The contribution presents the impact of climate change on the hydropower potential in the Topľa River basin. There are various methodological approaches for determining the impact of climate change on the hydrological regime. One of them is the assessment of the impact of climate change on the hydropower potential. Changed climatic conditions, characterized mainly by changes in precipitation, potential evapotranspiration, and air temperature in future decades were predicted by recent outputs of the KNMI and MPI regional climate change models and the A1B emission scenario. To specify changes in long-term mean monthly runoff in comparison with the reference period 1981-2010 and future time horizons, the physically based WetSpa rainfall-runoff model was used. As a basic indicator of the potential for water energy utilization, hydropower potential (HPP) was calculated. An assessment of possible adaptation strategies for water management with respect to the hydropower potential and its utilization for energy production in Slovakia was attempted. The hydropower potential of small, run-of-river and storage hydropower plants is strongly related to the distribution of runoff over the year and can therefore affect not only the total change in runoff but also changes in its distribution in the future.