The potential involvement of glycocalyx disruption in abdominal aortic aneurysm pathogenesis

Rabia, Bibi; Thanigaimani, Shivshankar; Golledge, Jonathan

doi:10.1016/j.carpath.2024.107629

Cited by 1 publication

(1 citation statement)

References 106 publications

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“…The shedding of glycosaminoglycans from EGC facilitates the release of chemokines and proinflammatory cytokines embedded in the EGC into the circulation [66][67][68]. In turn, the proinflammatory cytokines further promote glycocalyx shedding [58,69,70].…”

Section: Emerging Insights Into the Endothelial Glycocalyx During Hea...mentioning

confidence: 99%

Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery

Kršek,

Batičić,

Ćurko-Cofek

et al. 2024

CIMB

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The endothelial glycocalyx (EGC) is a layer of proteoglycans (associated with glycosaminoglycans) and glycoproteins, which adsorbs plasma proteins on the luminal surface of endothelial cells. Its main function is to participate in separating the circulating blood from the inner layers of the vessels and the surrounding tissues. Physiologically, the EGC stimulates mechanotransduction, the endothelial charge, thrombocyte adhesion, leukocyte tissue recruitment, and molecule extravasation. Hence, severe impairment of the EGC has been implicated in various pathological conditions, including sepsis, diabetes, chronic kidney disease, inflammatory disorders, hypernatremia, hypervolemia, atherosclerosis, and ischemia/reperfusion injury. Moreover, alterations in EGC have been associated with altered responses to therapeutic interventions in conditions such as cardiovascular diseases. Investigation into the function of the glycocalyx has expanded knowledge about vascular disorders and indicated the need to consider new approaches in the treatment of severe endothelial dysfunction. This review aims to present the current understanding of the molecular mechanisms underlying cardiovascular diseases and to elucidate the impact of heart surgery on EGC dysfunction.

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Section: Emerging Insights Into the Endothelial Glycocalyx During Hea...mentioning

confidence: 99%

Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery

Kršek,

Batičić,

Ćurko-Cofek

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

The potential involvement of glycocalyx disruption in abdominal aortic aneurysm pathogenesis

Cited by 1 publication

References 106 publications

Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery

Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery

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