The potential impact of nanomedicine on COVID-19-induced thrombosis

Russell, Peije; Esser, Lars; Hagemeyer, Christoph E.; Voelcker, Nicolas H.

doi:10.1038/s41565-022-01270-6

Cited by 8 publications

(6 citation statements)

References 121 publications

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“…Therefore, researchers have studied the use of antibodies based on their favourable high affinity. In this regard, an earlier study reported increased accumulation of perfluorocarbon nanoparticle combined with anti-fibrin monoclonal antibody, at the thrombus[ 33 ].…”

Section: Nanomedicines and Nano Immunotherapeutic For Respiratory Dis...mentioning

confidence: 99%

“…Comparatively, glycyrrhizic acid nanoparticles showed limited efficacy, however, both polylysineand silver nanoparticles showed a positive correlation between their surface charge and antiviral activity. For optimal inhibition of the virus, silver nanoparticles showed size-dependent virucidal properties with 10 nm nanoparticles, while 100 nm nanoparticles were entirely ineffective[ 33 , 37 ]. Several groups that can utilize ACE2-expressing membranes to develop nanoconstructscan competitively bind and trap SARS-CoV-2.…”

Section: Immunosuppressant and Antiviral Based Nanomedicinesmentioning

confidence: 99%

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Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis

Wu,

Zheng,

Zhang

et al. 2024

World J Clin Cases

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Immunotherapy and associated immune regulation strategies gained huge attraction in order to be utilized for treatment and prevention of respiratory diseases. Engineering specifically nanomedicines can be used to regulate host immunity in lungs in the case of respiratory diseases including coronavirus disease 2019 (COVID-19) infection. COVID-19 causes pulmonary embolisms, thus new therapeutic options are required to target thrombosis, as conventional treatment options are either not effective due to the complexity of the immune-thrombosis pathophysiology. In this review, we discuss regulation of immune response in respiratory diseases especially COVID-19. We further discuss thrombosis and provide an overview of some antithrombotic nanoparticles, which can be used to develop nanomedicine against thrombo-inflammation induced by COVID-19 and other respiratory infectious diseases. We also elaborate the importance of immunomodulatory nanomedicines that can block pro-inflammatory signalling pathways, and thus can be recommended to treat respiratory infectious diseases.

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Section: Nanomedicines and Nano Immunotherapeutic For Respiratory Dis...mentioning

confidence: 99%

Section: Immunosuppressant and Antiviral Based Nanomedicinesmentioning

confidence: 99%

Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis

Wu,

Zheng,

Zhang

et al. 2024

World J Clin Cases

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Section: Introductionmentioning

confidence: 99%

“…Over the past two decades, numerous types of nanoparticles have been explored for a variety of biomedical applications ranging from drug delivery to cancer therapy, biomedical imaging, nano-vaccine, and disease diagnosis, among others. [1][2][3][4] For most of these applications, the nanoparticlecell interaction is the primary consideration during the design of the nanoparticles. Especially, the nanoparticle-cell membrane interaction and the subsequent cellular internalization rate and efficiency play a critical role in determining the performance of the nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization

Xia,

Zhou,

et al. 2024

Angew Chem Int Ed

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Controlling the nanoparticle‐cell membrane interaction to achieve easy and fast membrane anchoring and cellular internalization is of great importance in a variety of biomedical applications. Here we report a simple and versatile strategy to maneuver the nanoparticle‐cell membrane interaction by creating a tunable hydrophobic protrusion on Janus particles through swelling‐induced symmetry breaking. When the Janus particle contacts cell membrane, the protrusion will induce membrane wrapping, leading the particles to docking to the membrane, followed by drawing the whole particles into the cell. The efficiencies of both membrane anchoring and cellular internalization can be promoted by optimizing the size of the protrusion. In vitro, the Janus particles can quickly anchor to the cell membrane in 1 h and be internalized within 24 h, regardless of the types of cells involved. In vivo, the Janus particles can effectively anchor to the brain and skin tissues to provide a high retention in these tissues after intracerebroventricular, intrahippocampal, or subcutaneous injection. This strategy involving the creation of a hydrophobic protrusion on Janus particles to tune the cell‐membrane interaction holds great potential in nanoparticle‐based biomedical applications.

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“…Nanomaterials, which are approximately 1–100 nm in size, have many advantages, such as the targeting ability, good biocompatibility, stability, and extremely low toxicity ( Riehemann et al, 2009 ). Many studies have proven that nanomaterials, as therapeutic agents or drug delivery carriers, have great applications in the medical field, to treat conditions such as inflammatory diseases, infectious diseases, cardiovascular diseases, and cancer ( Kim et al, 2010 ; Psarros et al, 2012 ; Liu et al, 2018 ; Liu et al, 2019 ; Liu et al, 2020 ; Liu et al, 2021a ; Liu et al, 2021b ; Moses et al, 2021 ; Wang et al, 2022 ; Zhang et al, 2022 ; Xu et al, 2023a ; You et al, 2023 ; Russell et al, 2023 ). To date, nanotechnology-based approaches have been valid in non-invasive diagnosis and treatment of endometriosis, which effectively target ectopic tissues and cells without causing systemic effects.…”

Section: Introductionmentioning

confidence: 99%

Applications of nanomaterials in endometriosis treatment

Yuxue,

Ran,

Minghui

et al. 2023

Front. Bioeng. Biotechnol.

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Endometriosis is a common disease of the reproductive system in women of childbearing age with an unclear pathogenesis. Endometriosis mainly manifests as dysmenorrhea, abdominal pain, and infertility. Currently, medical therapy and surgical treatment are usually used for endometriosis treatment. However, due to the high recurrence rate and many complications, it has greatly affected patients’ quality of life. Nanotechnology is a new technology that mainly investigates the characteristics and applications of nanomaterials. To date, nanotechnology has received widespread attention in the field of biomedicine. Nanomaterials can not only be used as drugs to treat endometriosis directly, but also enhance the therapeutic effect of endometriosis by delivering drugs, siRNA, antibodies, vesicles, etc. This review comprehensively discusses nanomaterial-based therapies for endometriosis treatment, such as nanomaterial-based gene therapy, photothermal therapy, immunotherapy, and magnetic hyperthermia, which provides a theoretical reference for the clinical application of nanotechnology in the treatment of endometriosis.

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The potential impact of nanomedicine on COVID-19-induced thrombosis

Cited by 8 publications

References 121 publications

Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis

Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis

Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization

Applications of nanomaterials in endometriosis treatment

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