The Potential Impact of Bone Tissue Engineering in the Clinic

Mishra, Ruchi; Bishop, Tyler J; Valerio, Ian L.; Fisher, John P.; Dean, David

doi:10.2217/rme-2016-0042

Cited by 64 publications

(51 citation statements)

References 97 publications

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“…However, these methods have different drawbacks such as high morbidity, pain, potential infection and tissue rejection, which can lead to long term health complications [3] . Bone tissue engineering (TE) represents an alternative to treat these problems by using combination of biomaterials, biomolecules and cells to grow new tissue with the same properties and functionality of the damaged host [3] , [4] . A variety of natural and synthetic materials has been investigated over the last decades for bone tissue engineering including combination of various biomaterials and designs [4] .…”

Section: Introductionmentioning

confidence: 99%

Bioactivation of titanium dioxide scaffolds by ALP-functionalization

Sengottuvelan

Balasubramanian

Will

et al. 2017

Bioactive Materials

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Three dimensional TiO2 scaffolds are receiving renewed attention for bone tissue engineering (TE) due to their biocompatibility and attractive mechanical properties. However the bioactivity of these scaffolds is comparatively lower than that of bioactive glass or hydroxyapatite (HA) scaffolds. One strategy to improve bioactivity is to functionalize the surface of the scaffolds using biomolecules. Alkaline phosphatase (ALP) was chosen in this study due to its important role in the bone mineralization process. The current study investigated the ALP functionalization of 3D titanium dioxide scaffolds using self-polymerization of dopamine. Robust titanium scaffolds (compressive strength∼2.7 ± 0.3 MPa) were produced via foam replica method. Enzyme grafting was performed by dip-coating in polydopamine/ALP solution. The presence of ALP was indirectly confirmed by contact angle measurements and enzymatic activity study. The influence of the enzyme on the bioactivity, e.g. hydroxyapatite formation on the scaffold surface, was measured in simulated body fluid (SBF). After 28 days in SBF, 5 mg ALP coated titania scaffolds exhibited increased hydroxyapatite formation. It was thus confirmed that ALP enhances the bioactivity of titania scaffolds, converting an inert bioceramic in an attractive bioactive system for bone TE.

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Section: Introductionmentioning

confidence: 99%

Bioactivation of titanium dioxide scaffolds by ALP-functionalization

Sengottuvelan

Balasubramanian

Will

et al. 2017

Bioactive Materials

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“…Cell-based strategies for bone tissue engineering have a long trajectory in the research stage but have minimally contributed to current clinical practices ( Mishra et al, 2016 ). Indeed, the introduction of cells as a component in tissue engineering entails important economic and safety concerns; the former is related to the logistics, technology and human resources necessary and the latter is related to possible immunogenicity, teratoma formation and disease transmission risks ( Webber et al, 2015 ).…”

Section: Biomaterials and Stem Cells Combining Technologiesmentioning

confidence: 99%

The Few Who Made It: Commercially and Clinically Successful Innovative Bone Grafts

Sallent

Capella-Monsonís

Procter

et al. 2020

Front. Bioeng. Biotechnol.

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Bone reconstruction techniques are mainly based on the use of tissue grafts and artificial scaffolds. The former presents well-known limitations, such as restricted graft availability and donor site morbidity, while the latter commonly results in poor graft integration and fixation in the bone, which leads to the unbalanced distribution of loads, impaired bone formation, increased pain perception, and risk of fracture, ultimately leading to recurrent surgeries. In the past decade, research efforts have been focused on the development of innovative bone substitutes that not only provide immediate mechanical support, but also ensure appropriate graft anchoring by, for example, promoting de novo bone tissue formation. From the countless studies that aimed in this direction, only few have made the big jump from the benchtop to the bedside, whilst most have perished along the challenging path of clinical translation. Herein, we describe some clinically successful cases of bone device development, including biological glues, stem cell-seeded scaffolds, and gene-functionalized bone substitutes. We also discuss the ventures that these technologies went through, the hindrances they faced and the common grounds among them, which might have been key for their success. The ultimate objective of this perspective article is to highlight the important aspects of the clinical translation of an innovative idea in the field of bone grafting, with the aim of commercially and clinically informing new research approaches in the sector.

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“…Although autografts are considered the gold standard for promoting bone repair [7][8][9], they present several limitations, including risks of donor site injury, morbidity, and limited availability [10,11]. Bone tissue engineering is therefore seeking more efficient strategies to further regenerate viable bone tissue through a combination of cells, biomaterials, bone active proteins, and drugs [12][13][14]. However, it is important that biomaterials can provide a balanced ability to mechanically support initial scaffolding in the defect site, while encouraging cells to migrate onto and commence the bone healing process.…”

Section: Introductionmentioning

confidence: 99%

Exploratory Full-Field Strain Analysis of Regenerated Bone Tissue from Osteoinductive Biomaterials

et al. 2020

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Biomaterials for bone regeneration are constantly under development, and their application in critical-sized defects represents a promising alternative to bone grafting techniques. However, the ability of all these materials to produce bone mechanically comparable with the native tissue remains unclear. This study aims to explore the full-field strain evolution in newly formed bone tissue produced in vivo by different osteoinductive strategies, including delivery systems for BMP-2 release. In situ high-resolution X-ray micro-computed tomography (microCT) and digital volume correlation (DVC) were used to qualitatively assess the micromechanics of regenerated bone tissue. Local strain in the tissue was evaluated in relation to the different bone morphometry and mineralization for specimens (n = 2 p/treatment) retrieved at a single time point (10 weeks in vivo). Results indicated a variety of load-transfer ability for the different treatments, highlighting the mechanical adaptation of bone structure in the early stages of bone healing. Although exploratory due to the limited sample size, the findings and analysis reported herein suggest how the combination of microCT and DVC can provide enhanced understanding of the micromechanics of newly formed bone produced in vivo, with the potential to inform further development of novel bone regeneration approaches.

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The Potential Impact of Bone Tissue Engineering in the Clinic

Cited by 64 publications

References 97 publications

Bioactivation of titanium dioxide scaffolds by ALP-functionalization

Bioactivation of titanium dioxide scaffolds by ALP-functionalization

The Few Who Made It: Commercially and Clinically Successful Innovative Bone Grafts

Exploratory Full-Field Strain Analysis of Regenerated Bone Tissue from Osteoinductive Biomaterials

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