The potential for reducing alcohol consumption to prevent esophageal cancer morbidity in Asian heavy drinkers: a systematic review and meta-analysis

Kubo, Yuto; Kitagawa, Yuko; Miyazaki, Tatsuya; Sohda, Makoto; Yamaji, Taiki; Sakai, Makoto; Saeki, Hiroshi; Nemoto, Kenji; Oyama, Tsuneo; Muto, Manabu; Takeuchi, Hiroya; Toh, Yasushi; Matsubara, Hisahiro; Mano, Masayuki; Kono, Koji; Kato, Ken; Yoshida, Masahiro; Kawakubo, Hirofumi; Booka, Eisuke; Yamatsuji, Tomoki; Kato, Hiroyuki; Ito, Yoshiaki; Ishikawa, Hitoshi; Ishihara, Ryu; Tsushima, Takahiro; Kawachi, Hiroshi; Oyama, Takashi; Kojima, Takashi; Kuribayashi, Shiko; Makino, Tomoki; Matsuda, Satoru; Doki, Yuichiro

doi:10.1007/s10388-021-00892-4

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Epidemiological investigations have revealed that alcohol drinking is an autonomous risk factor for various types of malignancy. Kubo et al 31 reported that both heavy and light drinkers of alcohol had higher probabilities of developing EC, with the former being at a significantly greater risk. Park et al 32 discovered that continuous intake of alcohol beyond a low threshold was linked to an increased hazard of liver cancer, consistent with the findings of our MR analysis.…”

Section: Discussionmentioning

confidence: 99%

The effect of metabolism-related lifestyle and clinical risk factors on digestive system cancers in East Asian populations: a two-sample Mendelian randomization analysis

Cai,

Li,

Liang

et al. 2024

Sci Rep

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Metabolic factors play a critical role in the development of digestive system cancers (DSCs), and East Asia has the highest incidence of malignant tumors in the digestive system. We performed a two-sample Mendelian randomization analysis to explore the associations between 19 metabolism-related lifestyle and clinical risk factors and DSCs, including esophageal, gastric, colorectal, hepatocellular, biliary tract, and pancreatic cancer. The causal association was explored for all combinations of each risk factor and each DSC. We gathered information on the instrumental variables (IVs) from various sources and retrieved outcome information from Biobank Japan (BBJ). The data were all from studies of east Asian populations. Finally, 17,572 DSCs cases and 195,745 controls were included. Our analysis found that genetically predicted alcohol drinking was a strong indicator of gastric cancer (odds ratio (OR) = 0.95; 95% confidence interval (CI): 0.93–0.98) and hepatocellular carcinoma (OR = 1.11; 95% CI: 1.05–1.18), whereas coffee consumption had a potential protective effect on hepatocellular carcinoma (OR = 0.69; 95% CI: 0.53–0.90). Triglyceride was potentially associated with a decreased risk of biliary tract cancer (OR = 0.53; 95% CI: 0.34–0.81), and uric acid was associated with pancreatic cancer risk (OR = 0.59; 95% CI: 0.37–0.96). Metabolic syndrome (MetS) was associated with esophageal and gastric cancer. Additionally, there was no evidence for a causal association between other risk factors, including body mass index, waist circumference, waist-to-hip ratio, educational levels, lipoprotein cholesterol, total cholesterol, glycine, creatinine, gout, and Graves’ disease, and DSCs. The leave-one-out analysis revealed that the single nucleotide polymorphism (SNP) rs671 from the ALDH2 gene has a disproportionately high contribution to the causal association between alcohol drinking and gastric cancer and hepatocellular carcinoma, as well as the association between coffee consumption and hepatocellular carcinoma. The present study revealed multiple metabolism-related lifestyle and clinical risk factors and a valuable SNP rs671 for DSCs, highlighting the significance of metabolic factors in both the prevention and treatment of DSCs.

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Section: Discussionmentioning

confidence: 99%

The effect of metabolism-related lifestyle and clinical risk factors on digestive system cancers in East Asian populations: a two-sample Mendelian randomization analysis

Cai,

Li,

Liang

et al. 2024

Sci Rep

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“…Alcohol consumption is a strong risk factor for esophageal squamous cell carcinoma, but is not a risk factor for adenocarcinoma [3]. Overweight and obesity have been consistently related to esophageal adenocarcinoma, but not to squamous cell carcinoma.…”

Section: Risk Factor In Carcinoma Esophagus In Punjab Region Of North...mentioning

confidence: 95%

“…Divya Mahajan 1 , Nikhil Makkar 2 , Raja Paramjeet Singh Banipal 3 Squamous cell carcinoma occur due to inflammatory changes that progresses to dysplasia and in situ malignant change. Tobacco smoking is a strong risk factor for esophageal squamous cell carcinoma, but weak risk factor for esophageal adenocarcinoma [4].…”

Section: Risk Factor In Carcinoma Esophagus In Punjab Region Of North...mentioning

confidence: 99%

“…Risk factors involved in carcinoma esophagus are tobacco consumption, unhealthy diet like spicy food, alcohol [3], tobacco [4] and diet deficient in trace elements mostly selenium, alkalinity of soil, genetic variation and low socio-economic status [4]. Squamous cell carcinoma is predominantly seen in upper two thirds of esophagus unlike Adenocarcinoma, which is seen in lower one third.…”

Section: Introductionmentioning

confidence: 99%

“…Government Medical College and Hospital Chandigarh, India. 2 IVY Hospital Mohali Punjab, Deparment of Plastic Surgery, India 3. Goverment Medical College Patiala Head of Department of Radiation Oncology, India.…”

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confidence: 99%

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Risk Factor in Carcinoma Esophagus in Punjab Region of North India

Mahajan,

Makkar,

Singh Banipal

2023

Asian Pac J Cancer Biol

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Background: World over, esophageal cancer is the seventh most common cancer. It accounts for sixth most common deaths related to cancer. Studies have included various risk factors such as tobacco consumption, unhealthy diet like spicy food, alcohol, and diet deficient in trace elements mostly selenium, alkalinity of soil, genetic variation and low socio-economic status, have been implicated in the etiology of esophageal cancer.Method: A descriptive observational study of carcinoma esophagus patients between May, 2019 to October, 2020 was performed. A total of first consecutive 70 patients meeting the eligibility criteria were considered for study. Data was collected by personal interview.Results: Data was collected by personal interview. 82.9% of population resided in rural areas. 100% of patients consumed hot beverages with 70% of patients consumed tea, 11.4% consumed coffee and 18.6% consumed both. 60% of patient population used wood for cooking, 22.9% used liquefied petroleum gas (LPG), and 17.1% used cow dung. 25.7% of population consumed cigarette/Bidi, 10% consumed hookah, 7.1% consumed jarda and 28.6% consumed alcohol. 42.9% of patients had pesticide exposure. 47.6% of squamous cell type had pesticide exposure which was statistically significant. Conclusion: General public should also be made aware of the harmful effects of consuming spicy, high salt diet and hot beverages along with cigarette smoking and alcohol.

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Identification of tissue-specific microbial profile of esophageal squamous cell carcinoma by full-length 16S rDNA sequencing

Shen

Tang

Wan

et al. 2022

Appl Microbiol Biotechnol

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The potential for reducing alcohol consumption to prevent esophageal cancer morbidity in Asian heavy drinkers: a systematic review and meta-analysis

Cited by 7 publications

References 29 publications

The effect of metabolism-related lifestyle and clinical risk factors on digestive system cancers in East Asian populations: a two-sample Mendelian randomization analysis

The effect of metabolism-related lifestyle and clinical risk factors on digestive system cancers in East Asian populations: a two-sample Mendelian randomization analysis

Risk Factor in Carcinoma Esophagus in Punjab Region of North India

Identification of tissue-specific microbial profile of esophageal squamous cell carcinoma by full-length 16S rDNA sequencing

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