The potential impact of COVID-19 and diabetes on intervertebral disc degeneration

Lopes, Luciano Rodrigo; Kasinski, Silvana Kertzer

doi:10.31744/einstein_journal/2021ce6911

Cited by 1 publication

(2 citation statements)

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“…Previous study has speculated that SARS-CoV-2 promotes an in ammatory response and oxidative stress, which can cause the intervertebral disc to enter a catabolic state that drives intervertebral disc degeneration [11]. However, the underlying mechanisms remain incompletely elucidated.…”

Section: Discussionmentioning

confidence: 99%

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RRM2: a crosstalk gene for COVID-19 and intervertebral disc degeneration revealed by integrated WGCNA and machine learning

Cai,

Liu,

Yang

et al. 2024

Preprint

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Background: Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP), and COVID-19 has been reported to be an important risk factor for IDD. The aim of this study was to explore the molecular mechanisms underlying the effects of COVID-19 on IDD by identifying overlapping crosstalk genes associated with these two conditions. The identification of crosstalk genes between COVID-19 and IDD patients will have important clinical implications for early intervention in COVID-19 secondary IDD. Methods: The gene expression profiles of GSE157103 and GSE70362 were extracted from the GEO database. These profiles were then subjected to analysis using WGCNA, Lasso, and SVM-RFE, resulting in the identification of RRM2 as a crosstalk gene for both COVID-19 and IDD. Additionally, GSEA was employed to investigate the potential mechanisms by which RRM2 exerts its effects in disease. Furthermore, a relationship between RRM2 and immune cells was revealed through correlation analysis. Finally, independent external datasets (GSE171110 and GSE146904) were utilized to validate the diagnostic efficacy of RRM2. Results: The crosstalk gene RRM2 for both COVID-19 and IDD was identified through the application of WGCNA and machine learning algorithm. GSEA analysis further revealed that RRM2 participates in fatty acid metabolism, thereby promoting disc degeneration in IDD. Moreover, immunocorrelation analyses unveiled a negative regulatory role of RRM2 in CD56-bright natural killer cells and its induction of IDD disc degeneration. Conclusions: A crosstalk gene of COVID-19 and IDD, RRM2, was identified using WGCNA and machine learning algorithm, providing a new perspective for exploring possible mechanisms of secondary IDD in COVID-19.

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Section: Discussionmentioning

confidence: 99%

“…However, certain pathophysiological effects have been reported which may cause IDD during the clinical course of severe COVID-19. COVID-19 has been suggested as a signi cant factor in IDD [11]. SARS-CoV-2 is thought to bind to the angiotensin-converting enzyme 2 (ACE2) receptor found in human nucleus pulposus (NP) cells.…”

Section: Introductionmentioning

confidence: 99%