.; Ashry, Esraa; Bayoumi, Soad A.H.; Ahmed, Abdel Ghaffar M.

doi:10.32527/2020/101455

Cited by 8 publications

(10 citation statements)

References 40 publications

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“…These results demonstrated that administration of stevia extract with dexamethasone caused a significant increase in liver GPx and a significant decrease in liver MDA compared to DEX treated group. These findings were in agreement with the results of previous studies 47,48 .…”

Section: Discussionsupporting

confidence: 94%

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The Potential Protective Effect of Stevia Rebaudiana on Dexamethasone-Induced Nonalcoholic Fatty Liver Disease in Rats: Role of Ppar-

Elbadr,

Mohamed,

Elsayed

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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Background: Currently, using medicinal herbs has a great interest in the treatment of nonalcoholic fatty liver disease (NAFLD). This study evaluated the impact of stevia on the hallmark signs of dexamethasone-induced NAFLD in rats. Methods: Group I: Negative control rats received 2 ml of vehicle carboxy methyl cellulose (CMC). Group II: Rats received dexamethasone 8 mg/kg/day intraperitoneal for 6 days. Group III: Rats received oral stevia extract 400 mg/kg/day for 12 days. Group IV: Rats received dexamethasone + stevia extract. Serum ALT, AST, TC, TG and adiponectin were measured. MDA, GPx and TNF-α were estimated in liver homogenate. Histopathological changes and PPAR-α expressions in the liver were evaluated. Results: Dexamethasone caused a reduction in GPx and ADP levels with an elevation in ALT, AST, TC, TG, MDA and TNF-α. There was a decrease in immunostaining expression of liver PPAR-α. Stevia caused an improvement in liver enzymes, lipid profile, oxidative stress, TNF-α and adiponectin levels. Conclusion: Stevia provided some protection against dexamethasone-induced NAFLD.

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Section: Discussionsupporting

confidence: 94%

“…The daily oral treatment of stevia extract (300 mg/kg) for 3 weeks significantly reversed TC and TG levels towards normal 47 . Stevia extract ameliorated liver dysfunction by controlling hyperglycemia, lowering elevated liver enzymes, providing an antioxidant effect and improving insulin resistance 48 .…”

Section: Discussionmentioning

confidence: 99%

The Potential Protective Effect of Stevia Rebaudiana on Dexamethasone-Induced Nonalcoholic Fatty Liver Disease in Rats: Role of Ppar-

Elbadr,

Mohamed,

Elsayed

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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“…The diabetic untreated rats in this study showed the main features of diabetic dyslipidemia: elevated triglycerides (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and a decrease in the high density lipoprotein-cholesterol (HDL-C). This observation is in consonance with the finding of Abdel-Azim Assi et al 31 . The observed elevated TG, TC and LDL could be partly due to increased intestinal biosynthesis of cholesterol because diabetes shifted the major site of cholesterogenesis from the liver to the small intestine leading to hypercholesterolemia 32 .…”

Section: Discussionsupporting

confidence: 93%

Comparative Effects of Cashew Nut, Leaf and Stem Bark (Anacardium Occidentale L.) on Hyperglycemia and Associated Abnormalities in Streptozotocin-Induced Diabetic Rats

Ajao

Akanmu

Iyedupe

2022

J. Drug Delivery Ther.

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Background: Medicinal plants are used as alternative therapy for diabetes. This study investigated comparative effects of methanolic extracts of Anacardium occidentale (linn) nut, leaf and stem bark on hyperglycemia and associated abnormalities in streptozotocin-induced diabetic rats. Methods: Ninety male Wistar albino rats weighing (200±20g) were used and diabetes was induced by single intraperitoneal injection of streptozotocin (50mg/kgb.wt). The rats were allotted into 9 groups, 10rats/group. Group I: (non-diabetic); Group II: (diabetic untreated); Groups: III & IV: diabetic rats received 100mg/kgb.wt& 200mg/kgb.wt nut extract; Groups: V & VI: diabetic rats received 100mg/kgb.wt& 200mg/kgb.wt leaves extract; VII & VIII were diabetic rats received 100mg/kgb.wt& 200mg/kgb.wt stem bark extract and Group IX: diabetic rats received 2mg/kgb.wt p.o glimepirides for 4weeks. Daily food and water intakes were recorded; weekly body weight and blood glucose levels were measured throughout the experiment. The animals were sacrificed on the last day and fasting plasma blood glucose was withdrawn for biochemical parameters estimation. Results: Fasting plasma blood glucose, triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), aspartate aminotransferase (AST), alanine aminotransferase, alkaline (ALT), aminotransferase (ALP), urea, uric acid, creatinine, malondialdehydes (MDA) and water intake levels were significantly (p<0.01, 0.05) reduced in the extracts treated groups. However, High density lipoprotein- cholesterol (HDL-C), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), body weight and food intake levels were significantly (p<0.01, 0.05) increased in the extracts treated groups. Conclusion: Anacardium occidentale parts posses anti-diabetic properties. The nut has extreme therapeutic efficacy and could be used as alternative therapy for diabetes. Keywords: Anacardium occidentale, Hyperglycemia, Lipid profiles, Antioxidants, Kidney function.

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“…22 These findings are consistent with our results but the difference lies in that we also recorded the effect of different forms of stevia. Another recent study in 2020 by Assi et al 23 obtained liver homogenate of diabetic rat models after treatment with stevia extract and found out that stevia ameliorated the raised MDA levels in diabetic murine model.…”

Section: Discussionmentioning

confidence: 99%

Comparative Effects of Whole Stevia Leaf and Rebaudioside A on Oxidative Stress in Male Obese Sprague Dawley Rats

Mubarak¹,

Faruqi²,

Riaz³

et al. 2023

PJMHS

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Background: Obesity is a dilemma nowadays for increasing percentage of people worldwide. Obesity induced oxidative stress due to increased tissue lipid levels, threatened redox state of cell and increased free radical formation leads to tissue oxidative stress. Fatty liver disease is a very common disorder related with obesity resulting in storage of fat goblets in the liver tissues leading to altered redox state called oxidative stress. Aim: To relate the outcome of Stevia and Rebaudioside A on Oxidative stress (MDA, SOD) in Obese Sprague Dawley Rats. Place and duration of study: Physiology Department of Islamabad Medical and Dental College, Islamabad, in collaboration with National Institute of Health (NIH) from 1st January 2020 to 30th June 2022. Methodology: One hundred and twenty healthy male Sprague Dawley rats were included. The animals were divided randomly into four groups of 30 rats each by simple randomization technique. Group 1 was given normal diet while the other three groups were given high fat diet. Stevia leaves and Rebaudioside A (rebiana) were further added for six weeks in the diet of Group 3 and 4 respectively. All animals were sacrificed at the end of study. Results: High fat diet induced oxidative stress in obese group was restored to approximate normal values of SOD (0.001) and MDA (0.001) by treatment with stevia and rebiana both (0.899). Conclusion: Stevia and Rebiana both cause improvement of oxidative stress unrewarding of expensive extraction procedures. Keywords: Stevia rebaudiana, Rebaudioside A, Sprague Dawley rats, Oxidative stress, NAFLD

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The Potential Efficacy of Stevia Extract, Glimepiride and Their Combination in Treating Diabetic Rats: A Novel Strategy in Therapy of Type 2 Diabetes Mellitus

Cited by 8 publications

References 40 publications

The Potential Protective Effect of Stevia Rebaudiana on Dexamethasone-Induced Nonalcoholic Fatty Liver Disease in Rats: Role of Ppar-

The Potential Protective Effect of Stevia Rebaudiana on Dexamethasone-Induced Nonalcoholic Fatty Liver Disease in Rats: Role of Ppar-

Comparative Effects of Cashew Nut, Leaf and Stem Bark (Anacardium Occidentale L.) on Hyperglycemia and Associated Abnormalities in Streptozotocin-Induced Diabetic Rats

Comparative Effects of Whole Stevia Leaf and Rebaudioside A on Oxidative Stress in Male Obese Sprague Dawley Rats

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